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61,005 resultsShowing papers similar to Human Metabolism: A Regulatory Perspective
ClearA review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics
This review examines how environmental chemicals, including contaminants associated with plastics, can disrupt human metabolism and contribute to conditions like obesity and diabetes. Researchers mapped the connections between chemical exposure and changes in metabolic biomarkers that signal disease risk. The study highlights the emerging field of metabolism-disrupting chemicals and the importance of understanding how everyday environmental exposures influence long-term metabolic health.
A metabolomics perspective on the effect of environmental micro and nanoplastics on living organisms: A review
This review examines how scientists use metabolomics, the study of small molecules produced by cellular processes, to understand the toxic effects of microplastics and nanoplastics on living organisms. The research shows that these plastic particles disrupt metabolism in consistent ways across species, affecting energy production, fat processing, and amino acid pathways. These shared metabolic disruptions across different organisms suggest that microplastics could cause similar metabolic problems in humans.
Redox Regulation of Immunometabolism in Microglia Underpinning Diabetic Retinopathy
This review examines how redox regulation of immunometabolism in retinal microglia contributes to diabetic retinopathy progression. The study discusses how microglial activation involves tightly regulated metabolic reprogramming, and explores potential therapeutic targets within redox signaling pathways.
The Physiology of Reproduction – Quo vadis?
This review argues that reproductive physiology remains poorly understood at the systems level, with gamete production and gonadal hormone dynamics reflecting complex, redundant informational networks whose full quantitative and developmental dimensions — and vulnerability to environmental disruptors — are still largely uncharted.
Microplastic pollution: A potent threat for metabolic disruption in mammals
This review examines the evidence linking microplastic exposure to metabolic disruption, covering mechanisms by which microplastics and their associated chemical additives may interfere with hormonal regulation, glucose metabolism, and lipid homeostasis. The authors identify microplastics as a potent emerging threat to metabolic health.
Costs of molecular adaptation to the chemical exposome: a focus on xenobiotic metabolism pathways
This review examines how the human body processes foreign chemicals through specialized metabolic pathways, and how the sheer number of chemicals we are exposed to can overwhelm these defense systems. The pathways designed to detoxify harmful substances can generate toxic byproducts when they are overloaded or when multiple chemicals compete for the same enzymes. This is relevant to microplastics because they carry absorbed chemicals into the body, adding to the overall chemical burden that these metabolic pathways must handle.
Metabolomics-Based Insights Into the Toxicological Effects and Mechanisms of Microplastics: A Comprehensive Review.
This review of existing research shows that microplastics—tiny plastic particles found everywhere in our environment—can harm multiple body systems including the gut, brain, and reproductive organs. Scientists used a technique called metabolomics (studying how our body processes chemicals) to discover that microplastics disrupt normal metabolism, potentially affecting everything from digestion and brain function to fertility and child development. This research helps explain why microplastic pollution may be a serious health threat that requires urgent attention and solutions.
Metabolomics Approach in Environmental Studies: Methodologies, Application and Challenges
This review examines how metabolomics, the study of small molecules in biological systems, is being applied to environmental research to understand how chemical pollutants including microplastics affect organism metabolism. The study highlights metabolomics as a valuable tool for assessing the biological effects of environmental exposures at the molecular level, helping researchers identify biomarkers of pollutant exposure in both wildlife and humans.
Interactive effects of intrinsic and extrinsic factors on metabolic rate
This review explores how biological factors like body size and activity level interact with environmental factors like temperature and predation to influence metabolic rate in animals. Researchers found that most of these interactions are synergistic, meaning the combined effect is greater than either factor alone, which has important implications for predicting how organisms respond to changing environments.
Emerging environmental stressors and oxidative pathways in marine organisms: Current knowledge on regulation mechanisms and functional effects
This review summarized current knowledge on how emerging environmental pollutants including microplastics, heavy metals, and other stressors trigger oxidative stress in marine organisms, examining regulatory mechanisms from pre-transcriptional to catalytic levels.
Comparing The Physiological Function Of Insects And Humans To Explain Their Behavior.
This comparative review examined the physiological differences between insects and humans — including digestive systems, immune responses, and metabolic pathways — to explain behavioral and physiological parallels between these very different organisms. The comparison highlights insects as useful models for understanding basic biological processes.
Cellular mechanisms of microplastic and nanoparticle exposure and its relationship with metabolic diseases: Literature review
This literature review examined how microplastic and nanoparticle exposure affects cellular mechanisms related to metabolic disease, finding evidence that these contaminants disrupt insulin signaling, alter lipid metabolism, and may contribute to the development of metabolic syndrome.
Non-Classical Aspects of Obesity Pathogenesis and Their Relative Clinical Importance for Obesity Treatment
This review examines non-classical factors contributing to obesity beyond diet and exercise, including endocrine-disrupting chemicals, sleep quality, psychotropic medications, and light exposure at night, clarifying their clinical relevance for obesity prevention and treatment.
Current insights into the impact of plastic-derived pollutants (phthalates), microplastics, and nanoplastics on hypothalamic phenotype and molecular pathways: A scoping review
This scoping review integrates evidence on how phthalates, microplastics, and nanoplastics alter hypothalamic function and neuroendocrine pathways, finding that plastic-derived pollutants disrupt metabolic regulation through hypothalamic alterations with potential systemic consequences for energy balance and reproductive function.
Eco-toxicity of nano-plastics and its implication on human metabolism: Current and future perspective
This review examines the sources, bioaccumulation pathways, and potential health effects of nanoplastics on human metabolism. Researchers found that nanoplastics can enter the body primarily through ingestion of contaminated food and packaging, and evidence suggests they may interfere with metabolic pathways and contribute to organ dysfunction. The study highlights that significant knowledge gaps remain in assessing the human health risks of nanoplastic exposure.
Microplastics in Humans: A Critical Review of Biomonitoring Evidence and Immune–Metabolic Associations
This review critically evaluates the current evidence on microplastic detection in human tissues and biological fluids, focusing on methodological challenges and the potential biological mechanisms of action. Researchers found significant variation across studies due to differences in analytical techniques and sample handling protocols. The study highlights emerging evidence linking microplastic presence in the body to immune and metabolic disruptions, while noting that standardized detection methods are urgently needed.
Endocrine Disruptors in Cosmetic Products and the Regulatory Framework: Public Health Implications
This study examines endocrine-disrupting chemicals found in cosmetic and personal care products and how they may interfere with the hormonal systems of humans and wildlife. The researchers analyze the EU regulatory framework for these chemicals and highlight gaps at the interface of science and policy in managing health risks from cosmetic ingredients.
Central and Local Modulators of Reproduction and Fertility: An Update
This review updates current understanding of central and local modulators of reproduction and fertility, examining hormonal, neural, and local tissue-level regulatory mechanisms relevant to the increasing prevalence of infertility in industrialized countries. The study synthesizes recent advances in reproductive endocrinology and discusses factors disrupting fertility across multiple regulatory levels.
Navigating the Crossroads
This book chapter reviewed regulatory frameworks for industrial chemicals (REACH, TSCA, GHS) that govern adhesives, inks, cosmetics, agrochemicals, flame retardants, and other industrial outputs, addressing their human health and environmental risks. It provides context on how plastics and associated chemicals fit within broader chemical regulation.
Microplastic-Induced Cellular Stress: Emerging Mechanisms Linking Environmental Nanoparticles to Human Metabolic Disorders
This book reviewed emerging cellular mechanisms by which microplastics induce stress in human cells, with a focus on how environmental nanoparticles contribute to metabolic disorders. It connected microplastic exposure to oxidative stress, inflammation, and disruption of cellular homeostasis.
Microplastics: Environmental Ubiquity, Biological Fate, and Human Health Implications
This review summarizes the current understanding of microplastics as a growing global contaminant affecting both ecosystems and human health. Researchers note that microplastics can carry harmful compounds and have been found throughout the environment and in the human body, while global regulatory frameworks remain insufficient. The study calls for enhanced monitoring, stricter regulations, and source-reduction strategies to address the long-term risks of microplastic exposure.
Nutritional physiology and ecology of wildlife in a changing world
This review examined how environmental change — including chemical pollution and habitat degradation — affects the nutritional physiology and ecology of wildlife, providing a broad framework for understanding pollutant impacts on animal health.
The toxicity of nanoparticles and their interaction with cells: an in vitro metabolomic perspective
This review examines how nanoparticles interact with human cells and cause toxic effects, using a technique called metabolomics to track changes in cell chemistry. Understanding nanoparticle toxicity is relevant to microplastic research because nanoplastics behave similarly to other nanoparticles, penetrating cells and disrupting normal metabolic processes.
Physiological differences between wild and captive animals: a century-old dilemma
This commentary explores why laboratory animals often show different physiological responses compared to their wild counterparts, a longstanding challenge in experimental biology. Researchers discuss several mechanisms that may explain these discrepancies and propose strategies for improving how lab-based findings are applied to understanding wild animal physiology in the context of environmental change.