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61,005 resultsShowing papers similar to Maternal polystyrene nanoplastics suppress zebrafish offspring development and locomotion through mitochondrial dysfunction
ClearFrom mothers to offspring: Polystyrene nanoplastics create a hidden toxic legacy via mitochondrial dysfunction
Researchers exposed female zebrafish to polystyrene nanoplastics before mating with unexposed males and found that maternal exposure at 100 μg/L reduced offspring hatching success and caused developmental defects in the F1 generation raised in clean water, demonstrating transgenerational toxicity via mitochondrial dysfunction.
Maternal transfer of nanoplastics to offspring in zebrafish (Danio rerio): A case study with nanopolystyrene
Researchers demonstrated maternal transfer of polystyrene nanoplastics in zebrafish by feeding exposed females and detecting particles in yolk sacs, livers, and guts of offspring, finding that transferred nanoplastics reduced antioxidant enzyme activity and caused bradycardia in embryos without major effects on overall reproductive success.
Adverse adult-onset and multigenerational effects in zebrafish (Danio rerio) developmentally exposed to polystyrene nanoplastics
Researchers raised zebrafish exposed to nanoplastics during early development through to adulthood and found lasting reproductive impairment, heritable hyperactivity in offspring, and molecular changes in male reproductive and brain tissue linked to neurodegenerative disease pathways and endocrine disruption, demonstrating that brief developmental nanoplastic exposure can cause multigenerational harm.
Behavioral impairments and disrupted mitochondrial energy metabolism induced by polypropylene microplastics in zebrafish larvae
Zebrafish embryos exposed to polypropylene microplastics at environmentally relevant levels showed behavioral changes and disrupted energy production in their cells. The microplastics impaired the mitochondria -- the energy-producing structures inside cells -- in both intestinal and liver tissue, while also causing oxidative stress. These findings suggest that even at concentrations found in the environment, common polypropylene microplastics can interfere with basic cellular energy processes.
Polystyrene nanoplastics impact the bioenergetics of developing zebrafish and limit molecular and physiological adaptive responses to acute temperature stress
Researchers studied how polystyrene nanoplastics affect developing zebrafish under heat stress conditions and found that the combination impairs energy production at the cellular level. While nanoplastics alone did not visibly alter development, they reduced mitochondrial efficiency and limited the fish's ability to adapt to rising temperatures. The findings suggest that nanoplastic pollution could make aquatic organisms more vulnerable to the effects of climate change.
Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny
Researchers found that maternal exposure to polystyrene nanoplastics caused brain abnormalities in offspring, demonstrating that nanoplastics can cross maternal barriers and affect neurological development in progeny with implications for developmental toxicology.
Mitochondrial dysfunction and lipometabolic disturbance induced by the co-effect of polystyrene nanoplastics and copper impede early life stage development of zebrafish (Danio rerio)
Researchers found that co-exposure to polystyrene nanoplastics and copper at environmentally relevant concentrations caused mitochondrial dysfunction and lipid metabolism disruption in zebrafish embryos, impairing early development and survival more severely than either contaminant alone.
Polystyrene nanoplastics target electron transport chain complexes in brain mitochondria
Researchers investigated the effects of polystyrene nanoplastics on mitochondrial function in rat brain tissue. They found that nanoplastic exposure significantly impaired the electron transport chain, specifically disrupting electron flow between respiratory complexes I-III and II-III in both synaptic and non-synaptic mitochondria. The findings reveal a potential mechanism by which nanoplastics could contribute to brain energy metabolism deficits and neurotoxicity.
Female zebrafish (Danio rerio) exposure to polystyrene nanoplastics induces reproductive toxicity in mother and their offspring
Researchers exposed female zebrafish to polystyrene nanoplastics for six weeks and found the particles disrupted sex hormone levels and oocyte development, reducing egg production in the exposed generation and carrying endocrine disruption effects into unexposed offspring through the hypothalamic-pituitary-gonadal axis.
Polystyrene Nanoparticles Disrupt Oxidative Phosphorylation and Impair Placental Development in Mice
Researchers found that polystyrene nanoparticles disrupted placental development in mice by impairing energy production in placental mitochondria. The exposure led to decreased ATP production, increased oxidative stress, and altered signaling pathways important for placental growth and barrier function. The study provides evidence for a specific mechanism by which nanoplastic exposure during pregnancy could affect embryonic development.
Nanoplastics Decrease the Toxicity of a Complex PAH Mixture but Impair Mitochondrial Energy Production in Developing Zebrafish
Researchers studied the combined toxicity of polystyrene nanoplastics and a real-world mixture of polycyclic aromatic hydrocarbons on developing zebrafish. While the nanoplastics alone did not cause visible developmental defects, they impaired mitochondrial energy production and unexpectedly reduced the toxicity of the PAH mixture. The findings suggest that nanoplastics can interact with co-occurring pollutants in complex ways, sometimes moderating their effects while causing their own subtle cellular damage.
Plastic nanoparticles cause mild inflammation, disrupt metabolic pathways, change the gut microbiota and affect reproduction in zebrafish: A full generation multi-omics study.
Exposure of zebrafish to polystyrene nanoparticles throughout their entire first generation caused mild inflammation, disrupted metabolic pathways, altered gut microbiota, and impaired reproduction — even at environmentally relevant concentrations. This comprehensive multigenerational study demonstrates that nanoplastic exposure can have lasting biological effects across multiple body systems in fish.
Transgenerational effects of Nanoplastics and bisphenol A on Zebrafish lipid metabolism: Disruption of the gut Microbiota-liver axis via mTOR pathway
Researchers exposed zebrafish to nanoplastics and bisphenol A, a chemical commonly found in plastics, and tracked the effects across three generations. They found that the combined exposure disrupted fat metabolism, damaged gut bacteria and liver function in the first generation, and these metabolic problems were passed down to offspring that were never directly exposed. The study suggests that nanoplastic and chemical co-exposure may cause health effects that persist across multiple generations.
Polystyrene nanoparticles cause dynamic alteration in mitochondrial unfolded protein response from parents to the offspring in C. elegans
Researchers investigated how polystyrene nanoparticles affect the mitochondrial stress response across generations in C. elegans nematodes. The study found that nanoparticle exposure suppressed the mitochondrial unfolded protein response in a dose-dependent manner from parents through to the second offspring generation, indicating that parental plastic exposure can compromise the cellular stress defenses of future generations.
Toxicological impacts of nanopolystyrene on zebrafish oocyte with insight into the mechanism of action: An expression-based analysis
Researchers investigated the mechanism by which nanopolystyrene causes toxicity in zebrafish oocytes, finding it triggers oxidative stress, immune disruption, and mitochondrial dysfunction through changes in key gene expression pathways.
Integrated transcriptomics and metabolomics reveal the mechanism of polystyrene nanoplastics toxicity to mice
Researchers used gene expression and metabolic profiling to understand how polystyrene nanoplastics harm mice at the molecular level, finding disrupted energy metabolism, fat processing, and amino acid pathways in the liver. These molecular changes suggest that nanoplastic exposure could contribute to metabolic disorders, with effects becoming more severe at higher doses.
A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo
Researchers exposed zebrafish embryos to nanoplastics made from PET, the plastic commonly used in water bottles and food packaging. The nanoplastics accumulated in the liver, intestine, and kidneys, causing oxidative stress, damaging cell energy systems, and disrupting metabolism. This is the first comprehensive study of PET nanoplastic toxicity mechanisms, and it is particularly relevant because PET is one of the most common plastics that humans encounter daily.
Polystyrene microplastics and nanoplastics induce neurotoxicity in zebrafish via oxidative stress and neurotransmitter disruption
Researchers exposed zebrafish embryos to polystyrene micro- and nanoplastics and found that both particle sizes caused neurodevelopmental toxicity, with nanoplastics being more potent. The plastic particles induced oxidative stress in the brain and disrupted neurotransmitter levels critical for normal neural development. The study suggests that microplastic and nanoplastic contamination in aquatic environments may pose significant risks to the neurological development of fish.
Maternal polystyrene nanoplastics exposure during pregnancy induces obesity development in adult offspring through disrupting lipid homeostasis
Researchers found that maternal inhalation exposure to polystyrene nanoplastics during pregnancy induced obesity development in adult offspring of mice, suggesting in utero exposure to airborne nanoplastics programs metabolic dysfunction. The study linked prenatal nanoplastic exposure to increased adiposity and metabolic changes persisting into adulthood.
Polystyrene Nanoplastic Exposure Induces Developmental Toxicity by Activating the Oxidative Stress Response and Base Excision Repair Pathway in Zebrafish (Danio rerio)
Researchers exposed zebrafish embryos to polystyrene nanoplastics at various concentrations and found significant developmental abnormalities including reduced hatching rates and increased malformations. The nanoplastics activated oxidative stress responses and DNA repair pathways, indicating cellular damage during critical early development stages. The study provides mechanistic evidence for how nanoplastic exposure can disrupt normal embryonic development in aquatic organisms.
Developmental toxicity of carboxylated microplastics in zebrafish mediated by mitochondrial dysfunction and inflammatory activation
Researchers exposed zebrafish larvae to carboxylated polystyrene microplastics at environmentally relevant concentrations (0.1–100 μg/L) and found dose-dependent developmental defects including reduced tail coiling and slowed heart rate, linked to mitochondrial dysfunction and inflammatory activation.
Maternal Polystyrene Microplastic Exposure during Gestation and Lactation Altered Metabolic Homeostasis in the Dams and Their F1 and F2 Offspring
Researchers exposed pregnant mice to polystyrene microplastics during pregnancy and nursing and found significant metabolic disruptions in both the mothers and their offspring across two generations. The microplastics altered lipid metabolism, gut microbiota composition, and key metabolic signaling pathways. The study suggests that microplastic exposure during critical developmental windows may have lasting health consequences that pass to future generations.
Aged polystyrene microplastics exposure affects apoptosis via inducing mitochondrial dysfunction and oxidative stress in early life of zebrafish
Zebrafish embryos exposed to UV-aged polystyrene microplastics at environmental concentrations showed more severe developmental problems than those exposed to fresh microplastics. The aged particles caused greater oxidative stress and mitochondrial damage, triggering increased cell death during early development -- suggesting that weathered microplastics in the real environment may be more harmful than the pristine particles typically used in lab studies.
Melatonin prevents the transgenerational toxicity of nanoplastics in zebrafish (Danio rerio)
This zebrafish study found that polystyrene nanoplastics caused harmful effects that passed from exposed parents to their offspring, including developmental problems and oxidative stress in the next generation. The hormone melatonin was able to protect against this transgenerational damage when given alongside the nanoplastic exposure. The findings suggest that nanoplastic exposure could affect not just the people exposed but potentially their children, and that antioxidants like melatonin might offer some protection.