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61,005 resultsShowing papers similar to Neurosenescence, inflammaging and neuroinflammation in neurodegenerative disorders
ClearSigns of Alzheimer’s Disease: Tied to Aging
This review explores the core biological mechanisms that connect aging to Alzheimer's disease, including abnormal protein buildup, chronic brain inflammation, loss of key neurotransmitters, and blood-brain barrier dysfunction. Researchers highlight how age-related decline in the body's ability to clear waste and repair cellular damage accelerates the progression of neurodegeneration. The study underscores the need for treatments that target multiple pathways simultaneously rather than addressing a single mechanism.
Uncovering the impact of nano- and microplastics on neurodegenerative diseases and strategies to mitigate their damage
Researchers reviewed evidence that micro- and nanoplastics may contribute to the progression of Alzheimer's and Parkinson's diseases by triggering brain inflammation, disrupting mitochondria (the cell's power source), and damaging the blood-brain barrier. The review also found that natural compounds like melatonin and probiotics show early promise in reducing some of these harmful effects.
The role of microplastics exposure in Alzheimer’s and Parkinson’s disease
Researchers reviewed the mechanistic links between microplastic and nanoplastic exposure and the two most common neurodegenerative diseases — Alzheimer's and Parkinson's — finding evidence that oxidative stress, neuroinflammation, blood-brain barrier disruption, and protein aggregation are key pathways connecting plastic pollution to neurodegeneration.
Do microplastics play a role in the pathogenesis of neurodegenerative diseases? Shared pathophysiological pathways for Alzheimer’s and Parkinson’s disease
This review explores the emerging connection between microplastic exposure and neurodegenerative diseases such as Alzheimer's and Parkinson's, identifying shared pathophysiological pathways. Researchers found that microplastics can cross the blood-brain barrier and may trigger oxidative stress, neuroinflammation, and protein aggregation, which are hallmarks of these conditions. The study suggests that chronic microplastic exposure could be a contributing environmental factor in neurodegeneration, though direct causal evidence in humans is still lacking.
Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures
Researchers reviewed how environmental exposures over a lifetime — including air pollution, pesticides, heavy metals, and other toxicants — accelerate aging and raise the risk of cardiovascular disease, Alzheimer's, and Parkinson's disease, in part by crossing the blood-brain barrier and triggering inflammation. Understanding these exposome-aging links is key to developing strategies that protect brain and heart health as populations grow older.
Nano- and Microplastics in the Brain: An Emerging Threat to Neural Health
This review summarizes evidence that nano- and microplastics can cross the blood-brain barrier and accumulate in brain tissue, where they trigger oxidative stress, inflammation, and protein clumping linked to diseases like Alzheimer's and Parkinson's. The findings suggest that plastic particles may also interfere with the brain's ability to heal from injury, though long-term human studies are still lacking.
The effects of micro- and nanoplastics on the central nervous system: A new threat to humanity?
This review summarizes growing evidence that micro- and nanoplastics can cross the blood-brain barrier and damage the central nervous system through inflammation, oxidative stress, and disruption of brain chemicals. The authors note that microplastic exposure has been linked to memory and behavior changes in animals and may contribute to neurodegenerative diseases like Parkinson's, though direct human evidence is still limited.
Environmental Nanoplastic Accumulation and Neurodegenerative Disease in Animal Models
This review examines animal model evidence linking environmental nanoplastic accumulation in brain tissue to neurodegeneration, synthesizing studies showing that nanoplastics trigger neuroinflammation, protein aggregation, and synaptic dysfunction relevant to Parkinson's and Alzheimer's disease pathology.
From the Environment to Molecular Interactions of Nanoplastics: Unraveling the Neurotoxic Impacts and the Implications in Neurodegenerative Processes
This review examines how nanoplastics can cross the blood-brain barrier and potentially contribute to brain damage and neurodegenerative diseases like Alzheimer's and Parkinson's. Nanoplastics have been found in food, water, and air, and once they reach the brain they can trigger inflammation, oxidative stress, and protein misfolding. The review calls for more realistic lab studies and better detection methods to understand the true scope of nanoplastic effects on brain health.
Molecular and Cellular Effects of Microplastics and Nanoplastics: Focus on Inflammation and Senescence
This review summarizes research showing that micro- and nanoplastics trigger oxidative stress, inflammation, and premature cell aging across many experimental models. These are the same biological processes linked to heart disease, brain disorders, and other age-related conditions. Particularly concerning, studies in animals show that plastic-related damage can be passed from parents to offspring, suggesting potential long-term generational health effects.
Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases
This review explores ferroptosis, a type of iron-dependent cell death that damages brain cells through fat oxidation, and its role in neurodegenerative diseases like Alzheimer's and Parkinson's. While not directly about microplastics, ferroptosis is one of the cellular damage pathways that microplastic exposure can trigger in brain tissue. Understanding how ferroptosis works may help explain how environmental pollutants, including nanoplastics that can cross the blood-brain barrier, contribute to neurological damage.
Breaching Barriers: Microplastic Translocation into Human Body Through Food and Implications for Neurodegeneration
This systematic review traced how microplastics enter the body through food and potentially reach the brain. Once ingested, these particles can cross the gut barrier, enter the bloodstream, and accumulate in brain tissue, where they may cause oxidative stress and inflammation that could contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.
The impact of microplastics on neurodegenerative diseases and underlying molecular mechanisms: A narrative review
This review explores how microplastics that accumulate in the environment can reach the brain through inhalation or by crossing the blood-brain barrier. Researchers examined evidence suggesting that microplastics may contribute to the onset or acceleration of neurodegenerative conditions by triggering harmful responses in brain cells. The study calls for stronger environmental policies, better detection methods, and further research into potential therapeutic interventions.
Nanoplastics: An emerging environmental concern in age-related diseases
This review examines the growing body of evidence linking nanoplastics to aging and age-related conditions. Researchers found that nanoplastics can disrupt key molecular pathways involved in inflammation, oxidative stress, and cellular damage that are central to the aging process. The study suggests that chronic nanoplastic exposure may accelerate biological aging, raising concerns about long-term health effects as environmental plastic pollution continues to increase.
Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease
Researchers reviewed natural bioactive compounds from plant sources for their potential neuroprotective effects related to Alzheimer's disease. The study highlights how these compounds may modulate molecular mechanisms involved in disease development, while noting challenges such as limited bioavailability and blood-brain barrier permeability.
Alzheimer’s disease: the role of extrinsic factors in its development, an investigation of the environmental enigma
This review examines how environmental contaminants, including microplastics, may contribute to Alzheimer's disease risk. Along with air pollutants, toxic metals, and pesticides, plastics and microplastics are identified as potential risk factors that may promote brain inflammation and neurodegeneration. The review explores the molecular mechanisms behind these effects and suggests strategies to reduce the brain health impacts of environmental contaminants.
Insights into the toxic effects of micro-nano-plastics on the human brain and their relationship with the onset of neurological diseases: A narrative review.
This review examined toxic effects of micro and nano-plastics (MNPs) on the human brain, linking MNP exposure to neuroinflammation, oxidative stress, disruption of the blood-brain barrier, and progression toward neurodegenerative diseases. The authors synthesized evidence from cell studies, animal models, and emerging human data.
Elucidating the Neurotoxicopathological Impact of Micro and Nanoplastics: Mechanistic Insights Into Oxidative Stress-mediated Neurodegeneration and Implications for Public Health in a Plastic Pervasive Era
Researchers reviewed the growing evidence linking micro- and nanoplastic exposure to neurodegenerative diseases, identifying oxidative stress, neuroinflammation, DNA damage, and protein misfolding as key mechanisms of harm to the brain. The review highlights critical knowledge gaps — especially around chronic low-dose exposure — and calls for better detection tools and public health policies to address the emerging neurological threat from plastic pollution.
Mechanistic insight of neurodegeneration due to micro/nano-plastic-induced gut dysbiosis.
This review provided mechanistic insight into how micro/nano-plastic-induced gut dysbiosis drives neurodegeneration, tracing a pathway from intestinal microbiome disruption to neuroinflammation and brain damage. It identified the gut-brain axis as the critical link between plastic particle exposure and progressive neurodegenerative conditions.
Advances in research on the pathogenesis and signaling pathways associated with postoperative delirium (Review)
This review examines the causes and biological pathways behind postoperative delirium, a common complication especially in older patients, involving neuroinflammation, oxidative stress, and gut-brain signaling. While not focused on microplastics, several pathways discussed, such as neuroinflammation and the gut-brain axis, overlap with mechanisms through which microplastics may affect brain health. Understanding these pathways helps explain how environmental pollutants could contribute to cognitive problems.
From exposure to neurotoxicity induced by micro-nanoplastics with brain accumulation and cognitive decline
This review synthesizes evidence that micro- and nanoplastics can reach the brain by crossing the blood-brain barrier or traveling along nerve pathways, accumulating in regions critical for memory and thinking. Animal studies show that chronic exposure leads to cognitive problems, behavioral changes, and brain changes resembling neurodegenerative diseases, driven by oxidative stress, inflammation, and disruption of the gut-brain connection. The findings raise concern that long-term human exposure to nanoplastics through food and air could contribute to cognitive decline and neurological disease.
The Role of Emerging Environmental Contaminants on Alzheimer’s Disease
This review examined the role of emerging environmental contaminants, including microplastics, in the development and progression of Alzheimer's disease. The authors discussed mechanisms including oxidative stress, neuroinflammation, and blood-brain barrier disruption as potential pathways linking environmental exposures to AD pathogenesis.
Neurotoxicities induced by micro/nanoplastics: A review focusing on the risks of neurological diseases
This review summarizes evidence that micro- and nanoplastics can reach the brain through the bloodstream and nerve pathways, where they trigger oxidative stress, inflammation, and cell damage that may contribute to neurodegenerative diseases. The particles are found in air, water, soil, and food, meaning humans are constantly exposed through breathing, eating, and skin contact, making brain effects a serious long-term concern.
Deciphering the Neurotoxic Burden of Micro- and Nanoplastics: From Multi-model Experimental Evidence to Therapeutic Innovation
This review summarizes research on how micro- and nanoplastics damage the brain and nervous system, covering evidence from cell studies, animal experiments, and clinical observations. Plastic particles can cross the blood-brain barrier, disrupt the gut-brain connection, cause oxidative stress, and trigger inflammation that leads to memory problems and cognitive decline. The review also discusses potential treatment strategies, making it a useful resource for understanding the brain health risks of plastic exposure.