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61,005 resultsShowing papers similar to Assessment of Nanoplastic-Induced Disruption in CellularGlutathione Metabolism Using a Bubble-Assisted Photothermal CaptureSERS Sensor
ClearAssessment of Nanoplastic-Induced Disruption in CellularGlutathione Metabolism Using a Bubble-Assisted Photothermal CaptureSERS Sensor
This study assessed how nanoplastics and aged nanoplastics disrupt cellular glutathione metabolism, developing a new analytical method to simultaneously measure glutathione and glutathione disulfide and finding that NP exposure impairs antioxidant defense in exposed cells.
Assessment of Nanoplastic-Induced Disruption in Cellular Glutathione Metabolism Using a Bubble-Assisted Photothermal Capture SERS Sensor
Researchers developed a novel sensor using bubble-assisted photothermal capture and SERS technology to measure how nanoplastics disrupt cellular glutathione metabolism, a key indicator of oxidative stress. They found that nanoplastic exposure depleted total glutathione levels and reduced the GSH/GSSG ratio in a dose-dependent manner, with environmentally aged nanoplastics causing more pronounced oxidative damage than pristine ones. The study provides a rapid method for assessing nanoplastic toxicity and suggests that environmental aging increases the health risks of nanoplastic exposure.
Machine Learning-Aided 3D Dynamic SERS Strategy for Physiological Mapping: Biotoxicity of Environmentally Dimensional Aged Nanoplastics and Corresponding Protein Corona Complexes
Researchers used a new combination of 3D surface-enhanced Raman spectroscopy and machine learning to study the toxicity of nanoplastics on cells. They found that aged nanoplastics and those coated with proteins from the environment caused different types of cell damage depending on the plastic type. This approach could help scientists more rapidly assess the biological hazards of nanoplastics found in the environment.
Is microplastic an oxidative stressor? Evidence from a meta-analysis on bivalves
Microplastics induce time-dependent oxidative stress in bivalves, with antioxidant enzymes (GPx, GST, SOD) increasing during short-term exposure but declining after long-term exposure, while glutathione levels and catalase activity remained elevated throughout and may serve as reliable biomarkers of sublethal microplastic effects.
In situ surface-enhanced Raman spectroscopy for the detection of nanoplastics: A novel approach inspired by the aging of nanoplastics
Researchers developed a novel in-situ SERS (surface-enhanced Raman scattering) detection method for nanoplastics that exploits UV photoaging to generate silver nanoparticles directly on particle surfaces, enabling highly sensitive identification of polystyrene, PVC, and PET nanoplastics in real lake water samples at concentrations as low as 1 × 10⁻⁶ mg/mL.
Cell Responseto Nanoplastics and Their Carrier EffectsTracked Real-Timely with Machine Learning-Driven Smart Surface-EnhancedRaman Spectroscopy Slides
Researchers developed smart SERS slides to monitor in real-time how cells respond to polystyrene nanoplastics and their ability to carry contaminants (the 'carrier effect'). The platform captured intracellular metabolic changes at the molecular level, showing nanoplastics extended cell cycle S and G2 phases in lung cells and that carried pollutants caused additional distinct cellular effects.
Nanoplastics in biological systems: What laboratory mechanisms reveal about real-world toxicity
Researchers developed a mechanistic-scaling framework reconciling high-dose laboratory toxicity data for nanoplastics with low-dose environmental realities, arguing that core injury pathways—oxidative stress, lysosomal rupture, mitochondrial dysfunction—remain active at environmental concentrations and are amplified by particle aging and co-contaminant loading.
Toxicity Induced by Micro-and Nanoplastics through Oxidative Stress: The Role of Co-Exposure to Other Chemical Pollutants
This review examined how micro- and nanoplastics cause oxidative stress — a form of cellular damage — in living organisms, particularly when combined with other chemical pollutants in the environment. Co-exposure to microplastics and chemicals like pesticides or heavy metals tends to be more damaging than either pollutant alone.
Probing the molecular mechanism of interaction between polystyrene nanoplastics and catalase by multispectroscopic techniques
Researchers investigated the molecular mechanism of interaction between polystyrene nanoplastics and the antioxidant enzyme catalase using multispectroscopic techniques, revealing how nanoplastic accumulation may disrupt enzymatic function and contribute to oxidative stress.
Size-dependent effects of nanoplastics on structure and function of superoxide dismutase
Researchers used multi-spectroscopic techniques to examine how nanoplastics of different sizes interact with and alter the structure and function of the antioxidant enzyme superoxide dismutase. The study found size-dependent effects, with nanoplastics binding to the enzyme and altering its secondary structure, ultimately reducing its activity, which has implications for understanding how nanoplastics may disrupt cellular antioxidant defenses.
Characterizing nanoplastics‐induced stress and its SERS fingerprint in an intestinal membrane model
Researchers used SERS (surface-enhanced Raman scattering) to detect nanoplastic-induced stress in a Caco-2 intestinal epithelial membrane model, finding that amine-functionalized polystyrene nanoparticles disrupted barrier function and produced distinct spectral fingerprints in the extracellular medium, demonstrating a non-invasive method for monitoring nanoplastic cellular stress.
Photoaged polystyrene nanoplastics induce perturbation of glucose metabolism in HepG2 cells via oxidative stress
Researchers exposed human liver cells to polystyrene nanoplastics with varying degrees of UV-induced aging and found that photoaged particles caused more severe disruptions to glucose metabolism than pristine ones. Long-term photoaged nanoplastics triggered dose-dependent metabolic disorders through oxidative stress, while pristine particles only caused effects at high concentrations. The study suggests that weathered nanoplastics in the environment may pose greater health risks than fresh plastic particles.
Molecular toxicity of nanoplastics involving in oxidative stress and desoxyribonucleic acid damage
This review examines the molecular mechanisms by which nanoplastics induce oxidative stress and DNA damage in biological systems, synthesizing findings from cell culture and animal studies. The evidence suggests that nanoplastics can cause genotoxic effects at the cellular level, which is relevant to understanding potential long-term health risks of chronic nanoplastic exposure.
Nanoparticle-Biological Interactions in a Marine Benthic Foraminifer
Researchers exposed single-celled marine organisms called foraminifera to three types of engineered nanoparticles — including polystyrene nanoplastics — and found that all three accumulated inside the cells and triggered oxidative stress (a form of cellular damage). This study shows that even microscopic seafloor organisms are vulnerable to nanoplastic pollution, expanding the known range of species harmed by plastic contamination.
Mechanisms of Cell Toxicity Caused by Degraded Microplastics
This review examined the molecular and cellular mechanisms by which degraded microplastics cause toxicity, focusing on how physical and chemical changes during environmental weathering alter plastic particle biological activity. The paper discussed oxidative stress, membrane disruption, and inflammatory pathways as key toxicity mechanisms of degraded microplastic fragments.
Nanoelectrochemistry monitoring of intracellular reactive oxygen and nitrogen species induced by nanoplastic exposure
Researchers used tiny nanoelectrodes to measure reactive oxygen and nitrogen species inside lung cells exposed to nanoplastics. They found that nanoplastic exposure significantly increased nitrogen-based reactive species while oxygen-based species remained relatively stable. The study provides new evidence about the specific types of oxidative stress that airborne nanoplastics can trigger inside human cells.
Effects of micro/nanoplastics on oxidative damage and serum biochemical parameters in rats and mice: a meta-analysis
A meta-analysis of 36 studies in rats and mice found that micro/nanoplastics significantly increase oxidative stress markers (ROS, MDA) and liver enzymes (ALT, AST) while depleting antioxidant defenses (SOD, GSH, GPx, CAT). Smaller particles administered orally over longer durations caused the most pronounced damage, with the liver showing the highest elevations in biochemical stress markers.
Stress Response of Mouse Embryonic Fibroblasts Exposed to Polystyrene Nanoplastics
Mouse embryonic fibroblasts exposed to polystyrene nanoplastics internalized particles via endocytosis without losing viability, but showed activation of antioxidant and autophagic stress pathways, suggesting subcellular dysfunction even in the absence of cell death.
Nanoplastics: An emerging environmental concern in age-related diseases
This review examines the growing body of evidence linking nanoplastics to aging and age-related conditions. Researchers found that nanoplastics can disrupt key molecular pathways involved in inflammation, oxidative stress, and cellular damage that are central to the aging process. The study suggests that chronic nanoplastic exposure may accelerate biological aging, raising concerns about long-term health effects as environmental plastic pollution continues to increase.
Nanoplastics in aquatic environments: The hidden impact of aging on fate and toxicity
This review highlights that most toxicity studies on nanoplastics use brand-new pristine particles, but real-world nanoplastics are aged by sunlight and chemical exposure, which fundamentally changes their surface properties and toxicity. Aged nanoplastics may be more harmful than pristine ones because they interact differently with biological systems, meaning current safety assessments likely underestimate the true risks.
Impact of Degradation of Polyethylene Particles on Their Cytotoxicity
Researchers found that degradation of polyethylene particles altered their cytotoxicity, with weathered and fragmented PE showing different toxic effects on cells compared to pristine particles, suggesting environmental aging changes microplastic health risks.
Weathered polyethylene microplastics exposure leads to modulations in glutathione-S-transferase activity in fish
Researchers reported that exposure to weathered polyethylene microplastics modulates glutathione-S-transferase activity in fish, indicating that environmentally aged microplastics can trigger oxidative stress responses in marine organisms.
Real-time quantification of nanoplastics-induced oxidative stress in stretching alveolar cells
This study developed a real-time method to quantify oxidative stress in lung cells induced by nanoplastics under conditions simulating breathing mechanics, addressing the gap in understanding how inhaled nanoplastics affect cells dynamically. The approach revealed how nanoplastics entering via air pollutants trigger intracellular oxidative damage in alveolar cells.
Environmental Microplastics Exposure and Its Biochemical Impacts on Human Oxidative Stress Markers: A Clinical Chemistry Perspective
This clinical chemistry review examined how environmental microplastic exposure affects oxidative stress markers in humans, synthesizing evidence on circulating reactive oxygen species, antioxidant enzyme changes, and inflammatory biomarkers. The authors found consistent evidence that MNP exposure elevates markers of oxidative damage across multiple tissue types.