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Exposição De Microplásticos E Nanoplásticos Ao Tecido Ovariano: Uma Revisão Integrativa

Zenodo (CERN European Organization for Nuclear Research) 2025 Score: 48 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
THAMYRES RODRIGUES DAMASCENO, MONIQUE DOMINGOS ROCHA, FLAVINNY NEVES RODRIGUES, YAGO PINTO DA SILVA, ANA BEATRIZ GRAÇA DUARTE

Summary

This integrative review (in Portuguese) examines published evidence on the effects of micro- and nanoplastic exposure on female ovarian tissue morphology, finding disrupted folliculogenesis, oxidative stress, and hormonal interference reported across animal model studies.

Body Systems
Study Type In vivo

INTRODUÇÃO: OS MICROPLÁSTICOS E NANOPLÁSTICOS SÃO PEQUENOS FRAGMENTOS DE PLÁSTICOS QUE POSSUEM EFEITOS NO SISTEMA REPRODUTIVO DE FÊMEAS, DEVIDO ÀS CÉLULAS GERMINATIVAS SEREM SUSCETÍVEIS A FATORES AMBIENTAIS. ENTRETANTO, AINDA SE FAZ NECESSÁRIO MAIS ESTUDOS PARA COMPREENDER OS IMPACTOS DESSES PLÁSTICOS AO SISTEMA REPRODUTOR DE FÊMEAS OBJETIVO: ESTA REVISÃO INTEGRATIVA VISA EXPLORAR OS PRINCIPAIS RESULTADOS PRESENTES NA LITERATURA SOBRE OS IMPACTOS DOS MICRO E NANOPLÁSTICOS NA MORFOLOGIA DO TECIDO OVARIANO. MÉTODOS: ESTA REVISÃO FOI REGISTRADA NO PROPSERO SOB O SEGUINTE NÚMERO 1131979. A BUSCA NA LITERATURA FOI CONDUZIDA NOS BANCOS DE DADOS PUBMED, SCOPUS E WEB OF SCIENCE EM JANEIRO DE 2024, UTILIZANDO OS DESCRITORES MICROPLASTICS, NANOPLASTICS, OVARY, TISSUES TOXICITY, OVARIAN E OS OPERADORES BOOLEANOS, AND E OR. OS CRITÉRIOS DE SELEÇÃO INCLUÍRAM ARTIGOS DOS ÚLTIMOS SETE ANOS, SEM RESTRIÇÃO DE IDIOMA, DISPONÍVEIS NA ÍNTEGRA E ABORDANDO A TEMÁTICA E PRINCIPAIS RESULTADOS. RESULTADOS: FORAM SELECIONADOS 13 ARTIGOS, ABRANGENDO ESTUDOS IN VIVO (CAMUNDONGOS E RATOS) E IN VITRO (CÉLULAS DA GRANULOSA). A PARTÍCULA PREDOMINANTE FOI POLIESTIRENO (PS) COM CONCENTRAÇÕES DE 50 NM A 5.9 ΜM, COM EXPOSIÇÃO POR GAVAGEM ORAL OU PRESENÇA NA ÁGUA DOS ANIMAIS COM DURAÇÃO DO TRATAMENTO DE 24 HORAS A 90 DIAS. CONCLUSÃO: OS ESTUDOS REVISADOS REVELARAM QUE A EXPOSIÇÃO DE MICRO E NANOPLÁSTICOS RESULTOU EM ALTERAÇÕES HISTOLÓGICAS NO TECIDO OVARIANO E CÉLULAS DA GRANULOSA, REDUÇÃO NO CRESCIMENTO DE FOLÍCULOS, NA FERTILIZAÇÃO DE OVÓCITOS, NO DESENVOLVIMENTO E ANOMALIAS DE EMBRIÕES. NO ENTANTO, É IMPORTANTE DESTACAR QUE OS EFEITOS DESSAS PARTÍCULAS NA MORFOLOGIA DO TECIDO OVARIANO AINDA DEPENDEM DE MAIS EVIDÊNCIAS E ESTUDOS ADICIONAIS.

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