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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Gut & Microbiome Human Health Effects Marine & Wildlife Nanoplastics Sign in to save

Vitamin D modulation of brain-gut-virome disorder caused by polystyrene nanoplastics exposure in zebrafish (Danio rerio)

Microbiome 2023 35 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 60 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Miaomiao Teng, Xiaoli Zhao, Miaomiao Teng, Miaomiao Teng, Xiaoli Zhao, Xiaoli Zhao, Yunxia Li, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Miaomiao Teng, Xiaoli Zhao, Miaomiao Teng, Jiaqi Sun, Xiaoli Zhao, Jiaqi Sun, Xiaoli Zhao, Miaomiao Teng, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Jiaqi Sun, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Yunxia Li, Yunxia Li, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Jason C. White Miaomiao Teng, Lihui Zhao, Lihui Zhao, Lihui Zhao, Lihui Zhao, Lihui Zhao, Lihui Zhao, Lihui Zhao, Miaomiao Teng, Fengchang Wu, Lihui Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Fengchang Wu, Xiaoli Zhao, Wentao Zhu, Wentao Zhu, Wentao Zhu, Jason C. White Xiaoli Zhao, Fengchang Wu, Xiaoli Zhao, Xiaoli Zhao, Miaomiao Teng, Xiaoli Zhao, Jason C. White Jason C. White Fengchang Wu, Miaomiao Teng, Jason C. White Fengchang Wu, Fengchang Wu, Fengchang Wu, Xiaoli Zhao, Jason C. White Xiaoli Zhao, Xiaoli Zhao, Jason C. White Jason C. White Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Fengchang Wu, Fengchang Wu, Fengchang Wu, Jason C. White Jason C. White Jason C. White Jason C. White Jason C. White Jason C. White Jason C. White Miaomiao Teng, Wentao Zhu, Lihui Zhao, Lihui Zhao, Lihui Zhao, Lihui Zhao, Lihui Zhao, Yunxia Li, Miaomiao Teng, Miaomiao Teng, Lihui Zhao, Fengchang Wu, Jiaqi Sun, Jason C. White Wentao Zhu, Fengchang Wu, Fengchang Wu, Jiaqi Sun, Xiaoli Zhao, Fengchang Wu, Jason C. White Fengchang Wu, Xiaoli Zhao, Fengchang Wu, Xiaoli Zhao, Fengchang Wu, Xiaoli Zhao, Fengchang Wu, Jason C. White Jason C. White Jason C. White Xiaoli Zhao, Miaomiao Teng, Wentao Zhu, Wentao Zhu, Fengchang Wu, Miaomiao Teng, Yunxia Li, Xiaoli Zhao, Xiaoli Zhao, Fengchang Wu, Fengchang Wu, Jason C. White Xiaoli Zhao, Miaomiao Teng, Wentao Zhu, Miaomiao Teng, Miaomiao Teng, Xiaoli Zhao, Fengchang Wu, Miaomiao Teng, Fengchang Wu, Fengchang Wu, Fengchang Wu, Wentao Zhu, Xiaoli Zhao, Jason C. White Fengchang Wu, Fengchang Wu, Jason C. White Jason C. White Jason C. White Jason C. White Wentao Zhu, Fengchang Wu, Wentao Zhu, Jason C. White Jason C. White Jason C. White Xiaoli Zhao, Jason C. White Jason C. White Fengchang Wu, Fengchang Wu, Fengchang Wu, Xiaoli Zhao, Fengchang Wu, Fengchang Wu, Jason C. White Jason C. White

Summary

In zebrafish exposed to polystyrene nanoplastics, a vitamin D-rich diet reduced nanoplastic accumulation in the brain by 20% and in the intestine by over 50%, while also reducing anxiety-like behavior. The nanoplastics disrupted the gut-brain connection by altering intestinal viruses, but vitamin D helped counteract these effects. This study suggests that adequate vitamin D intake might help protect against some of the harmful effects of nanoplastic exposure on the brain and gut.

Polymers
PS
Body Systems
Immune Nervous
Models
Zebrafish

BACKGROUND: Many studies have investigated how nanoplastics (NPs) exposure mediates nerve and intestinal toxicity through a dysregulated brain-gut axis interaction, but there are few studies aimed at alleviating those effects. To determine whether and how vitamin D can impact that toxicity, fish were supplemented with a vitamin D-low diet and vitamin D-high diet. RESULTS: Transmission electron microscopy (TEM) showed that polystyrene nanoplastics (PS-NPs) accumulated in zebrafish brain and intestine, resulting in brain blood-brain barrier basement membrane damage and the vacuolization of intestinal goblet cells and mitochondria. A high concentration of vitamin D reduced the accumulation of PS-NPs in zebrafish brain tissues by 20% and intestinal tissues by 58.8% and 52.2%, respectively, and alleviated the pathological damage induced by PS-NPs. Adequate vitamin D significantly increased the content of serotonin (5-HT) and reduced the anxiety-like behavior of zebrafish caused by PS-NPs exposure. Virus metagenome showed that PS-NPs exposure affected the composition and abundance of zebrafish intestinal viruses. Differentially expressed viruses in the vitamin D-low and vitamin D-high group affected the secretion of brain neurotransmitters in zebrafish. Virus AF191073 was negatively correlated with neurotransmitter 5-HT, whereas KT319643 was positively correlated with malondialdehyde (MDA) content and the expression of cytochrome 1a1 (cyp1a1) and cytochrome 1b1 (cyp1b1) in the intestine. This suggests that AF191073 and KT319643 may be key viruses that mediate the vitamin D reduction in neurotoxicity and immunotoxicity induced by PS-NPs. CONCLUSION: Vitamin D can alleviate neurotoxicity and immunotoxicity induced by PS-NPs exposure by directionally altering the gut virome. These findings highlight the potential of vitamin D to alleviate the brain-gut-virome disorder caused by PS-NPs exposure and suggest potential therapeutic strategies to reduce the risk of NPs toxicity in aquaculture, that is, adding adequate vitamin D to diet. Video Abstract.

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