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61,005 resultsShowing papers similar to [Effects of microplastics exposure in development of mineralized tissues].
ClearBridging relevance between microplastics, human health and bone metabolism: Emerging threats and research directions
Researchers reviewed how microplastics — tiny plastic fragments that accumulate in tissues throughout the body — may disrupt bone metabolism by triggering inflammation, oxidative stress, and hormonal interference, raising concern that widespread microplastic exposure could contribute to bone diseases like osteoporosis.
Potential threats of environmental microplastics to the skeletal system: current insights and future directions
This review summarizes emerging evidence that micro- and nanoplastics may reach the skeletal system through the bloodstream and accumulate in bone tissue. Researchers highlight potential effects on bone-forming and bone-resorbing cells, which could disrupt normal bone maintenance. The study calls attention to an underexplored area of microplastic health research and outlines directions for future investigation.
Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells.
Researchers investigated how nanoplastics affect the bone microenvironment using murine bone cell models, examining effects on osteoblast and osteoclast activity that regulate bone formation and resorption. Nanoplastic exposure disrupted bone cell function, raising concerns about skeletal health impacts from daily plastic particle exposure.
Microplastics in Musculoskeletal Disorders: An Emerging Threat
This review examines the emerging evidence that microplastics may affect the musculoskeletal system, including bones, cartilage, and muscles. Researchers found that microplastics can enter the body through ingestion, inhalation, and skin absorption, potentially triggering oxidative stress and inflammation in musculoskeletal tissues. The study suggests that more research is needed to understand the long-term impacts of microplastic exposure on bone and joint health.
Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells.
This study examined how nanoplastics affect bone cell function in a murine model, investigating effects on osteoblasts and osteoclasts that govern bone formation and resorption in the bone microenvironment. Nanoplastic exposure altered bone cell activity, suggesting that daily plastic particle exposure could have long-term implications for bone health.
Effects of microplastics on the bones: a comprehensive review
This comprehensive review examines the growing evidence that micro- and nanoplastics can affect bone health, with researchers recently detecting plastic particles in human bone tissue for the first time. Lab studies show that microplastics can trigger inflammation, increase bone-resorbing cell activity, impair bone-forming cells, and weaken bone structure in animal models. While direct links to human bone conditions like osteoporosis have not yet been confirmed, the accumulating evidence suggests that microplastic exposure may represent a new risk factor for skeletal health.
Effects of Polystyrene Microplastics on Bone-related Protein Expression, Mineralization Capacity, and Mitochondrial Function in Osteoblast-like Cells (mg-63)
Osteoblast-like cells (MG-63) were exposed to polystyrene microplastics at 5–50 µg/mL, and bone-related protein expression, mineralisation capacity, and mitochondrial function were assessed. PS-MPs were internalised and reduced mineralisation and osteocalcin levels while impairing mitochondrial bioenergetics, suggesting microplastics may negatively affect bone cell function.
Polystyrene microplastics disrupt skeletal development in marine medaka Oryzias melastigma
This study exposed marine medaka (Oryzias melastigma) to polystyrene microplastics for 28 days and found dose-dependent impairment of skeletal development, including reduced bone mineralization and deformed vertebral structures. The results suggest that chronic MP exposure during development can disrupt normal bone formation in fish.
Polystyrene microplastics arrest skeletal growth in puberty through accelerating osteoblast senescence
Researchers found that polystyrene microplastics accumulated in the bones of mice during puberty, leading to reduced body and bone length and impaired bone structure. The microplastics accelerated premature aging (senescence) of bone-building cells called osteoblasts, suppressing their ability to form new bone. The study suggests that microplastic exposure during critical growth periods may pose a risk to skeletal development.
Unraveling the impact of nanoplastics on bone microenvironment: focus on extracellular vesicle-mediated communication and oxidative stress in multiple myeloma.
Researchers reviewed how nanoplastics affect the bone microenvironment, focusing on oxidative stress pathways and extracellular matrix disruption as key mechanisms of toxicity. Reactive oxygen species generated by nanoplastic exposure were identified as drivers of bone cell damage.
Microplastics in human skeletal tissues: Presence, distribution and health implications
This study is the first to find microplastics in human bones, cartilage, and spinal discs, with the highest concentrations found in spinal discs. The most common plastics detected were polypropylene and polystyrene, and animal experiments confirmed that microplastics can reach skeletal tissues through the bloodstream. Exposure triggered inflammatory markers in the blood, suggesting microplastics in bones could contribute to skeletal health problems.
The Effects of Microplastics on Musculoskeletal Disorder; A Narrative Review
This review summarizes emerging research on how microplastics affect bones and muscles. Studies have shown that microplastics can disrupt the cells responsible for bone growth and repair, and in muscles they can reduce fiber density, impair blood vessel formation, and cause tissue wasting. While research is still limited, the findings suggest microplastics could contribute to musculoskeletal problems, and the authors call for more studies using human tissues.
Microplastic Release from Dental Materials: Environmental and Biological Implications
This review examines how dental materials—composites, adhesives, denture bases, and orthodontic appliances—degrade under mechanical, thermal, enzymatic, and chemical stressors to release microplastics, contributing to both direct patient exposure and environmental contamination.
Microplastics as an emerging driver of osteoarthritis: a translational synthesis of environmental exposure, patho-mechanisms, and public health implications
A translational synthesis of clinical and experimental data examined the role of microplastic exposure in osteoarthritis (OA) development, finding evidence that MPs bioaccumulate in joint tissues and may promote inflammation and oxidative damage that disrupts cartilage homeostasis. The review identified MP exposure as a plausible but underexplored contributor to OA progression.
Unraveling the impact of nanoplastics on bone microenvironment: focus on extracellular vesicle-mediated communication and oxidative stress in multiple myeloma.
This study reviewed how nanoplastic particles disrupt the bone microenvironment through oxidative stress and damage to the extracellular matrix. Reactive oxygen species generated by nanoplastic exposure were found to drive toxicity in bone cells.
What every dentist needs to know about microplastics and dental materials.
This review outlined how common dental products — including toothpastes, composites, orthodontic appliances, and floss — contain or generate microplastics through degradation and use, and summarized the health risks from exposure via ingestion, inhalation, and dermal contact.
Micro- and nanoplastics: Emerging environmental threats to the Developmental Origins of Health and Disease
This review examines how micro- and nanoplastic exposure may contribute to chronic health conditions through the lens of developmental origins of health and disease. Evidence suggests that microplastics accumulate in human metabolic and reproductive tissues and may induce physiological and epigenetic changes that could potentially be inherited by future generations, though research into these mechanisms is still in early stages.
Combined exposure to microplastics and tetracycline leads to impaired skeletal development in young mice by the microbiota gut bone axis
Young mice co-exposed to microplastics and tetracycline antibiotic for 8 weeks showed significantly worse bone development than those exposed to either alone, driven by gut microbiota dysbiosis and disruption of the gut-bone axis.
Review: Microplastics: A threat for developing and repairing organs? — R1/PR8
This review synthesizes evidence on how micro- and nanoplastics (MNPs) affect organ development and repair processes in humans and laboratory rodents, noting that MNPs have been detected in virtually every human tissue including the placenta. Early developmental windows are particularly vulnerable because MNPs and their chemical additives can disrupt genome programming and hormonal signaling during critical growth phases. The review concludes that MNPs and their leached chemicals can impair both normal development and the healing processes that reuse developmental pathways after injury.
Impact of Microplastics on Human health: Time for us to get attentive- before it’s too late
This paper reviewed the growing evidence on microplastic impacts on human health, covering ingestion, inhalation, and dermal exposure routes, and the potential for microplastics to cause inflammation, oxidative stress, and endocrine disruption. The authors argue the problem demands urgent regulatory attention.
What every dentist needs to know about microplastics and dental materials.
This review examines the sources and potential health risks of microplastics originating from dental products, including toothpastes, dental composites, aligners, and other clinical materials. Researchers found that dental products can release microplastic particles during use and degradation, contributing to both patient exposure and environmental contamination. The study calls for greater awareness among dental professionals about microplastic risks and the development of safer alternative materials.
Microplastics and nanoplastics in clinical dentistry and orthodontics: leaching, health implications, and future directions: a narrative review
This narrative review examines the release of microplastics and nanoplastics from orthodontic appliances including aligners, retainers, and dental adhesives during routine wear and mechanical stress, calling for thorough investigation into health implications given the long-term use of these plastic-based devices.
Exposure and Health Effects of Microplastics in Humans
This doctoral thesis investigates exposure levels and health effects of microplastics in humans, synthesizing analytical chemistry and toxicological evidence on microplastic presence in human tissues and their potential biological impacts.
Health Implications of Microplastic Exposure in Pregnancy and Early Childhood: A Systematic Review
This systematic review summarizes existing research on how microplastic exposure during pregnancy and early childhood may affect health. The evidence shows that microplastics can reach the placenta and may cause oxidative stress and inflammation, raising concerns about potential effects on fetal development and infant health during these vulnerable life stages.