Papers

61,005 results
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Article Tier 2

First insight of the intergenerational effects of tri-n-butyl phosphate and polystyrene microplastics to Daphnia magna

Researchers studied the combined effects of polystyrene microplastics and the flame retardant tributyl phosphate on water fleas across multiple generations. They found that co-exposure caused more severe impacts on survival, growth, and reproduction than either contaminant alone, with effects persisting into subsequent generations. The study suggests that microplastics carrying adsorbed chemicals may pose compounding risks to aquatic organisms over time.

2024 The Science of The Total Environment 7 citations
Article Tier 2

Combined effect of microplastics and tire particles on Daphnia magna: Insights from physiological and transcriptomic responses

Researchers investigated the combined effects of microplastics and tire particles on the water flea Daphnia magna, finding that the mixture triggered significant oxidative stress at environmentally relevant concentrations. Transcriptomic analysis revealed upregulation of antioxidant and metabolic stress genes, while energy reserves like glycogen were affected. The study suggests that co-exposure to these common freshwater pollutants may pose greater ecological risks than either particle type alone.

2025 Environmental Pollution 1 citations
Article Tier 2

Combined toxic effects of polystyrene microplastic and benzophenone-4 on the bioaccumulation, feeding, growth, and reproduction of Daphnia magna

Researchers examined the combined toxic effects of polystyrene microplastics and the UV filter chemical benzophenone-4 on water fleas over 21 days. They found that exposure to both contaminants together caused greater harm to feeding, growth, and reproduction than either pollutant alone. The study demonstrates that microplastics and personal care product chemicals can interact to amplify their negative effects on freshwater organisms.

2024 Environmental Pollution 7 citations
Article Tier 2

Detrimental effects of individual versus combined exposure to tetrabromobisphenol A and polystyrene nanoplastics in fish cell lines

Researchers tested how combined exposure to the flame retardant tetrabromobisphenol A and polystyrene nanoparticles affects freshwater fish cells. They found that co-exposure to even low concentrations of both pollutants caused subtle changes in cell viability and generated oxidative DNA damage. The study suggests that the interaction between nanoplastics and chemical pollutants in aquatic environments may pose compounding risks to fish health.

2023 Environmental Toxicology and Pharmacology 19 citations
Article Tier 2

Combined toxicity of perfluoroalkyl substances and microplastics on the sentinel species Daphnia magna: Implications for freshwater ecosystems

This study tested how PFAS chemicals (common industrial pollutants) and PET microplastics affect water fleas, both alone and together. The combination caused worse developmental and reproductive problems than either pollutant alone, and organisms with prior chemical exposure history responded differently, showing that microplastics can amplify the harm of other environmental contaminants in ways that are difficult to predict.

2024 Environmental Pollution 37 citations
Article Tier 2

Combined Toxicity of Polystyrene Nanoplastics and Pyriproxyfen to Daphnia magna

Researchers evaluated the combined toxic effects of polystyrene nanoplastics and the insecticide pyriproxyfen on the water flea Daphnia magna under both acute and chronic exposure conditions. They found that nanoplastics initially reduced the acute toxicity of the pesticide within 24 hours but worsened chronic effects over longer periods. The study suggests that nanoplastics can alter how other environmental contaminants affect aquatic organisms, complicating risk assessments.

2024 Sustainability 3 citations
Article Tier 2

Combined Effects of Polystyrene Nanoplastics and Enrofloxacin on the Life Histories and Gut Microbiota of Daphnia magna

Researchers exposed Daphnia magna to polystyrene nanoplastics and the antibiotic enrofloxacin alone and in combination, measuring life history traits and gut microbiota responses. Both stressors individually reduced survival and reproduction, and combined exposure altered the taxonomic composition and metabolic function of gut microbiota more than either contaminant alone.

2022 Water 19 citations
Article Tier 2

Co-exposure of microplastics and 2-methoxy-1,4-naphthoquinone affects Daphnia magna depending on the developmental stage

Researchers studied the combined effects of microplastics and the plant-derived compound 2-methoxy-1,4-naphthoquinone on Daphnia magna, which represents a freshwater ecosystem stress scenario. Co-exposure produced effects that differed from either stressor alone, highlighting the importance of studying pollutant mixtures.

2024 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Synergistic effect of microplastic fragments and benzophenone‐3 additives on lethal and sublethal Daphnia magna toxicity

Researchers assessed the combined effects of polyethylene microplastic fragments and the UV-filter additive benzophenone-3 on the water flea Daphnia magna. They found that microplastic fragments were significantly more acutely toxic than the dissolved additive alone, and the combination produced synergistic lethal and sublethal effects. The study highlights that microplastic particles carrying chemical additives may pose greater risks to aquatic invertebrates than either stressor in isolation.

2020 Journal of Hazardous Materials 120 citations
Article Tier 2

Study of the toxicological effects of emerging contaminants on Daphnia similis associating polyethylene microplastics with the agrochemical imidacloprid.

Brazilian researchers tested the ecotoxicological effects of combining polyethylene microplastics with the insecticide imidacloprid on the freshwater crustacean Daphnia, finding combined exposures were more toxic than either pollutant alone. These results suggest that microplastics and pesticides together pose greater risks to aquatic organisms than studies of single pollutants indicate.

2023 Digital Library of Theses and Dissertations (Universidade de São Paulo)
Article Tier 2

The combined toxicity test of polyester and tetra ethylene glycol on Daphnia magna

This study tested the combined toxicity of polyester microplastics and tetraethylene glycol on the water flea Daphnia magna, a standard freshwater toxicity test organism. The combined exposure was more harmful than either substance alone, highlighting the risks of plastic-chemical mixtures in aquatic environments.

2021
Article Tier 2

Toxicological effects of microplastics and phenanthrene to zebrafish (Danio rerio)

Researchers exposed zebrafish to polystyrene microplastics, the pollutant phenanthrene, and a combination of both to assess their toxicity over 24 days. They found that co-exposure amplified oxidative stress, suppressed immune gene expression, and significantly disrupted the gut microbiome compared to either contaminant alone. The study suggests that microplastics can worsen the toxic effects of organic pollutants in aquatic organisms by altering how chemicals accumulate and interact in the body.

2020 The Science of The Total Environment 190 citations
Article Tier 2

Combined effects of microplastics and benzo[a]pyrene on Asian sea bass Lates calcarifer growth and expression of functional genes

Researchers exposed juvenile Asian sea bass to polyethylene microplastics and the carcinogen benzo[a]pyrene, both individually and in combination, over 56 days. They found that co-exposure caused more severe effects on growth and gene expression related to immune function and stress response than either contaminant alone. The study highlights that microplastics may worsen the toxic effects of chemical pollutants already present in marine environments.

2024 Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology 7 citations
Article Tier 2

Metabolomic analysis of combined exposure to microplastics and methylmercury in the brackish water flea Diaphanosoma celebensis

Combined exposure of the brackish water flea Diaphanosoma celebensis to microplastics and methylmercury produced metabolomic disruptions greater than either pollutant alone, with the combination altering amino acid metabolism, energy pathways, and oxidative stress markers. The study provides molecular-level evidence that microplastic-mercury co-contamination poses synergistic risks to aquatic invertebrates.

2022 Environmental Geochemistry and Health 14 citations
Article Tier 2

An Ecotoxicological Assessment of the Impact of Microplastics on Daphnia magna using Acute and Chronic Toxicity Endpoints with a Focus on Stress Behaviour

Laboratory tests on Daphnia magna (a key freshwater zooplankton) found that polyethylene microbeads alone at environmentally realistic concentrations did not cause significant harm, but when combined with the antimicrobial chemical triclocarban, microplastics appeared to increase toxicity. This suggests microplastics may act as carriers that enhance the effects of co-pollutants even when the plastics themselves seem harmless in isolation.

2023
Article Tier 2

An Ecotoxicological Assessment of the Impact of Microplastics on Daphnia magna using Acute and Chronic Toxicity Endpoints with a Focus on Stress Behaviour

Laboratory tests on Daphnia magna (a key freshwater zooplankton) found that polyethylene microbeads alone at environmentally realistic concentrations did not cause significant harm, but when combined with the antimicrobial chemical triclocarban, microplastics appeared to increase toxicity. This suggests microplastics may act as carriers that enhance the effects of co-pollutants even when the plastics themselves seem harmless in isolation.

2023 1 citations
Article Tier 2

Acute toxicity of triclosan, caffeine, nanoplastics, microplastics, and their mixtures on Daphnia magna

Researchers tested the acute toxicity of triclosan, caffeine, nanoplastics, and microplastics individually and in mixtures on the water flea Daphnia magna. They found that nanoplastics were more toxic than microplastics, and mixtures of these pollutants with triclosan or caffeine produced varying levels of combined toxicity. The study highlights that environmental pollutants rarely occur in isolation, and their mixtures may have unpredictable effects on aquatic organisms.

2023 Marine Pollution Bulletin 29 citations
Article Tier 2

Insights into the synergistic toxicity mechanisms caused by nano- and microplastics with triclosan using a dose-dependent functional genomics approach in Saccharomyces cerevisiae

Researchers used yeast functional genomics to investigate the combined toxicity of polystyrene nano- and microplastics with the antimicrobial compound triclosan. They found that the combined exposure produced synergistic toxic effects that were more harmful than either contaminant alone, disrupting cellular processes related to membrane integrity and protein function. The study provides molecular-level evidence that microplastics may amplify the toxicity of co-occurring chemical pollutants.

2024 Chemosphere 3 citations
Article Tier 2

Co-exposure of microplastics and 2-methoxy-1,4-naphthoquinone affects Daphnia magna depending on the developmental stage

Researchers examined the combined effects of microplastic exposure and the naturally occurring chemical 2-methoxy-1,4-naphthoquinone on Daphnia magna, investigating how plastic particles interact with an invasive species-linked chemical stressor in freshwater. Co-exposure produced different effects than either stressor alone, illustrating how microplastics complicate toxicity in multi-stressor freshwater environments.

2024 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Microplastics and plastic additives as contaminants of emerging concern: A multi-biomarker approach using Rhinella arenarum tadpoles

Researchers exposed toad tadpoles to polyethylene microplastics and the flame retardant TBBPA, both alone and in combination, for 30 days. They found that the mixture produced different toxic effects than either substance alone, affecting growth, enzyme activity, and cellular stress markers. The study highlights the importance of studying microplastics alongside common plastic additives, since their combined effects may differ from individual exposures.

2023 Environmental Advances 17 citations
Article Tier 2

Impacts of microplastics and pesticides on Daphnia

Researchers investigated the combined and individual impacts of microplastics and pesticides on Daphnia magna, a model crustacean widely used in freshwater ecotoxicology, to assess how these co-occurring pollutants affect aquatic ecosystem health. The study examined survival, reproduction, and physiological responses in D. magna exposed to varying concentrations of both stressors under controlled conditions.

2025 Fisher Digital Publications (St. John Fisher College)
Article Tier 2

Initial evaluation of the combined effects of nanoplastics and 17α-ethinylestradiol on D. magna

This laboratory study examined the combined effects of polystyrene nanoplastics and the synthetic estrogen ethinylestradiol on small aquatic organisms, finding that the combination had different effects than either contaminant alone. The results suggest that nanoplastics can modify how other environmental pollutants affect aquatic life, complicating risk assessment for real-world multi-contaminant exposures.

2017 Lund University Publications Student Papers (Lund University)
Article Tier 2

Nanopolystyrene size effect and its combined acute toxicity with halogenated PAHs on Daphnia magna

Researchers tested how nanopolystyrene particle size affects toxicity to Daphnia magna water fleas alone and in combination with halogenated polycyclic aromatic hydrocarbons, finding smaller particles (30 nm) were far more toxic than larger ones (1 µm) and that the plastic-chemical mixtures showed antagonistic effects — reducing combined toxicity below what either contaminant caused alone.

2023 The Science of The Total Environment 10 citations
Article Tier 2

The interfacial interaction between Dechlorane Plus (DP) and polystyrene nanoplastics (PSNPs): An overlooked influence factor for the algal toxicity of PSNPs

Researchers investigated how a flame retardant chemical called Dechlorane Plus interacts with polystyrene nanoplastics and found that the two pollutants bind together and become more harmful to algae than either one alone. When exposed to both contaminants simultaneously, algae showed reduced photosynthesis, greater growth inhibition, and significantly increased oxidative damage. The study suggests that the combined effects of nanoplastics and their chemical additives pose greater environmental risks than previously recognized.

2023 The Science of The Total Environment 15 citations