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61,005 resultsShowing papers similar to Lactiplantibacillus plantarum ZP-6 mitigates polystyrene nanoplastics-induced liver damage in colitis mice via the gut-liver axis
ClearLactobacillus plantarum reduces polystyrene microplastic induced toxicity via multiple pathways: A potentially effective and safe dietary strategy to counteract microplastic harm
Researchers found that Lactobacillus plantarum, a probiotic bacterium commonly found in fermented foods, can reduce the harmful effects of polystyrene microplastics in mice through multiple pathways. The bacteria worked by binding directly to plastic particles to help remove them from the body, reducing oxidative damage, repairing the intestinal barrier, and regulating bile acid metabolism. This suggests that certain probiotics could be a safe dietary strategy to help counteract some of the negative health effects of microplastic exposure.
Gut microbiota and liver metabolomics reveal the potential mechanism of Lactobacillus rhamnosus GG modulating the liver toxicity caused by polystyrene microplastics in mice
Researchers found that the probiotic Lactobacillus rhamnosus GG helped protect mice from liver damage caused by polystyrene microplastic exposure. The probiotic worked by restoring healthy gut bacteria and normalizing liver metabolic pathways disrupted by the microplastics. The study suggests that supporting gut health through beneficial bacteria may help mitigate some of the toxic effects microplastics have on the liver.
Lactic acid bacteria reduce polystyrene micro- and nanoplastics-induced toxicity through their bio-binding capacity and gut environment repair ability
Researchers found that lactic acid bacteria, the kind used in yogurt and fermented foods, can reduce the toxic effects of polystyrene micro and nanoplastics in mice. The bacteria worked by physically binding to the plastic particles and by repairing damage to the gut lining and restoring healthy gut bacteria populations. This suggests that probiotics could be a practical way to help protect the digestive system from the harmful effects of microplastic exposure through food and water.
Lactiplantibacillus plantarum P101 Alleviates Liver Toxicity of Combined Microplastics and Di-(2-Ethylhexyl) Phthalate via Regulating Gut Microbiota
Researchers found that the probiotic Lactiplantibacillus plantarum P101 reduced liver damage caused by combined exposure to microplastics and the plasticizer DEHP in mice. The probiotic reversed oxidative stress and inflammation in the liver and intestines while reshaping the gut microbiota. The study suggests that probiotic supplementation may offer a promising strategy for mitigating the toxic effects of co-exposure to microplastics and plastic-associated chemicals.
Could probiotics protect against human toxicity caused by polystyrene nanoplastics and microplastics?
This review examines whether probiotics could help protect against the harmful effects of polystyrene nanoplastics and microplastics in the body. Researchers found evidence that probiotic bacteria may counteract plastic-induced gut imbalances, reduce inflammation, and support intestinal barrier function. The study suggests that probiotics represent a promising area of research for mitigating some of the biological effects of microplastic exposure, though more human studies are needed.
A probiotic for preventing microplastic toxicity: Clostridium dalinum mitigates microplastic-induced damage via microbiota-metabolism-barrier interactions
Using metagenomics and metabolomics, this study found that the probiotic bacterium Clostridium dalinum reduced microplastic-induced gut damage in mice by modulating gut microbiota composition, metabolic pathways, and intestinal barrier integrity.
Polystyrene nanoplastics sequester the toxicity mitigating potential of probiotics by altering gut microbiota in grass carp (Ctenopharyngodon idella)
Researchers tested whether probiotic pretreatment could protect grass carp from the toxic effects of polystyrene nanoplastics on gut health. While probiotics initially boosted immune responses and reduced intestinal damage, the protective effect was not strong enough to fully counteract nanoplastic toxicity over time. The study suggests that nanoplastics can undermine the gut health benefits of probiotics by disrupting the balance of gut bacteria.
Gut Microbiota Participates in Polystyrene Microplastics-Induced Hepatic Injuries by Modulating the Gut–Liver Axis
This mouse study showed that polystyrene microplastics cause liver damage partly through disrupting gut bacteria, which then triggers harmful signals along the gut-liver connection. When researchers eliminated gut bacteria with antibiotics, liver damage from microplastics was reduced, confirming the gut microbiome plays a key role. Green tea extract (EGCG) helped protect the liver by restoring healthy gut bacteria, suggesting diet may help counteract some effects of microplastic exposure.
Gut dysbiosis exacerbates inflammatory liver injury induced by environmentally relevant concentrations of nanoplastics via the gut-liver axis
This mouse study found that swallowing nanoplastics at levels found in the environment disrupted gut bacteria and damaged the intestinal barrier, allowing toxins to leak into the bloodstream and cause liver inflammation. When researchers transplanted gut bacteria from nanoplastic-exposed mice into healthy mice, those mice also developed liver damage. This demonstrates that nanoplastics may harm the liver indirectly by first disrupting the gut, a finding relevant to understanding how everyday plastic exposure could affect human health.
Polystyrene nanoplastics induce intestinal and hepatic inflammation through activation of NF-κB/NLRP3 pathways and related gut-liver axis in mice
In a mouse study, ingested polystyrene nanoplastics accumulated in the gut and liver and triggered inflammation through specific immune pathways, damaging the intestinal lining and allowing bacterial toxins to leak into the liver. This gut-liver connection suggests that swallowing nanoplastics could set off a chain reaction of inflammation affecting multiple organs in the body.
The probiotic SLAB51 as agent to counteract BPA toxicity on zebrafish gut microbiota -liver-brain axis
Researchers tested whether the probiotic supplement SLAB51 could counteract the harmful effects of bisphenol A (BPA), a plastic-derived chemical, in zebrafish and found it significantly restored healthy gut bacteria, reduced liver damage, and protected the brain — suggesting probiotics may help offset harm from plastic-associated chemical exposure.
Interactions between polystyrene-derived micro- and nanoplastics and the microbiota: a systematic review of multi-omics mouse studies
Researchers systematically reviewed 15 mouse studies and found that exposure to polystyrene micro- and nanoplastics consistently disrupted gut bacteria — reducing beneficial species like Lactobacillus and increasing harmful ones — while also altering metabolic pathways throughout the body. Nanoplastics caused more severe microbiome disruption than larger microplastics, highlighting a serious health concern for humans.
Determination of the ability of native potential probiotic lactobacillus strains in nanoplastic bioremoval in an in-vitro Model
Researchers tested 88 native probiotic Lactobacillus strains for their ability to bind and remove polystyrene nanoplastics in laboratory conditions, finding that a cocktail of three strains achieved up to 77% removal. The most effective strain, L. plantarum RP13, showed strong nanoplastic adhesion confirmed by microscopy imaging. The study suggests that certain probiotic bacteria may have potential as a biological approach to reducing nanoplastic exposure in the gastrointestinal tract.
Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by Nanoplastics
Researchers engineered a probiotic-based system using modified E. coli Nissle 1917 bacteria to counteract gut barrier damage caused by nanoplastics derived from PET food packaging. The engineered probiotic was designed to produce an anti-inflammatory protein and was coated for better survival in the digestive tract, where it reduced inflammation, restored gut barrier function, and rebalanced gut bacteria in animal models. The study suggests that engineered probiotics could be a promising approach for protecting the gut from nanoplastic-related damage.
Probiotics as Modulators of Microplastic-induced Toxicity: A Systematic Review
This systematic review found that probiotics can reduce microplastic-induced toxicity in animal models by restoring gut microbiota balance, reducing oxidative stress, and modulating inflammatory responses. The findings suggest that probiotic supplementation may help mitigate the harmful effects of unavoidable microplastic exposure, though human clinical trials are still needed.
Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 suppress polystyrene nanoplastic transcellular permeability and internalization by intestinal epithelial cells
Researchers found that two yogurt starter bacteria, Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131, significantly reduced the uptake and transport of polystyrene nanoplastics by intestinal epithelial cells. The study suggests these specific strains, even when non-viable, may help limit nanoplastic accumulation in the body by suppressing their internalization in the gut lining.
Probiotics ameliorate polyethylene microplastics-induced liver injury by inhibition of oxidative stress in Nile tilapia (Oreochromis niloticus)
Researchers investigated whether probiotics could protect Nile tilapia from liver damage caused by polystyrene microplastics. The study found that fish pre-fed with probiotics showed significantly reduced oxidative stress markers in the liver compared to those exposed to microplastics alone, suggesting that probiotics may help mitigate microplastic-induced hepatic oxidative damage in fish.
Probiotics improve polystyrene microplastics-induced male reproductive toxicity in mice by alleviating inflammatory response
Researchers found that giving mice probiotics (beneficial bacteria including Lactobacillus and Bifidobacterium) helped protect against reproductive damage caused by polystyrene microplastics. The microplastics disrupted gut bacteria and triggered inflammation that traveled to the testes via the gut-testis connection, reducing sperm quality and testosterone levels. Probiotic treatment restored healthy gut bacteria and reduced the inflammatory response, suggesting that maintaining gut health could help counteract some reproductive harm from microplastic exposure.
Micro-nanoplastics inhibit extracellular polymeric substance and lactate synthesis via perturbing glucose metabolism of Lacticaseibacillus rhamnosus
Researchers found that micro- and nanoplastics — especially nanoscale PET particles — impair the probiotic bacterium Lactobacillus rhamnosus by disrupting central carbon metabolism, reducing its production of lactic acid and protective extracellular polysaccharides, raising concerns that microplastic ingestion could compromise the gut benefits of probiotic bacteria.
Polyethylene microplastics induced gut microbiota dysbiosis leading to liver injury via the TLR2/NF-κB/NLRP3 pathway in mice
Mice exposed to polyethylene microplastics developed liver damage that was traced back to disrupted gut bacteria -- the microplastics increased harmful bacteria while decreasing beneficial ones, triggering inflammation through the TLR2/NF-kB/NLRP3 immune pathway. This study provides new evidence that microplastics may harm the liver not just through direct contact, but indirectly by first throwing off the balance of gut bacteria.
Gut microbiota dysbiosis exacerbates polystyrene microplastics-induced liver inflammation via activating LPS/TLR4 signaling pathway in ducks
This study found that polystyrene microplastics exacerbate gut microbiota dysbiosis in ducks, and that this disruption of the gut microbial community amplifies liver inflammation through the gut-liver axis, revealing a mechanism by which MP exposure causes hepatic injury.
Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice
Researchers exposed mice to polystyrene microplastics for six weeks and found that the particles accumulated in the gut, reduced protective mucus secretion, and damaged the intestinal barrier. The microplastics also significantly altered the composition of gut bacteria, decreasing beneficial species and increasing harmful ones. The study suggests that microplastic ingestion could disrupt gut health in mammals by simultaneously impairing the physical barrier and reshaping the microbiome.
Novel probiotics adsorbing and excreting microplastics in vivo show potential gut health benefits
Researchers screened 784 bacterial strains and identified two probiotic strains that can stick to microplastic particles in the gut and help remove them from the body. In mice, these probiotics increased microplastic excretion by 34% and reduced the amount of plastic remaining in the intestine by 67%. This is the first study to show that specific probiotics could help the body get rid of ingested microplastics and reduce gut inflammation caused by them.
Polystyrene nanoplastics exacerbate aflatoxin B1-induced hepatic injuries by modulating the gut−liver axis
Mice exposed to both polystyrene nanoplastics and aflatoxin B1, a common food contaminant from mold, suffered worse liver damage than from either pollutant alone. The nanoplastics disrupted gut bacteria and weakened the intestinal barrier, allowing more toxins to reach the liver through the gut-liver axis. This study is concerning because it shows that microplastics can amplify the harmful effects of other food contaminants people are already exposed to.