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Investigating the modulation of the endocannabinoid system by probiotic Lactiplantibacillus plantarum IMC513 in a zebrafish model of di-n-hexyl phthalate exposure
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Researchers found that a probiotic strain (Lactiplantibacillus plantarum IMC513) protected zebrafish from neurological disruption caused by di-n-hexyl phthalate, a plasticizer chemical used in food packaging, by restoring normal gene expression in the brain's endocannabinoid signaling system. This suggests probiotics may help counteract the brain and gut effects of phthalate exposure from plastic products.
Environmental pollutants used as plasticizers in food packaging and in thousands of everyday products have become harmful for their impact on human health. Among them, phthalates, recognized as emerging endocrine disruptors (EDs) can induce toxic effects leading to different health disorders. Only few studies evaluated the effects of di-n-hexyl phthalate (DnHP) in in vivo models and no studies have been conducted to investigate the effect of DnHP on the endocannabinoid system (ECS), one of the majors signaling pathways involved in the microbiota-gut-brain axis. Due to the current relevance of probiotic bacteria as beneficial dietary interventions, the present study was aimed at evaluating the potential neuroprotective impact of daily administration of Lactiplantibacillus (Lpb.) plantarum IMC513 on zebrafish adults exposed to DnHP, with a focus on ECS modulation. Gene expression analysis revealed a promising protective role of probiotic through the restoration of ECS genes expression to the control level, in the brain of zebrafish daily exposed to DnHP. In addition, the levels of main endocannabinoids were also modulated. These findings confirm the potential ability of probiotics to interact at central level by modulating the ECS, suggesting the use of probiotics as innovative dietary strategy to counteract alterations by EDs exposure.
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Researchers tested whether the probiotic supplement SLAB51 could counteract the harmful effects of bisphenol A (BPA), a plastic-derived chemical, in zebrafish and found it significantly restored healthy gut bacteria, reduced liver damage, and protected the brain — suggesting probiotics may help offset harm from plastic-associated chemical exposure.
Lactiplantibacillus plantarum P101 Alleviates Liver Toxicity of Combined Microplastics and Di-(2-Ethylhexyl) Phthalate via Regulating Gut Microbiota
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Researchers found that the probiotic Lactiplantibacillus plantarum P101 reduced liver damage caused by combined exposure to microplastics and the plasticizer DEHP in mice. The probiotic reversed oxidative stress and inflammation in the liver and intestines while reshaping the gut microbiota. The study suggests that probiotic supplementation may offer a promising strategy for mitigating the toxic effects of co-exposure to microplastics and plastic-associated chemicals.
Lactiplantibacillus plantarum PD01 supplementation reduces microplastics and microplastic-associated chemicals in humans: A randomized, double-blind, placebo-controlled trial
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In a randomized, double-blind, placebo-controlled trial, 106 participants took Lactiplantibacillus plantarum PD01 or a placebo three times a day. Urinary phthalate metabolites were the first measure analyzed, and they fell by roughly 35 to 60% after six weeks in the probiotic group.
Lactiplantibacillus plantarum F57 mitigates waterborne polypropylene microplastic-induced liver injury via gut microbiota modulation in zebrafish
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Zebrafish exposed to 50 micrometer polypropylene microplastics in water developed liver inflammation and oxidative stress. Among the Lactiplantibacillus plantarum strains tested, F57 was associated with the least liver injury and with a more diverse gut microbiota. Antioxidant capacity tracked with the result more closely than the strains' ability to bind the particles.
Damage of polyethylene microplastics on the intestine multilayer barrier, blood cell immune function and the repair effect of Leuconostoc mesenteroides DH in the large-scale loach (Paramisgurnus dabryanus)
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Researchers found that polyethylene microplastics damage the intestinal lining of loach fish, allowing plastic particles to break through the gut barrier and enter the bloodstream, where they caused blood cell death. Adding a probiotic bacterium (Leuconostoc mesenteroides) to the fish's diet significantly repaired the intestinal damage and improved immune function. This suggests that probiotics may help counteract some of the gut damage caused by microplastic exposure.
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