Papers

20 results
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Article Tier 2

Concerning influences of micro/nano plastics on female reproductive health: focusing on cellular and molecular pathways from animal models to human studies

This review summarizes research showing that micro- and nanoplastics can harm the female reproductive system in multiple ways, from reducing ovarian reserves and disrupting hormone balance to accumulating in the placenta and breast milk. Animal studies show these particles trigger oxidative stress and inflammation in reproductive tissues, and human studies have confirmed their presence in placental tissue and infant feces, raising concerns about effects on fertility and fetal development.

2024 Reproductive Biology and Endocrinology 38 citations
Article Tier 2

Impact of nanoparticles and nanoplastics on female reproductive health

This review examines the evidence on how nanoparticles and nanoplastics may affect female reproductive health after entering the body through dermal, oral, and inhalation routes. Researchers note that these materials have been found in human ovarian tissue, raising concern about their potential effects on fertility and reproductive outcomes. The study highlights the need for more research into the reproductive health implications of nanoplastic exposure.

2026 Biology of Reproduction
Article Tier 2

Toxicological effects of micro/nano-plastics on human reproductive health: A review

This review summarizes research on how micro- and nanoplastics affect human reproductive health in both men and women. Evidence from animal and lab studies shows that these particles can accumulate in reproductive organs, disrupt hormones, damage eggs and sperm, and cause inflammation and oxidative stress. While human studies are still limited, the growing body of evidence suggests that microplastic exposure is a potential threat to fertility that warrants further investigation.

2025 Toxicology Letters 7 citations
Review Tier 2

"Unseen Dangers: The Effects of Micro- and Nanoplastics on Human Reproductive Health - A Narrative Review"

This review examines the effects of micro- and nanoplastics on human reproductive health, covering evidence from in vitro, animal, and epidemiological studies showing that plastic particles can disrupt hormone signaling, sperm function, ovarian development, and placental integrity.

2025 Recent Advances in Inflammation & Allergy Drug Discovery
Article Tier 2

Exposição De Microplásticos E Nanoplásticos Ao Tecido Ovariano: Uma Revisão Integrativa

This integrative review examines the impact of micro- and nanoplastics on female ovarian tissue, synthesizing animal model studies showing damage to follicular structures, increased oxidative stress, and disrupted reproductive hormone signaling.

2025 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Understanding the impact of nanoplastics on reproductive health: Exposure pathways, mechanisms, and implications

This review summarizes existing research on how nanoplastics (tiny plastic particles smaller than one micrometer) affect reproductive health in animals and potentially humans. Studies show that nanoplastics can accumulate in reproductive organs including the placenta, and evidence from animal studies links exposure to hormone disruption, reduced fertility, and developmental problems. The authors highlight a significant knowledge gap about nanoplastic effects on human reproduction, despite growing evidence that these particles reach our reproductive systems.

2024 Toxicology 16 citations
Systematic Review Tier 1

Impact of microplastics on female reproductive health: insights from animal and human experimental studies: a systematic review

This systematic review of 15 experimental studies found that microplastic exposure significantly impairs ovarian function, decreases fertility rates, and disrupts hormone levels in female subjects. Several studies also reported negative effects on embryo development and offspring health, though study quality varied and more rigorous research is needed to confirm mechanisms.

2025 Archives of Gynecology and Obstetrics 10 citations
Review Tier 2

Effects of micro(nano)plastics on the reproductive system: A review

This review summarizes research on how micro and nanoplastics affect the reproductive system in both animal studies and cell experiments. Evidence indicates these particles can cross biological barriers, accumulate in reproductive organs, and disrupt hormones, egg development, and sperm quality. While human studies are still limited, the animal data suggests microplastic exposure may be a meaningful concern for reproductive health.

2023 Chemosphere 42 citations
Article Tier 2

Exposição De Microplásticos E Nanoplásticos Ao Tecido Ovariano: Uma Revisão Integrativa

This integrative review (in Portuguese) examines published evidence on the effects of micro- and nanoplastic exposure on female ovarian tissue morphology, finding disrupted folliculogenesis, oxidative stress, and hormonal interference reported across animal model studies.

2025 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Toxicity of microplastics and nanoplastics: invisible killers of female fertility and offspring health

This review summarizes research on how microplastics and nanoplastics affect female fertility across multiple species, from reproductive failure to developmental problems in offspring. The tiny particles can infiltrate the body through food, air, and skin, accumulating in reproductive tissues where they disrupt hormones and damage eggs. While animal studies cannot be directly applied to humans, the consistent findings across species raise serious concerns about the potential impact of microplastic exposure on women's reproductive health.

2023 Frontiers in Physiology 54 citations
Article Tier 2

Plastic Particles and Female Fertility: Pathways, Toxicity, and Analytical Challenges

This review examines the pathways, toxicity mechanisms, and analytical challenges associated with microplastic and nanoplastic impacts on female fertility. Evidence from animal studies indicates that these particles can accumulate in ovaries and placental tissue, inducing oxidative stress, inflammation, and granulosa cell death that diminishes ovarian reserve. The study notes that microplastics have been confirmed in human placentas and umbilical cord blood, and may disrupt the hormonal axis governing reproduction.

2026 Microplastics
Article Tier 2

Adverse health effects and mechanisms of microplastics on female reproductive system: a descriptive review

This review describes how microplastics, particularly polystyrene, can reach and accumulate in the female reproductive system through ingestion, inhalation, and skin contact. Animal studies suggest these particles may disrupt ovarian function, hormone balance, and fertility through oxidative stress and inflammation. While human evidence is still emerging, the research raises important questions about microplastic exposure and women's reproductive health.

2023 Environmental Science and Pollution Research 46 citations
Article Tier 2

The impact of microplastics on female reproduction and early life

This review examined the current evidence on how micro- and nanoplastics may affect female reproduction and early life development. Researchers found that studies in animals suggest microplastics can cross important biological barriers and may interfere with reproductive processes, though human data remains very limited. The study highlights the urgent need for standardized methods to measure human exposure and better understand potential reproductive health effects.

2023 Animal Reproduction 38 citations
Clinical Trial Tier 1

Reproductive toxicity and related mechanisms of micro(nano)plastics in terrestrial mammals: Review of current evidence.

This review of terrestrial mammal studies found that micro- and nanoplastics induce reproductive toxicity through oxidative stress, inflammation, endocrine disruption, and DNA damage, affecting both male and female fertility. In males, effects include blood-testis barrier disruption and impaired spermatogenesis, while females show compromised oocyte maturation, ovarian fibrosis, and diminished ovarian reserve, with particles also capable of crossing the maternal-fetal interface.

2024 Ecotoxicology and environmental safety
Systematic Review Tier 1

Exposure to micro- and nanoplastics and human reproductive outcomes: a systematic review

This systematic review summarizes existing research on whether micro and nanoplastics affect human fertility and pregnancy outcomes. While the evidence is still emerging, the review found that these particles have been detected in placenta and fetal tissue, raising important questions about potential effects on reproductive health that warrant further study.

2023 1 citations
Article Tier 2

Reproductive toxicity of micro- and nanoplastics

This review summarizes existing research on how micro- and nanoplastics harm reproduction across many species, from marine invertebrates to mammals. The particles can cause oxidative stress and hormone disruption, leading to reduced fertility, abnormal embryo development, and toxic effects that pass to offspring. The findings raise concerns that human reproductive health could be similarly affected given our increasing exposure to these particles.

2023 Environment International 101 citations
Article Tier 2

Research Progress in Reproductive Toxicity of Micro- and Nanoplastics on Males and Its Mechanisms

This review summarized research on the reproductive toxicity of micro- and nanoplastics (MNPs) in males, finding that MNPs accumulate in reproductive organs and cause toxicity through oxidative stress, hormonal disruption, and DNA damage, with implications for both animal and human reproductive health.

2025 Hans Journal of Food and Nutrition Science
Article Tier 2

Adverse effects of microplastics and nanoplastics on the reproductive system: A comprehensive review of fertility and potential harmful interactions

This review summarizes how microplastics and nanoplastics can harm both male and female reproductive systems by disrupting hormone signaling, damaging sperm and egg cells, and causing inflammation in reproductive tissues. Smaller nanoplastics are especially concerning because they can cross biological barriers more easily and reach the testes and ovaries. With global infertility rates rising, the authors highlight environmental plastic exposure as a factor that deserves more research attention.

2023 The Science of The Total Environment 99 citations
Article Tier 2

Microplastics in ovarian function and ozone-based mitigation strategies: Emerging evidence and translational implications

This review synthesized emerging evidence that microplastics accumulate in human follicular fluid, oocytes, placenta, and semen, causing oxidative stress, mitochondrial dysfunction, and meiotic disruption in reproductive cells, and discussed ozone-based strategies as potential mitigation approaches.

2025 Current Research in Toxicology
Article Tier 2

Effects of polystyrene nanoplastics on the female reproductive system in mice: Implications for ovarian function and follicular development

Researchers exposed female mice to polystyrene nanoplastics orally for 29 days and examined the effects on their reproductive systems. They found that nanoplastic exposure disrupted estrous cycles, impaired follicle development, and altered hormone levels in a dose-dependent manner. The study suggests that nanoplastics, due to their extremely small size, may cross biological barriers and accumulate in reproductive tissues, raising concerns about potential effects on fertility.

2025 Reproductive Toxicology 3 citations