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Determination of the ability of native potential probiotic lactobacillus strains in nanoplastic bioremoval in an in-vitro Model
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Researchers tested 88 native probiotic Lactobacillus strains for their ability to bind and remove polystyrene nanoplastics in laboratory conditions, finding that a cocktail of three strains achieved up to 77% removal. The most effective strain, L. plantarum RP13, showed strong nanoplastic adhesion confirmed by microscopy imaging. The study suggests that certain probiotic bacteria may have potential as a biological approach to reducing nanoplastic exposure in the gastrointestinal tract.
Nanoplastics (NPs) are emerging environmental pollutants that pose significant health risks, particularly due to their accumulation in the gastrointestinal tract. This study evaluates the ability of 88 native probiotic Lactobacillus strains to remove polystyrene nanoplastics (PS-NPs) in an in-vitro model. Three resistant strains L. plantarum RP13, RP134, and RP225-were selected based on disk diffusion screening. A cocktail of these strains demonstrated high percentages of NP binding: 77 % ± 2.5 at 0.1 mg/mL, 76 %± 2.1 at 0.2 mg/mL, and 67 %± 3.0 at 0.4 mg/mL. Among individual strains, RP13 exhibited the highest removal capacity. Fluorescence and electron microscopy confirmed PS-NP adhesion to bacterial surfaces. Zeta potential measurements showed a shift from -30.32 mV to -21.87 mV after bacterial exposure, indicating surface interaction. Cytotoxicity assays on HT-29 cells revealed dose-dependent toxicity of PS-NPs, which was significantly reduced by treatment with the Lactobacillus cocktail most notably at concentrations between 62.5 and 15.62 µg/mL. These promising in-vitro results suggest that our native probiotic Lactobacillus strains may offer a sustainable strategy for mitigating nanoplastic toxicity in the gastrointestinal tract; however, validation through in-vivo studies is essential to confirm their therapeutic potential and translational relevance.
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Adsorption abilities and mechanisms of Lactobacillus on various nanoplastics
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Researchers tested whether Lactobacillus, a common probiotic bacterium, could adsorb nanoplastic particles made of polypropylene, polyethylene terephthalate, and polystyrene. They found that the bacteria could efficiently bind all three types of nanoplastics through electrostatic interactions and hydrogen bonding on their cell surfaces. The study suggests that lactic acid bacteria may have potential as a biological method for reducing nanoplastic contamination in food.
Lactobacillus plantarum reduces polystyrene microplastic induced toxicity via multiple pathways: A potentially effective and safe dietary strategy to counteract microplastic harm
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Mice exposed to polystyrene microplastics were given Lactobacillus plantarum strains that differed in antioxidant activity and in how well they bind the particles. Mice given strong binders had less polystyrene in the body and more in feces. A weakly binding strain also lowered toxicity, apparently through the intestinal barrier and bile acid metabolism.
Novel probiotics adsorbing and excreting microplastics in vivo show potential gut health benefits
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Researchers screened 784 bacterial strains for the ability to bind polystyrene particles in the lab and selected two, L. paracasei DT66 and L. plantarum DT88. Mice given the strains passed 34% more polystyrene in feces and had 67% less left in the intestine. DT88 also lowered intestinal inflammation in the mice.
Lactic acid bacteria reduce polystyrene micro- and nanoplastics-induced toxicity through their bio-binding capacity and gut environment repair ability
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Mice exposed to micro- and nanoplastics were given lactic acid bacteria that differed in how strongly they bind the particles in lab tests. Stronger binders reduced toxicity more. One weak binder, Lactobacillus plantarum DT22, still lowered toxicity, by raising tight junction proteins and shifting the gut microbiota.
Lactiplantibacillus plantarum ZP-6 mitigates polystyrene nanoplastics-induced liver damage in colitis mice via the gut-liver axis
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The probiotic strain Lactiplantibacillus plantarum ZP-6 mitigated polystyrene nanoplastic-induced liver injury in an animal model through multiple mechanisms including toxin binding, barrier enhancement, and anti-inflammatory activity, suggesting probiotics as a potential strategy for reducing nanoplastic health impacts.
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