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Papers
20 resultsShowing papers similar to Immune Disruption and Disease Development by Microplastic Exposure
ClearEffect of micro- and nanoplastics as food contaminants on the immune system
This review synthesized research on how microplastic and nanoplastic exposure affects immune system function, finding evidence across multiple studies that these particles can modulate immune responses and trigger inflammatory pathways in exposed organisms. The authors highlight immune disruption as an emerging health concern from micro- and nanoplastic contamination.
Micro- and Nanoplastics and the Immune System: Mechanistic Insights and Future Directions
This review summarizes how micro- and nanoplastics disrupt the human immune system at the cellular level, impairing key immune cells like macrophages, dendritic cells, and T cells. The particles trigger chronic low-grade inflammation through oxidative stress and activation of inflammatory pathways, and can worsen autoimmune conditions like lupus and inflammatory bowel disease in animal studies. These findings raise concerns that ongoing microplastic exposure could gradually weaken immune function and contribute to immune-related diseases in people.
The Emerging Threat of Micro- and Nanoplastics on the Maturation and Activity of Immune Cells
This review examines how micro and nanoplastics affect the immune system, focusing on their impact on immune cell development and function. Studies show that these tiny plastic particles can alter how immune cells mature and respond to threats, potentially weakening the body's defenses or triggering excessive inflammation. Since humans are constantly exposed to microplastics through food, water, and air, understanding these immune effects is critical for assessing long-term health risks.
The Micronanoplastics-immune axis across organ systems: towards a research agenda
This review synthesizes current evidence on how micro- and nanoplastics interact with the immune system across multiple organ systems in the human body. Researchers examined the primary routes of exposure through inhalation, ingestion, and dermal contact, as well as the cellular mechanisms involved in immune response. The study highlights that microplastic-immune interactions may contribute to chronic inflammation and immune dysregulation, pointing to a need for standardized research frameworks.
Immunotoxicity by Microplastics
This review examines how microplastics and nanoplastics, after entering the body through the gut, lungs, or skin, can disrupt the immune system by triggering inflammation, causing oxidative stress (cellular damage from unstable molecules), and impairing immune cell function, while highlighting major gaps in our understanding of these long-term health effects.
Impacts of microplastics on immunity
This review examines the growing evidence that microplastics and nanoplastics can affect the immune system, covering studies in marine organisms, mammals, and human cell lines. Researchers found that these particles can trigger inflammation, alter immune cell function, and disrupt immune signaling pathways. The study underscores the need for more immunological research to fully understand how plastic particle exposure may compromise immune health in humans.
Nanoplastics and Immune Disruption: A Systematic Review of Exposure Routes, Mechanisms, and Health Implications
This systematic review found that nanoplastics — extremely tiny plastic particles — can cross biological barriers and disrupt immune function in laboratory studies. The evidence suggests these particles may trigger inflammation and could potentially contribute to autoimmune conditions, though human studies are still limited.
Autoimmune Diseases and Microplastic Pollution: Joining the Dots
This review examines the emerging literature connecting microplastic pollution with autoimmune disease development, discussing mechanisms by which plastic particles and their chemical additives could trigger immune dysregulation. The authors identify oxidative stress, gut microbiome disruption, and molecular mimicry as plausible pathways linking chronic microplastic exposure to autoimmune conditions.
Unraveling the impact of microplastics on autoimmune diseases: hidden dangers and environmental triggers
This review examines the emerging evidence linking microplastic exposure to the development and progression of autoimmune disorders. Researchers found that microplastics can modulate immune gene expression, trigger excessive reactive oxygen species in immune cells, and promote inflammatory cytokine release, potentially creating conditions favorable for autoantibody production. The study highlights microplastics as a plausible environmental trigger for autoimmune conditions, though direct causal evidence in humans remains limited.
Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature
This review examines the evidence on how nano- and microplastics affect the immune system and intestinal health. The findings suggest that exposure to these particles can disrupt the gut microbiome and impair critical intestinal barrier functions, potentially contributing to the development of chronic inflammatory and immune conditions.
The impact of micro- and nanoplastics on immune system development and functions: Current knowledge and future directions
This review summarizes existing research on how micro- and nanoplastics affect the immune system, finding that exposure can disrupt blood cell development, alter immune cell behavior, and trigger inflammatory responses in lab and animal studies. While some studies show significant effects on organs like the spleen and intestines, others found minimal impact at environmentally realistic exposure levels, highlighting the need for more standardized research.
Effects of microplastics on the immune system: How much should we worry?
This review examines how microplastics may affect the human immune system, noting that people are mainly exposed through food and breathing. While early research shows microplastics can trigger inflammation and immune responses in lab and animal studies, the authors stress that more research is needed to understand what this means for human health at real-world exposure levels.
Micro- and Nanoplastics and the Immune System: Mechanistic Insights and Future Directions
This review synthesizes experimental evidence on how micro- and nanoplastics disrupt immune system function, documenting effects on macrophages, dendritic cells, neutrophils, and T and B cells across multiple organs including the placenta, lungs, blood, and brain. The authors identify key mechanistic pathways and call for standardized exposure studies to clarify real-world health risks.
A Systematic Review on the Impact of Micro-Nanoplastics Exposure on Human Health and Diseases
This systematic review summarizes existing research on how micro and nanoplastic exposure affects human health and may contribute to disease. The evidence suggests that these tiny particles can enter the body through food, water, air, and even cosmetics, potentially causing inflammation, oxidative stress, and disruptions to the immune and reproductive systems.
Micro and Nanoplastics on Human Health and Diseases: Perspectives and Recent Advances
This review covers how micro- and nanoplastic particles enter the human body through ingestion, inhalation, infusion, and skin absorption, distribute to virtually all tissues and organs via the circulatory system, and cause health impacts including inflammatory responses, cellular damage, and endocrine disruption.
Potential Human Health Impacts of Microplastics and Associated Chemicals
This book chapter reviews human exposure pathways to microplastics — including ingestion, inhalation, and dermal contact — and examines evidence linking tissue-level MP accumulation to inflammation, immune disruption, endocrine effects, and potential carcinogenicity.
The Impact of Microplastics and Nanoplastics on Human Health: A Follow-Up Study Focusing on Endocrine, Nervous, and Immune Systems
This review examines evidence for microplastic and nanoplastic impacts on the endocrine, nervous, and immune systems, documenting how particles detected in human organs can disrupt hormone signaling, induce neuroinflammation, and alter immune function.
Potential Health Impact of Microplastics: A Review of Environmental Distribution, Human Exposure, and Toxic Effects
This review summarizes existing research on how microplastics are found throughout the environment and in human samples, entering the body through food, air, and skin contact. Lab studies in cells and animals show microplastics can cause oxidative stress, DNA damage, immune reactions, brain toxicity, and reproductive harm, and early human health data links microplastic exposure to several chronic diseases.
Micro- and Nanoplastics on Human Health and Diseases: Perspectives and Recent Advances
This review provides a comprehensive overview of how micro- and nanoplastics enter the human body through ingestion, inhalation, and skin absorption, and how they can then travel through the bloodstream to reach virtually every organ. Researchers summarize evidence that these particles can trigger inflammation, oxidative stress, and disruption of hormonal and immune functions. The study emphasizes that the ability of these particles to cross biological barriers and accumulate in tissues makes understanding their long-term health effects an urgent research priority.
Cellular Impact of Micro(nano)plastics on Human Health: A Review.
This review examined how micro(nano)plastics (MNPs) entering the human body through ingestion, inhalation, and skin contact affect cells and tissues. It synthesized evidence of oxidative stress, inflammation, DNA damage, and endocrine disruption associated with MNP exposure.