Papers

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Article Tier 2

Polystyrene microplastics do not affect juvenile brow trout (Salmo trutta f. fario) or modulate effect of the pesticide methiocarb

A controlled experiment exposing juvenile brown trout to polystyrene microplastics alone or combined with the pesticide methiocarb found no significant adverse effects on fish health or behavior at the tested concentrations. The results suggest that polystyrene microplastics may not amplify the toxicity of this pesticide in salmonid fish under short-term exposure.

2020
Article Tier 2

Do polystyrene microplastics affect juvenile brown trout (Salmo trutta f. fario) and modulate effects of the pesticide methiocarb?

Researchers exposed juvenile brown trout to polystyrene microplastics and the pesticide methiocarb, both alone and in combination. Neither microplastics alone nor the combination produced significant effects beyond what the pesticide caused by itself, but the study provides important baseline data on microplastic-pesticide interactions in a commercially important freshwater fish species.

2019 Research Square (Research Square)
Article Tier 2

Toxicity of polystyrene microplastics on juvenile Oncorhynchus mykiss (rainbow trout) after individual and combined exposure with chlorpyrifos

Researchers tested the effects of pristine and chlorpyrifos-loaded polystyrene microplastics on juvenile rainbow trout, examining tissue damage and physiological responses. They found that microplastics carrying the pesticide caused more severe histopathological changes in the gills and liver than either contaminant alone. The study provides evidence that microplastics can act as vectors for pesticides, amplifying their toxic effects on freshwater fish.

2020 Journal of Hazardous Materials 138 citations
Article Tier 2

Interacting Effects of Polystyrene Microplastics and the Antidepressant Amitriptyline on Early Life Stages of Brown Trout (Salmo trutta f. fario)

When brown trout eggs and larvae were exposed to polystyrene microplastics alone, there were no significant developmental or biochemical effects, but the antidepressant amitriptyline caused serious developmental harm and behavioral changes. Microplastics did not modify the toxicity of amitriptyline, suggesting the two pollutants do not interact in this species.

2020 Water 36 citations
Article Tier 2

Effect of polystyrene microplastic and chlorpyrifos pesticide on superoxide dismutase activity in tissues of rainbow trout (Oncorhynchus mykiss)

Rainbow trout were exposed to polystyrene microplastics, the pesticide chlorpyrifos, and a combination of both, with researchers measuring effects on antioxidant enzyme activity. The combined exposure caused greater disruption to superoxide dismutase activity than either pollutant alone, suggesting microplastics can amplify pesticide toxicity in fish.

2020 Journal of Fisheries 1 citations
Article Tier 2

Combined polystyrene microplastics and chlorpyrifos decrease levels of nutritional parameters in muscle of rainbow trout (Oncorhynchus mykiss)

Researchers exposed rainbow trout to polystyrene microplastics combined with the pesticide chlorpyrifos and found that the combination significantly reduced key nutritional parameters (protein, lipid, and moisture content) in muscle tissue compared to either contaminant alone.

2021 Environmental Science and Pollution Research 41 citations
Article Tier 2

Acute toxicity of organic pesticides to Daphnia magna is unchanged by co-exposure to polystyrene microplastics

Daphnia magna were exposed to dimethoate (low log Kow) and deltamethrin (high log Kow) pesticides in the presence or absence of 1 μm polystyrene microplastics, and microplastics were found to have no effect on the acute toxicity of either pesticide. The study challenges the assumption that polystyrene MPs function as significant vectors altering pesticide bioavailability and toxicity to freshwater zooplankton.

2018 Ecotoxicology and Environmental Safety 113 citations
Article Tier 2

Toxicity of mixture of polyethylene microplastics and Up Grade® pesticide on Oreochromis niloticus juvenile: I. Hemato-biochemical and histopathological alterations

Researchers exposed juvenile Nile tilapia to a pesticide and polyethylene microplastics, both individually and in combination, and measured blood chemistry changes and organ damage over 15 days. The combination treatment caused more severe effects than either pollutant alone, including reduced red blood cell counts, elevated liver enzymes, and significant tissue damage to the gills and intestines. The study demonstrates that microplastics can worsen the toxic effects of agricultural pesticides on commercially important fish species.

2023 Environmental Toxicology and Pharmacology 21 citations
Article Tier 2

Effects of the Antidepressant Amitriptyline on Juvenile Brown Trout and Their Modulation by Microplastics

Researchers exposed juvenile brown trout to the antidepressant amitriptyline with and without polystyrene microplastics and found that microplastics modulated the pharmaceutical's effects on fish behavior and physiology, highlighting the complexity of combined pharmaceutical-plastic pollution in aquatic ecosystems.

2022 Toxics 7 citations
Article Tier 2

Polystyrene microplastics modulate the toxic effects of bisphenol A in the early stages of zebrafish development

This study investigated whether polystyrene microplastics affect the toxicity of bisphenol A (BPA) during zebrafish embryo development by co-exposing fish to both contaminants. The PS microplastics modulated BPA toxicity in complex ways—in some developmental endpoints amplifying harm, in others providing partial protection—underscoring the unpredictability of combined plastic-chemical exposures.

2025 Environmental Toxicology and Pharmacology
Article Tier 2

Combined toxic effects of polystyrene microplastics and 3,6-dibromocarbazole on zebrafish (Danio rerio) embryos

Researchers exposed zebrafish embryos to polystyrene microplastics along with a brominated pollutant (3,6-dibromocarbazole) and found that the combination produced unexpected results. While each pollutant individually caused oxidative stress and cell death, together they actually reduced these effects -- an antagonistic interaction. However, the microplastics acted as carriers that increased the accumulation of the toxic chemical in the fish, potentially amplifying its longer-term dioxin-like toxicity.

2024 The Science of The Total Environment 28 citations
Article Tier 2

Toxic effects of polystyrene microplastics on atrazine in zebrafish: Exogenous toxicity and endogenous mechanism

Researchers found that combining polystyrene microplastics with the common herbicide atrazine was more toxic to zebrafish than either pollutant alone, causing greater liver and gut damage. The combination also degraded water quality by reducing oxygen levels and increasing harmful nitrogen compounds. This is important because microplastics and pesticides frequently co-exist in the environment, meaning their combined effects on aquatic life and food safety may be worse than studies of individual pollutants suggest.

2025 Environmental Pollution 6 citations
Article Tier 2

Effects of a microplastic exposure gradient on juvenile lake trout (Salvelinus namaycush)

Researchers exposed newly hatched lake trout for 12 weeks to three types of microplastics, polyethylene, polystyrene, and polyethylene terephthalate, at a gradient of concentrations to assess effects on early life stages of this important sportfish. Microplastic exposure caused growth and developmental effects in juvenile lake trout, with responses varying by polymer type and concentration.

2024 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Low level of polystyrene microplastics decreases early developmental toxicity of phenanthrene on marine medaka (Oryzias melastigma)

Researchers exposed marine medaka fish eggs to low levels of polystyrene microplastics combined with the pollutant phenanthrene. Surprisingly, they found that a very low concentration of microplastics actually reduced the developmental toxicity of phenanthrene, improving hatch rates and decreasing malformations. The study suggests this protective effect occurs because the microplastics reduce the bioavailability of the chemical pollutant, challenging the assumption that microplastics always worsen the toxicity of co-occurring contaminants.

2019 Journal of Hazardous Materials 144 citations
Article Tier 2

Complex combined effects of polystyrene nanoplastics and phenanthrene in aquatic models

Researchers investigated the combined toxicity of polystyrene nanoplastics and the pollutant phenanthrene in fish cells and zebrafish larvae. They found that the interaction between nanoplastics and phenanthrene was complex and tissue-dependent, with nanoplastics increasing phenanthrene uptake in some cell types while decreasing it in others. Interestingly, zebrafish larvae experienced lower overall toxicity during co-exposure compared to single-pollutant exposure, suggesting the interaction dynamics are more nuanced than previously assumed.

2025 Journal of Hazardous Materials 1 citations
Article Tier 2

Effects of different types of primary microplastics on early life stages of rainbow trout (Oncorhynchus mykiss)

Researchers examined the effects of polystyrene, PET, and polyethylene microplastics on rainbow trout early life stages over 69 days, finding elevated stress hormones and DNA damage despite no significant changes in hatching success or larval survival.

2021 The Science of The Total Environment 36 citations
Article Tier 2

Combined impacts of organophosphate pesticide and polyamide microplastics on growth, hematology, and immune responses in juvenile striped catfish (Pangasianodon hypophthalmus)

Researchers exposed juvenile striped catfish to both polyamide microplastics and an organophosphate pesticide, finding that the combination caused more severe growth reduction, immune suppression, and organ damage than either pollutant alone — evidence that microplastics and pesticides can act together to amplify harm in freshwater fish.

2025 Emerging contaminants 5 citations
Article Tier 2

Polystyrene Microplastics Modulate the Toxicity of the Hydrophilic Insecticide Thiacloprid for Chironomid Larvae and Also Influence Their Burrowing Behavior

Researchers found that polystyrene microplastics altered the toxicity of the hydrophilic insecticide thiamethoxam to aquatic invertebrates, with the combined exposure producing different effects than either stressor alone. The study highlights that microplastics can act as vectors that change the bioavailability and ecotoxicological impact of water-soluble pesticides.

2022 Microplastics 8 citations
Article Tier 2

Evaluation of single and combined effects of cadmium and micro-plastic particles on biochemical and immunological parameters of common carp (Cyprinus carpio)

Researchers investigated the individual and combined toxicity of cadmium and polystyrene microplastics on common carp over 30 days. They found that co-exposure to both pollutants produced more severe effects on liver enzymes, immune function, and biochemical markers than either pollutant alone. The study suggests that microplastics can enhance the toxicity of heavy metals in aquatic organisms, raising concerns about the combined impact of these co-occurring contaminants.

2019 Chemosphere 323 citations
Article Tier 2

Co-exposure to polystyrene plastic beads and polycyclic aromatic hydrocarbon contaminants in fish gill (RTgill-W1) and intestinal (RTgutGC) epithelial cells derived from rainbow trout (Oncorhynchus mykiss)

Using rainbow trout gill and intestinal cell lines, this study found that co-exposure to polystyrene microplastics and polycyclic aromatic hydrocarbons did not consistently increase toxicity compared to PAHs alone, suggesting limited vector enhancement at tested concentrations.

2019 Environmental Pollution 55 citations
Article Tier 2

Polystyrene nanoplastics enhance the toxicological effects of DDE in zebrafish (Danio rerio) larvae

Researchers found that polystyrene nanoplastics enhanced the toxicity of the pesticide metabolite DDE in zebrafish larvae, with co-exposure causing greater developmental abnormalities and oxidative stress than either pollutant alone.

2022 The Science of The Total Environment 38 citations
Article Tier 2

Combined effects of microplastics and benzo[a]pyrene on Asian sea bass Lates calcarifer growth and expression of functional genes

Researchers exposed juvenile Asian sea bass to polyethylene microplastics and the carcinogen benzo[a]pyrene, both individually and in combination, over 56 days. They found that co-exposure caused more severe effects on growth and gene expression related to immune function and stress response than either contaminant alone. The study highlights that microplastics may worsen the toxic effects of chemical pollutants already present in marine environments.

2024 Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology 7 citations
Article Tier 2

Polystyrene microplastics alleviate the developmental toxicity of silver nanoparticles in embryo-larval zebrafish (Danio rerio) at the transcriptomic level

In a surprising finding, researchers discovered that when zebrafish embryos were exposed to both silver nanoparticles and polystyrene microplastics together, the microplastics actually reduced the toxic effects of the silver nanoparticles. The study suggests that microplastics may interact with other pollutants in complex ways, sometimes lessening rather than amplifying their harmful impacts on developing organisms.

2024 The Science of The Total Environment 9 citations
Article Tier 2

Evaluation of Detoxification‐Related Gene Expression, Oxidative Stress Biomarkers, and Blood Biochemical Parameters in Common Carp ( Cyprinus carpio ) Co‐Exposed to Polyethylene Microplastics and Deltamethrin

Researchers investigated whether polyethylene microplastics worsen the toxic effects of the insecticide deltamethrin in juvenile common carp over a 30-day exposure. The study found that co-exposure to microplastics and deltamethrin affected detoxification-related gene expression, oxidative stress biomarkers, and blood biochemistry, suggesting that microplastics can modify the bioavailability and toxicity of co-occurring pesticides in fish.

2026 Journal of Applied Toxicology