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61,005 resultsShowing papers similar to Biological effects of polystyrene micro- and nano-plastics on human intestinal organoid-derived epithelial tissue models without and with M cells.
ClearThe effects of polystyrene microplastics on human intestinal cells health and function
This study examined how polystyrene microplastics affect normal and cancer intestinal cells, addressing a gap left by previous research that used only cancer cell lines and pristine plastics. The work evaluated microplastic toxicity under more realistic conditions including digestive system biotransformation, assessing effects on nutrient uptake and cellular function.
Multi-endpoint toxicological assessment of polystyrene nano- and microparticles in different biological models in vitro
Researchers assessed the toxicity and transport of polystyrene nano- and microparticles using multiple human cell models, including intestinal and placental barrier systems. They found that while neither size was acutely toxic, the nanoparticles were able to cross the intestinal barrier and showed some embryotoxic potential. The study suggests that nanoplastics may pose greater health concerns than microplastics due to their ability to penetrate biological barriers.
Interactions of polystyrene nanoplastics with in vitro models of the human intestinal barrier
Researchers assessed the effects of polystyrene nanoparticles on two in vitro models simulating the human intestinal barrier and its associated immune system. The study found that while cell viability and membrane integrity were largely maintained, the nanoparticles were able to interact with and translocate across the intestinal cell layers, raising questions about potential long-term exposure effects.
Elucidating the Size‐Dependency of In Vitro Digested Polystyrene Microplastics on Human Intestinal Cells Health and Function
Polystyrene microplastics of different sizes were subjected to simulated in vitro digestion and then applied to human intestinal cells, with smaller particles causing greater disruption to cell health and barrier function than larger ones. The results suggest that the smallest microplastics reaching the human gut pose the greatest risk to intestinal integrity.
Mechanisms of ingested polystyrene micro-nanoplastics (MNPs) uptake and translocation in an in vitro tri-culture small intestinal epithelium
Researchers used a sophisticated laboratory model of the human small intestine to study how micro- and nanoplastics cross the gut barrier after simulated digestion. They found that smaller nanoplastics were absorbed more efficiently than larger microplastics, and the particles used multiple cellular pathways to cross the intestinal lining. The study provides new evidence about the mechanisms by which ingested plastic particles could potentially reach the bloodstream.
An inverted in vitro triple culture model of the healthy and inflamed intestine: Adverse effects of polyethylene particles.
Using a laboratory model of the human intestinal lining, researchers tested how polyethylene microplastics affect intestinal cells and found they disrupted the barrier function of the gut wall. A compromised intestinal barrier allows larger molecules and particles to pass into the body, which could amplify the health effects of microplastic ingestion.
Distinct accumulation of nanoplastics in human intestinal organoids
Researchers exposed human intestinal organoids to polystyrene nanoplastics and found that these tiny particles accumulated in distinct patterns within the gut tissue model. The study observed that nanoplastic uptake increased with concentration and caused measurable changes in the intestinal cells. These findings provide early evidence that nanoplastics can be absorbed by human intestinal tissue, raising questions about potential long-term health effects from dietary exposure.
Effects of bisphenol A and nanoscale and microscale polystyrene plastic exposure on particle uptake and toxicity in human Caco-2 cells
Researchers studied how human intestinal Caco-2 cells take up polystyrene plastic particles of five different sizes ranging from 300 nanometers to 6 micrometers. The study found that smaller particles were taken up at higher rates and that co-exposure with bisphenol A increased cellular toxicity, suggesting that nanoscale plastics may pose a greater risk to human intestinal cells than larger microplastics.
The Role of the Size and Surface Chemistry of Polystyrene Micro- and Nanobeads in the Interaction with an Advanced In Vitro Tri-Culture Intestinal Barrier Model
Researchers studied how the size and surface chemistry of polystyrene micro- and nanobeads affect their interaction with an advanced three-cell-type intestinal barrier model. The study examined how particle characteristics influence uptake, barrier integrity, and inflammatory responses in the gut lining. The findings suggest that both size and surface modifications play important roles in determining how plastic particles interact with intestinal tissue.
The potential effects of microplastic pollution on human digestive tract cells
Researchers tested polystyrene particles of four different sizes on human colon and small intestine cells to assess the potential effects of microplastic ingestion. They found that the smallest nanoscale particles were more readily taken up by cells and caused greater reductions in cell viability and increased oxidative stress. The study suggests that smaller plastic particles may pose a greater risk to the human digestive tract than larger ones.
Cytotoxicity of UV-degradated polystyrene nanoplastics in co-culture model of inflammatory bowel disease.
Researchers exposed intestinal co-culture models representing inflammatory bowel disease to UV-degraded polystyrene nanoplastics, finding greater cytotoxicity compared to pristine particles. The results suggest that people with IBD may be more vulnerable to nanoplastic-induced gut damage than healthy individuals.
Mapping the impact of microplastics exposure on enteric viral infections in intestinal organoid models
Researchers mapped the impact of microplastic and nanoplastic exposure on enteric viral infections in intestinal epithelial cells, finding that MNP exposure altered cell surface receptors and tight junctions in ways that may increase susceptibility to viral entry and intestinal infection.
Investigations of acute effects of polystyrene and polyvinyl chloride micro- and nanoplastics in an advanced in vitro triple culture model of the healthy and inflamed intestine
Researchers tested the acute toxicity of polystyrene and polyvinyl chloride micro- and nanoparticles using an advanced triple-culture model of the human intestinal barrier, including both healthy and inflamed conditions. They found that the plastic particles did not cause significant acute toxicity at the concentrations tested, though the inflamed intestinal model showed greater particle uptake. The study suggests that while short-term exposure may not cause immediate damage, chronic exposure and pre-existing inflammation could influence how the body handles ingested microplastics.
Biological effects of Micro and Nanoplastics from environmentally relevant sources on an in vitro model of the intestinal barrier
This thesis investigated human exposure levels and genotoxic and toxic effects of micro- and nanoplastics from environmentally relevant sources on an in vitro intestinal barrier model, aiming to provide risk-relevant data to regulatory agencies about MNPs as persistent contaminants.
DistinctEffects between Polystyrene Micro- and Nanoplastics:Exacerbation of Adverse Outcomes in Inflammatory Bowel Disease-likeZebrafish and Mice
Researchers compared the effects of polystyrene micro- and nanoplastics on a biological system, finding that nanoplastics caused more severe adverse effects than microplastics at equivalent mass doses, likely due to greater surface area and cellular penetration capacity.
Impact of Micro‐ and Nano‐Plastics on Human Intestinal Organoid‐Derived Epithelium
Researchers developed a detailed protocol for testing how micro and nanoplastics affect the human intestinal lining using patient-derived intestinal organoids, which are lab-grown miniature gut tissues that closely mimic real human intestines. The model includes specialized M cells that are key to how particles cross the gut barrier, making it more realistic than standard cell line experiments. This advanced testing approach will help scientists better understand how microplastics we swallow through food and water interact with and potentially damage the human digestive system.
Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo
Researchers studied the uptake and effects of orally ingested polystyrene microplastic particles using human intestinal cell models and rodent experiments. They found that smaller microplastics were taken up by intestinal cells and could cross the gut barrier, though the majority passed through the digestive system. The study suggests that while most ingested microplastics are excreted, a fraction can be absorbed, warranting further investigation into long-term health effects.
Nanoplastics as a potential environmental health factor: effects of polystyrene nanoparticles on human intestinal epithelial Caco-2 cells
Researchers tested how polystyrene nanoparticles interact with human intestinal cells in the lab. They found that the nanoparticles were readily taken up by the cells in a concentration-dependent manner, but no significant toxic effects were observed under the conditions tested. The study suggests that while nanoplastics can enter gut cells, their short-term toxicity at the tested levels appears limited.
Nano-plastics and gastric health: Decoding the cytotoxic mechanisms of polystyrene nano-plastics size
Researchers examined how different sizes of polystyrene nanoplastics affect human stomach cells in the laboratory. They found that smaller nanoplastics were more readily taken up by the cells and caused greater damage, including increased oxidative stress and reduced cell survival. The study suggests that nanoplastic particle size plays a critical role in determining their potential impact on gastrointestinal health.
An innovative in vitro model of IBD to assess micro-/nano-plastics intestinal toxicity.
Researchers developed an innovative in vitro intestinal inflammation model (IBD model) to assess the toxicity of micro- and nanoplastics at realistic concentrations and polymer types, moving beyond the high-dose polystyrene-only studies that dominate current literature.
Exposure of Polystyrene Nano- and Microplastics in Increasingly Complex In Vitro Intestinal Cell Models
Researchers tested polystyrene nano- and microplastics across increasingly realistic models of the human intestine and found that only the smallest particles (50 nm) could cross the intestinal barrier. A mucus layer -- like the one in real human guts -- significantly reduced particle crossing, which is reassuring but highlights the need for more research on long-term, real-world exposure levels.
Comparative evaluation of molecular mechanisms triggered by differently functionalized polystyrene nanoplastics in human colon cell lines
Researchers compared the molecular mechanisms triggered by polystyrene nanoplastics with different surface functionalization in human colon cell lines. The study examined how surface chemistry of nanoplastic particles influences their biological interactions with intestinal cells, contributing to understanding of how nanoplastics may affect the human gastrointestinal system.
Advanced epithelial lung and gut barrier models demonstrate passage of microplastic particles
Researchers tested microplastics of various sizes, shapes, and materials on advanced lab models of human lung and gut tissue, finding that several types — including polystyrene spheres and nylon fibers — physically crossed the tissue barrier, disrupted its integrity, and triggered inflammation, providing direct evidence that microplastics can penetrate our body's defenses.
A novel 3D intestine barrier model to study the immune response upon exposure to microplastics
Scientists developed a three-dimensional in vitro intestinal model using human epithelial cell lines (Caco-2 and HT-29) to study the immune response to ingested microplastics, finding that microplastics induced inflammatory cytokine release and altered barrier integrity in a dose-dependent manner.