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61,005 resultsShowing papers similar to Preliminary Study on the Toxic Effects of Polystyrene Microplastics in Human Colorectal Cells
ClearPreliminary Study on the Toxic Effects of Polystyrene Microplastics in Human Colorectal Cells
Researchers evaluated the toxic effects of polystyrene microplastics in two sizes, 80 nanometers and 500 nanometers, on human colorectal cells in laboratory culture. They found that both sizes significantly reduced cell viability, induced cell death, and disrupted the normal cell cycle in a dose-dependent manner. The study provides preliminary evidence that microplastic particles at sizes relevant to human exposure may pose risks to intestinal cell health.
The potential effects of microplastic pollution on human digestive tract cells
Researchers tested polystyrene particles of four different sizes on human colon and small intestine cells to assess the potential effects of microplastic ingestion. They found that the smallest nanoscale particles were more readily taken up by cells and caused greater reductions in cell viability and increased oxidative stress. The study suggests that smaller plastic particles may pose a greater risk to the human digestive tract than larger ones.
The effects of polystyrene microplastics on human intestinal cells health and function
This study examined how polystyrene microplastics affect normal and cancer intestinal cells, addressing a gap left by previous research that used only cancer cell lines and pristine plastics. The work evaluated microplastic toxicity under more realistic conditions including digestive system biotransformation, assessing effects on nutrient uptake and cellular function.
Pro-Inflammatory and Cytotoxic Effects of Polystyrene Microplastics on Human and Murine Intestinal Cell Lines
Researchers tested the effects of polystyrene microplastics on human and mouse intestinal cell lines. They found that microplastic exposure increased cell death and triggered inflammatory responses, including the release of inflammatory signaling molecules. The study suggests that microplastics may promote inflammation in the gut lining, which could have implications for digestive health.
Elucidating the Size‐Dependency of In Vitro Digested Polystyrene Microplastics on Human Intestinal Cells Health and Function
Polystyrene microplastics of different sizes were subjected to simulated in vitro digestion and then applied to human intestinal cells, with smaller particles causing greater disruption to cell health and barrier function than larger ones. The results suggest that the smallest microplastics reaching the human gut pose the greatest risk to intestinal integrity.
The Toxic Effects of Polystyrene Microplastics on Colonic Epithelial NCM460 Cells
This study compared the effects of original versus pigment-marked polystyrene microplastics on NCM460 colonic epithelial cells at multiple concentrations, finding that both particle types caused dose-dependent cytotoxicity and that pigments added to facilitate tracking influenced cellular responses.
Nanoplastics as a potential environmental health factor: effects of polystyrene nanoparticles on human intestinal epithelial Caco-2 cells
Researchers tested how polystyrene nanoparticles interact with human intestinal cells in the lab. They found that the nanoparticles were readily taken up by the cells in a concentration-dependent manner, but no significant toxic effects were observed under the conditions tested. The study suggests that while nanoplastics can enter gut cells, their short-term toxicity at the tested levels appears limited.
Influence of the digestive process on intestinal toxicity of polystyrene microplastics as determined by in vitro Caco-2 models
Researchers studied how the human digestive process transforms polystyrene microplastics and affects their intestinal toxicity using in vitro Caco-2 cell models. The study found that digestion formed a corona on microplastic surfaces without altering their chemical composition, and that smaller particles (100 nm) showed higher toxicity than larger ones (5 micrometers) regardless of digestive treatment.
Effects of bisphenol A and nanoscale and microscale polystyrene plastic exposure on particle uptake and toxicity in human Caco-2 cells
Researchers studied how human intestinal Caco-2 cells take up polystyrene plastic particles of five different sizes ranging from 300 nanometers to 6 micrometers. The study found that smaller particles were taken up at higher rates and that co-exposure with bisphenol A increased cellular toxicity, suggesting that nanoscale plastics may pose a greater risk to human intestinal cells than larger microplastics.
Nano-plastics and gastric health: Decoding the cytotoxic mechanisms of polystyrene nano-plastics size
Researchers examined how different sizes of polystyrene nanoplastics affect human stomach cells in the laboratory. They found that smaller nanoplastics were more readily taken up by the cells and caused greater damage, including increased oxidative stress and reduced cell survival. The study suggests that nanoplastic particle size plays a critical role in determining their potential impact on gastrointestinal health.
Size-dependent toxicity of polystyrene microplastics on the gastrointestinal tract: Oxidative stress related-DNA damage and potential carcinogenicity
Researchers found that polystyrene microplastics accumulate mainly in stomach tissue, where smaller nanoscale particles cause more severe damage than larger ones. The nanoplastics reduced antioxidant enzyme activity, increased DNA damage markers, and activated signaling pathways associated with cancer development. These size-dependent effects on the gastrointestinal tract suggest that the smallest plastic particles may pose the greatest risk to digestive health.
Acute and Sub-Chronic Effects of Microplastics (3 and 10 µm) on the Human Intestinal Cells HT-29
Researchers tested the effects of polystyrene microplastics on human intestinal cells over both short-term and extended 48-day exposure periods, simulating real-world chronic exposure. They found that smaller 3-micrometer particles caused more pronounced damage to cell membranes, while larger 10-micrometer particles generated more oxidative stress. The study suggests that prolonged microplastic exposure could contribute to intestinal health issues due to cumulative cell damage over time.
Size-dependent effects of polystyrene microplastics on cytotoxicity and efflux pump inhibition in human Caco-2 cells
Researchers compared how two sizes of polystyrene microplastics affect human intestinal cells grown in the lab. While both sizes showed low direct toxicity, they disrupted mitochondrial function and inhibited important cellular transport pumps that normally help remove harmful substances from cells. The findings suggest that microplastics in the gut could interfere with how intestinal cells handle drugs and toxins, even at concentrations that do not cause obvious cell damage.
Effects of Polystyrene Microplastics on Human Kidney and Liver Cell Morphology, Cellular Proliferation, and Metabolism
Researchers exposed human kidney and liver cells to polystyrene microplastics of different sizes and concentrations to assess their effects on cell health. They found that microplastics altered cell shape, reduced proliferation, and disrupted cellular metabolism, with smaller particles generally causing more damage. The findings suggest that microplastics reaching internal organs could have measurable effects at the cellular level.
Micro-sized polyethylene particles affect cell viability and oxidative stress responses in human colorectal adenocarcinoma Caco-2 and HT-29 cells
Researchers tested the effects of micro-sized polyethylene particles on two types of human colon cancer cells commonly used in gut research. The microplastics reduced cell survival and triggered oxidative stress, which is a type of cellular damage caused by an imbalance of harmful molecules. This study provides evidence that microplastics reaching the human gut through food and water could damage intestinal cells, though more research is needed at real-world exposure levels.
Uptake and toxicity of polystyrene micro/nanoplastics in gastric cells: Effects of particle size and surface functionalization
Researchers evaluated the uptake and toxicity of polystyrene micro- and nanoplastics in human gastric cells, comparing different sizes and surface treatments. The study found that smaller 50-nanometer particles were taken up at significantly higher rates, with positively charged aminated particles being the most toxic, causing cytotoxicity at lower concentrations and higher rates of cell death.
Study on the Toxic Effects of Nanoplastics on Colonic Epithelial NCM460 Cells
Polystyrene (PS-100) and amino-functionalized polystyrene (NH2-PS-100) nanoplastics at 100 nm were tested on NCM460 normal human colorectal mucosal cells, finding concentration- and surface-chemistry-dependent cytotoxicity—with amino-functionalized particles showing greater toxicity—contributing to the mechanistic understanding of nanoplastic intestinal cell effects.
Polystyrene Microplastics of Varying Sizes and Shapes Induce Distinct Redox and Mitochondrial Stress Responses in a Caco-2 Monolayer
Researchers tested three sizes and shapes of polystyrene microplastics on human intestinal cells and found that all were taken up by the cells, with the smallest particles (200 nm) causing the most pronounced effects on cellular stress responses. The microplastics triggered changes in antioxidant gene expression and mitochondrial activity. The study suggests that the number of particles a cell absorbs, driven largely by particle size, determines the severity of the stress response.
Noxic effects of polystyrene microparticles on murine macrophages and epithelial cells
Polystyrene microparticles induced cytotoxic effects in murine macrophages and intestinal epithelial cells at higher concentrations, triggering cell membrane damage, inflammatory cytokine release, and reduced phagocytic function, with smaller particles generally causing greater harm than larger ones at equivalent mass doses.
Polystyrene micro and nano-particles induce metabolic rewiring in normal human colon cells: A risk factor for human health
Researchers exposed normal human colon cells to polystyrene micro and nanoplastic particles and observed significant metabolic changes in the cells. The study found that these plastic particles altered energy metabolism and cellular pathways in ways that could increase vulnerability to disease. These findings raise concerns that routine ingestion of microplastics through contaminated food may affect normal intestinal cell function in humans.
Biological effects of polystyrene micro- and nano-plastics on human intestinal organoid-derived epithelial tissue models without and with M cells.
Researchers exposed human intestinal organoid-derived epithelial tissue models with and without M cells to polystyrene micro- and nano-plastics, finding that nano-plastics caused greater disruption of barrier integrity and uptake than micro-plastics, and that M cell-containing models showed enhanced particle translocation compared to standard epithelial models.
Adverse effect of polystyrene microplastics (PS-MPs) on tube formation and viability of human umbilical vein endothelial cells
Researchers tested the effects of polystyrene microplastics on human blood vessel cells grown in the laboratory and found that the particles reduced cell survival and inhibited the formation of new blood vessel structures. Smaller microplastics accumulated inside the cells more readily and triggered cell death through autophagy and necrosis. The study suggests that microplastics entering the bloodstream could potentially interfere with normal vascular function.
Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo
Researchers studied the uptake and effects of orally ingested polystyrene microplastic particles using human intestinal cell models and rodent experiments. They found that smaller microplastics were taken up by intestinal cells and could cross the gut barrier, though the majority passed through the digestive system. The study suggests that while most ingested microplastics are excreted, a fraction can be absorbed, warranting further investigation into long-term health effects.
Investigation of potential toxic effects of nano- and microplastics on human endometrial stromal cells
Researchers exposed human endometrial cells (uterine lining cells) to polystyrene nano- and microplastics and found that smaller particles (100 nanometers) were taken up most readily, accumulating in both the nucleus and cytoplasm. At higher concentrations, the nanoplastics reduced cell growth and triggered cell death. These findings suggest that nanoplastics could pose a risk to uterine health and potentially affect fertility and pregnancy outcomes.