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Polystyrene Nanoparticles Disrupt Oxidative Phosphorylation and Impair Placental Development in Mice
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Researchers found that polystyrene nanoparticles disrupted placental development in mice by impairing energy production in placental mitochondria. The exposure led to decreased ATP production, increased oxidative stress, and altered signaling pathways important for placental growth and barrier function. The study provides evidence for a specific mechanism by which nanoplastic exposure during pregnancy could affect embryonic development.
These changes collectively led to decreased mitochondrial ATP production, increased oxidative stress in the placenta, and potentially altered placental barrier function and trophoblast cell proliferation signalling. This study reveals a novel mechanism by which PS-NPs disrupt placental development and embryonic growth through impairment of placental energy metabolic homeostasis and key signalling pathways, thus providing crucial experimental evidence for assessing the reproductive and developmental toxicity of nanoplastics.
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Maternal exposure to polystyrene nanoparticles retarded fetal growth and triggered metabolic disorders of placenta and fetus in mice
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Researchers exposed pregnant mice to polystyrene nanoplastics through drinking water and found that higher concentrations led to significantly reduced fetal weight. The nanoplastics caused abnormal cell structures in the placenta and disrupted metabolic processes in both placental tissue and fetal livers. The study suggests that maternal nanoplastic exposure during pregnancy can cross the placental barrier and interfere with normal fetal growth and metabolism.
Maternal exposure to polystyrene microplastics alters placental metabolism in mice
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Researchers exposed pregnant mice to polystyrene microplastics and examined how placental metabolism was affected. The study found significant changes in placental metabolic pathways that could help explain the fetal growth restriction previously observed in microplastic-exposed pregnancies. These findings suggest that microplastic exposure during pregnancy may interfere with the placenta's ability to support normal fetal development.
Subchronic Exposure to Polystyrene Nanoplastics Disrupts Placental Development and Calcium Homeostasis: Insights from In Vivo and In Vitro Models
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Pregnant mice exposed to polystyrene nanoplastics through drinking water showed abnormal placental development, increased fetal loss, and disrupted calcium balance in placental cells. The nanoplastics triggered a specific molecular pathway that interfered with calcium signaling in the placenta, suggesting that prenatal nanoplastic exposure could harm fetal development through placental dysfunction.
Cellular uptake of micro and nano plastics Induces Mitochondrial Dysfunction
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Scientists found that tiny plastic particles from our environment can travel through the bloodstream and get absorbed into placenta cells, where they damage the cell's energy-producing "batteries" (mitochondria) and cause inflammation. In mouse and lab-based human cell studies, this damage weakened the cells' ability to function properly, raising concerns that microplastic exposure during pregnancy could potentially harm placental health and fetal development. More research is needed to confirm these effects in humans, but the findings suggest another reason to minimize plastic exposure during pregnancy.
Maternal Exposure to Polystyrene Micro- and Nanoplastics Causes Fetal Growth Restriction in Mice
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Researchers exposed pregnant mice to polystyrene micro and nanoplastics and found that exposure caused fetal growth restriction and placental abnormalities. The study observed that plastic particles accumulated in placental tissue and disrupted normal placental function. These findings raise concern that maternal exposure to plastic particles during pregnancy may interfere with fetal development.
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