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Nanoelectrochemistry monitoring of intracellular reactive oxygen and nitrogen species induced by nanoplastic exposure
Summary
Researchers used tiny nanoelectrodes to measure reactive oxygen and nitrogen species inside lung cells exposed to nanoplastics. They found that nanoplastic exposure significantly increased nitrogen-based reactive species while oxygen-based species remained relatively stable. The study provides new evidence about the specific types of oxidative stress that airborne nanoplastics can trigger inside human cells.
Airborne nanoplastics can enter alveolar cells and trigger intracellular oxidative stress primarily. Herein, taking advantage of the high electrochemical resolution of SiC@Pt nanoelectrodes, we achieved the quantitative discrimination of the major ROS/RNS within A549 cells, disclosed the sources of their precursors, and observed that the NO (RNS precursor) level significantly increased, whereas O2˙- (ROS precursor) remained relatively stable during the nanoplastics exposure. This establishes that iNOS or mitochondrion-targeted treatment may be a preventive or therapeutic strategy for nanoplastic-induced lung injury.
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