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61,005 resultsShowing papers similar to Effect of microplastics and nanoplastics in gastrointestinal tract on gut health: A systematic review.
ClearEffect of microplastics and nanoplastics in gastrointestinal tract on gut health: A systematic review.
This systematic review provides the first comprehensive look at how microplastics and nanoplastics affect the human gut using laboratory models. The findings help explain how these tiny particles may damage the digestive tract lining and trigger inflammation, which is important for understanding the health risks of swallowing microplastics in food and water.
Impact of micro- and nanoplastics on gastrointestinal diseases: Recent advances
This review summarizes how micro- and nanoplastics can harm the digestive system by causing oxidative stress, inflammation, cell death, and disruption of gut bacteria. These connected pathways can damage the intestinal lining and may contribute to conditions like inflammatory bowel disease and colorectal cancer. The findings highlight the importance of understanding how everyday plastic exposure through food and water could affect gut health over time.
Micro(nano)plastics and Their Potential Impact on Human Gut Health: A Narrative Review
This review summarizes research on how micro- and nanoplastics affect the gut, finding that they can damage the intestinal lining, trigger immune responses, and disrupt the balance of beneficial gut bacteria in both cell studies and animal models. Since humans are primarily exposed to microplastics through food and food packaging, understanding these gut effects is essential for assessing the true health risks of plastic pollution.
The potential effects of microplastic pollution on human digestive tract cells
Researchers tested polystyrene particles of four different sizes on human colon and small intestine cells to assess the potential effects of microplastic ingestion. They found that the smallest nanoscale particles were more readily taken up by cells and caused greater reductions in cell viability and increased oxidative stress. The study suggests that smaller plastic particles may pose a greater risk to the human digestive tract than larger ones.
Nano-plastics and gastric health: Decoding the cytotoxic mechanisms of polystyrene nano-plastics size
Researchers examined how different sizes of polystyrene nanoplastics affect human stomach cells in the laboratory. They found that smaller nanoplastics were more readily taken up by the cells and caused greater damage, including increased oxidative stress and reduced cell survival. The study suggests that nanoplastic particle size plays a critical role in determining their potential impact on gastrointestinal health.
A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells
Researchers conducted a systematic review and statistical analysis of studies examining the effects of microplastic exposure on human cells in the laboratory. They found evidence that microplastics can cause cell damage, inflammation, and oxidative stress, with smaller particles and higher doses generally producing stronger effects. The study provides the first pooled estimate of dose-response thresholds for microplastic toxicity in human cells, helping to frame the potential health risks of daily exposure.
Micro(nano)plastics and their potential impact on human gut health: a narrative review
This narrative review synthesizes evidence on how microplastics and nanoplastics affect the human gut, discussing ingestion routes, gut barrier interactions, microbiome disruption, and potential systemic health effects.
Recent Progress in Intestinal Toxicity of Microplastics and Nanoplastics: Systematic Review of Preclinical Evidence
This systematic review of animal studies from 2021 to 2024 found growing evidence that swallowed microplastics and nanoplastics can damage the gut. Effects include inflammation, weakened gut barriers, oxidative stress, and disrupted gut bacteria. These findings suggest that the plastic particles found in our food could pose a risk to digestive health, though more research with realistic exposure levels is needed.
Mechanisms of microplastics on gastrointestinal injury and liver metabolism disorder (Review)
This review summarizes how microplastics and nanoplastics can damage the gastrointestinal tract and disrupt liver metabolism when they enter the human body. The particles trigger oxidative stress, inflammation, and cell death in gut tissues, and can interfere with how the liver processes glucose and fats. As plastics continue to break down into ever-smaller particles, the potential for harm increases because nanoplastics can penetrate cells more easily.
The detrimental effects of micro-and nano-plastics on digestive system: An overview of oxidative stress-related adverse outcome pathway
This review maps out how micro and nanoplastics damage the digestive system, identifying oxidative stress as the initial trigger that leads to inflammation, cell death, disrupted gut bacteria, and metabolic disorders. The authors use an adverse outcome pathway framework to connect molecular-level damage to broader health consequences. The findings suggest that ongoing microplastic exposure through food and water could contribute to digestive health problems.
The infiltration of microplastics in human systems: Gastrointestinal accumulation and pathogenic impacts
This review focuses on how microplastics accumulate in the human digestive system and what health problems they might cause. The authors explain that people ingest microplastics through food, water, and air, and these particles may trigger inflammation, disrupt gut bacteria, and potentially contribute to gastrointestinal diseases.
Microplastics and Nanoplastics in Health Concerning Cellular Toxicity Mechanisms, Exposure Pathways, and Global Mitigation Strategies
This review synthesizes current knowledge on how micro- and nanoplastics cause cellular damage in the human body, covering mechanisms like oxidative stress, inflammation, DNA damage, and disruption of cell signaling pathways. Researchers note that exposure occurs through multiple routes including ingestion and inhalation, allowing particles to reach organs throughout the body. The study highlights significant gaps in understanding long-term and low-dose exposure effects that are most relevant to everyday human contact with these particles.
[Effect of microand nanoplastics on the gastrointestinal mucosa and intestinal microbiome].
This review examines how micro- and nanoplastics entering through the food chain affect the gastrointestinal tract, finding evidence of disruption to gut mucosal integrity and intestinal microbiome composition, with implications for digestive health and systemic immune function.
Micro/nanoplastics and human health: A review of the evidence, consequences, and toxicity assessment
This review summarizes evidence that micro and nanoplastics have been found in multiple human organs and body fluids, where they can alter cell shape, damage mitochondria, reduce cell survival, and cause oxidative stress. The health effects depend heavily on the size, shape, and chemical makeup of the particles, with smaller nanoplastics generally posing the greatest risk because they penetrate deeper into tissues. The review provides a framework for assessing how dangerous different types of plastic particles are to human health.
Micro(nano)plastics in food system: potential health impacts on human intestinal system.
This review assessed how micro(nano)plastics in the human food system reach the intestine and accumulate in the gut, summarizing evidence that they can alter intestinal barrier function, trigger inflammation, and disrupt the gut microbiome, with implications for long-term digestive health.
Elucidating the Size‐Dependency of In Vitro Digested Polystyrene Microplastics on Human Intestinal Cells Health and Function
Polystyrene microplastics of different sizes were subjected to simulated in vitro digestion and then applied to human intestinal cells, with smaller particles causing greater disruption to cell health and barrier function than larger ones. The results suggest that the smallest microplastics reaching the human gut pose the greatest risk to intestinal integrity.
A critical review of microplastics toxicity and potential adverse outcome pathway in human gastrointestinal tract following oral exposure
This review uses an adverse outcome pathway framework to systematically evaluate how microplastics may cause harm in the human digestive system after being swallowed. The analysis found that while microplastics trigger recognized biological stress responses like cell death and inflammation, there are still major gaps in understanding exactly how they initiate damage at the molecular level. The authors emphasize that we need better data on both external exposure from food and water and internal exposure from particles crossing the gut lining to properly assess the health risks.
Are Microplastics Toxic? A Review from Eco-Toxicity to Effects on the Gut Microbiota
This review summarizes existing research on the toxicity of micro- and nanoplastics, from environmental organisms to effects on gut bacteria. Studies show these particles can cause oxidative stress, disrupt energy metabolism, and damage genes in a range of species. With micro- and nanoplastics now found in human blood, lung tissue, and placentas, the authors stress that much more research is needed to understand the full health risks to people.
Assessing the Impact of Nanoplastics in Biological Systems: Systematic Review of In Vitro Animal Studies
This systematic review of lab studies found that nanoplastics can damage cells in the gut, lungs, liver, brain, and reproductive organs of animals. These ultra-small plastic particles appear capable of crossing biological barriers and causing inflammation and oxidative stress, raising concerns about similar effects in humans.
A review on microplastics and nanoplastics in the environment: Their occurrence, exposure routes, toxic studies, and potential effects on human health
This review summarizes what is known about how microplastics and nanoplastics enter the human body through food, air, and skin contact, and what they do once inside. Studies on cells and animals show these tiny particles can cause oxidative stress, DNA damage, inflammation, and harm to the immune, digestive, reproductive, and nervous systems. The research makes clear that microplastics are not just an environmental problem but a direct concern for human health.
Exposure to Polypropylene Microplastics via Oral Ingestion Induces Colonic Apoptosis and Intestinal Barrier Damage through Oxidative Stress and Inflammation in Mice
Researchers gave mice polypropylene microplastics (smaller than 10 micrometers) by mouth for 28 days and found significant damage to the colon, including inflammation, destruction of the gut barrier, and increased cell death. The smaller particles caused more severe damage than larger ones, triggering an inflammatory pathway that broke down the protective lining of the intestine. This is one of the first studies on polypropylene, the most common plastic found in human tissue, showing it can damage the gut at sizes small enough to be absorbed by the body.
Microplastics and health hazards: gastrointestinal risk assessment across a multi-species perspective
This review assesses the gastrointestinal health risks of micro- and nanoplastics across multiple species, from aquatic organisms to mammals, examining how these particles interact with the digestive system. Researchers found that microplastics can cause gut inflammation, alter the microbiome, and potentially cross the intestinal barrier into other tissues. The study highlights that understanding effects across species can help predict potential risks to human digestive health.
Cellular and Systemic Effects of Micro- and Nanoplastics in Mammals—What We Know So Far
This review summarized known cellular and systemic effects of micro- and nanoplastics in mammals, finding that while ingestion is common, knowledge of health impacts remains limited, with oxidative stress and inflammation as the most reported biological responses.
Quantifying the influence of micro and nanoplastics characteristics on cytotoxicity in caco-2 cells through machine learning modelling.
This systematic review uses machine learning to identify which characteristics of micro and nanoplastics are most toxic to intestinal cells. The researchers found that particle size, shape, and concentration all play important roles in how much damage these plastics cause to gut lining cells, helping us understand how ingested microplastics might affect digestive health.