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Reversing the immunosuppressive microenvironment with reduced redox level by microwave-chemo-immunostimulant Ce–Mn MOF for improved immunotherapy
Summary
Researchers developed a nanoparticle-based treatment that combines microwave energy, chemotherapy, and immune activation to reverse the protective environment that tumors create to hide from the immune system. In animal experiments, this combined approach significantly increased immune cell infiltration into tumors and improved the body's ability to fight cancer beyond the treated area.
Our in vivo experimental results demonstrate that the microwave-chemo-immunostimulant CMMCP significantly enhances the T cell infiltration and thus improves the antitumor effect. This study presents an easy, safe, and effective strategy for a whole-body antitumor effect after local treatment.
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