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Papers
61,005 resultsShowing papers similar to IL-11-Engineered Macrophage Membrane-Coated Reactive Oxygen Species-Responsive Nanoparticles for Targeted Delivery of Doxorubicin to Osteosarcoma
ClearBiomembrane-wrapped gene delivery nanoparticles for cancer therapy
This review examined biomembrane-wrapped nanoparticles as gene delivery vehicles for cancer therapy, highlighting how cell membrane coatings improve targeting, immune evasion, and therapeutic efficacy compared to conventional synthetic delivery systems.
Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment
This review covers advances in targeted drug delivery using nanotechnology, including nanoparticles and liposomes designed to release medications precisely where needed in the body. While focused on cancer treatment, the drug delivery technologies discussed are relevant to understanding how nanoscale plastic particles may also travel through the body and accumulate in specific tissues.
Unraveling the impact of nanoplastics on bone microenvironment: focus on extracellular vesicle-mediated communication and oxidative stress in multiple myeloma.
This study reviewed how nanoplastic particles disrupt the bone microenvironment through oxidative stress and damage to the extracellular matrix. Reactive oxygen species generated by nanoplastic exposure were found to drive toxicity in bone cells.
Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis
This systematic review found a strong trend toward using graphene oxide-based nanomaterials for treating osteosarcoma (bone cancer), leveraging their thermal and anti-cancer properties. Photodynamic therapy, photothermal therapy, and nanocarrier delivery systems using GO showed promise as non-invasive, targeted alternatives to conventional bone cancer treatments.
Novel application of microparticles demonstrate myeloid uptake and induce phenotypic change within the brain tumor microenvironment 2254
Researchers demonstrated that microparticles can be taken up by myeloid cells within glioblastoma tumors and can induce phenotypic changes in tumor-associated macrophages and neutrophils, suggesting that particle-based approaches may be able to modify the immunosuppressive tumor microenvironment.
Nanoparticles in Drug Delivery
This review examines how nanoparticles made from various materials, including polymers, are being developed for targeted drug delivery across biological barriers. Researchers highlighted advances in stimuli-responsive nanoparticle engineering for tumor targeting and the integration of AI models for personalized medicine. While focused on biomedical applications, the study is relevant to understanding how polymer-based particles interact with biological systems at the nanoscale.
Reversing the immunosuppressive microenvironment with reduced redox level by microwave-chemo-immunostimulant Ce–Mn MOF for improved immunotherapy
Researchers developed a nanoparticle-based treatment that combines microwave energy, chemotherapy, and immune activation to reverse the protective environment that tumors create to hide from the immune system. In animal experiments, this combined approach significantly increased immune cell infiltration into tumors and improved the body's ability to fight cancer beyond the treated area.
Nanomaterials in Drug Delivery: Strengths and Opportunities in Medicine
This review covers how nanomaterials are being used to improve drug delivery for treating cancer and infections, offering better targeted therapy with fewer side effects. While not directly about microplastics, the research on how nanoparticles interact with human tissues provides insight into how similarly sized nanoplastics might behave once inside the body.
Unraveling the impact of nanoplastics on bone microenvironment: focus on extracellular vesicle-mediated communication and oxidative stress in multiple myeloma.
Researchers reviewed how nanoplastics affect the bone microenvironment, focusing on oxidative stress pathways and extracellular matrix disruption as key mechanisms of toxicity. Reactive oxygen species generated by nanoplastic exposure were identified as drivers of bone cell damage.
Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy
Researchers reviewed how engineering the protein corona — the layer of proteins that coats nanoparticles in biological fluids — through modifications like PEGylation and protein pre-coating can improve nanoparticle targeting for cancer drug delivery by controlling how immune cells recognize and clear the particles.
Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity
This review examines how nanotechnology-based approaches can regulate lipid metabolism in tumor microenvironments to enhance anti-cancer immune responses, covering lipid nanoparticles, liposomes, and other delivery systems. The authors identify lipid metabolic reprogramming as a promising immunotherapy target and nanotechnology as a key enabler for delivering therapeutics that reshape tumor-associated metabolic pathways.
Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance
This review explores how nanotechnology is being used to overcome drug resistance in cancer treatment, using materials like carbon nanotubes, dendrimers, and liposomes to deliver drugs more precisely to tumors. While not directly about microplastics, the nanomaterial strategies discussed share relevance with understanding how nano-sized plastic particles interact with human cells and tissues.
Effects of Combination Treatments with Astaxanthin-Loaded Microparticles and Pentoxifylline on Intracellular ROS and Radiosensitivity of J774A.1 Macrophages.
This study examined how astaxanthin-loaded microparticles combined with a drug affected reactive oxygen species levels and radiation sensitivity in immune cells. This is a cancer treatment research study with no direct connection to environmental microplastics.
The Immunotoxic Effects of Environmentally Relevant Micro- and Nanoplastics
Researchers characterized the immunotoxic effects of over 20 types of micro- and nanoplastic particles on macrophages and dendritic cells, finding that physicochemical properties such as size, shape, polymer type, and surface oxidation strongly influence immune cell responses.
Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells
This study found that nanoplastics are toxic to bone cells in mice, causing cell death, increased production of damaging reactive oxygen species, and disruption of the bone remodeling process. The nanoplastics impaired the ability of bone-building cells to migrate and promoted the formation of bone-destroying cells. These findings suggest that nanoplastic exposure could potentially contribute to bone diseases like osteoporosis, though more research in living animals and humans is needed.
The ancillary effects of nanoparticles and their implications for nanomedicine
Researchers reviewed 'ancillary effects' — the unintended biological interactions between nanoparticles and living systems that occur independent of engineered targeting or therapeutic functions — cataloguing how nanomaterial surface properties can modulate cell signaling, immune responses, and toxicity in ways that have major implications for nanomedicine safety and design.
The quest for nanoparticle-powered vaccines in cancer immunotherapy
This review explores how nanoparticles are being developed as cancer vaccine delivery systems to train the immune system to fight tumors more effectively. While focused on cancer immunotherapy rather than microplastics, the research highlights that understanding how nanoparticles interact with the immune system is crucial -- the same principles apply to understanding how nanoplastics may affect immune responses in the body.
Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review
Researchers reviewed how the physical and chemical properties of nanoparticles — including size, shape, surface charge, and material type — influence their toxicity in living cells and tissues, with relevance to both medical applications and environmental exposures like nanoplastics. Smaller particles are generally more toxic because they have greater surface area and can more easily penetrate cell membranes and trigger oxidative stress.
Enhanced Biocompatibility and Multifunctional Properties of Iron-Doped Zinc Oxide Nanoparticles for Applications
This materials science paper describes the synthesis and characterization of iron-doped zinc oxide nanoparticles for biomedical applications including drug delivery and imaging. The study is focused on nanomedicine and is not related to environmental microplastic research.
Converging frontiers in cancer treatment: the role of nanomaterials, mesenchymal stem cells, and microbial agents—challenges and limitations
This review examines three cutting-edge approaches to cancer treatment: nanomaterials for targeted drug delivery, mesenchymal stem cells as carriers for therapeutic agents, and microbial agents that can selectively attack tumors. Each approach aims to overcome the limitations of conventional treatments like chemotherapy and radiation, which often damage healthy tissue and lead to drug resistance. The authors discuss both the promise and the remaining challenges of bringing these innovative therapies into clinical practice.
Nanobiotics against antimicrobial resistance: harnessing the power of nanoscale materials and technologies
Researchers review how nanoscale materials — tiny particles engineered at the billionth-of-a-meter scale — offer a promising alternative to traditional antibiotics as bacteria develop resistance to conventional drugs. These "nanobiotics" can penetrate bacterial defenses and biofilms in ways that standard antibiotics cannot, potentially helping avert a global post-antibiotic health crisis.
Polyethylene microplastics trigger osteosarcoma progression via ITGA5/FAPα/LGMN cancer promoting complex: A novel environmental cancer promoting mechanism
Researchers identified polyethylene microplastics in human osteosarcoma tumor tissues using Raman spectroscopy and demonstrated that PE-MPs promoted cancer progression through activation of the ITGA5/FAPα/LGMN protein complex. The findings link environmental microplastic exposure to a specific molecular mechanism driving bone cancer progression.
Tumorigenic and tumoricidal properties of exosomes in cancers; a forward look
This review explores how tiny cell-released vesicles called exosomes can either promote or fight cancer by transferring signaling molecules between cells. While not directly about microplastics, the research is relevant because nanoplastics are similar in size to exosomes and may interfere with these important cell communication pathways. Understanding how nanoscale particles affect cell signaling could help explain some of the biological effects of nanoplastic exposure.
Application of Hydrogel as Drug Carrier in Tumor Therapy
This review summarizes recent advances in hydrogel-based drug delivery systems for cancer therapy, focusing on their ability to achieve controlled drug release and respond to tumor microenvironment signals for targeted treatment.