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61,005 resultsShowing papers similar to Enhanced hepatic cytotoxicity of chemically transformed polystyrene microplastics by simulated gastric fluid
ClearHepatotoxic of polystyrene microplastics in aged mice: Focus on the role of gastrointestinal transformation and AMPK/FoxO pathway
This study found that polystyrene microplastics caused liver damage in aged mice, with the particles undergoing chemical changes as they passed through the digestive system that may have made them more harmful. The microplastics disrupted key metabolic pathways in the liver, triggered inflammation, and caused DNA damage through oxidative stress. The findings are especially concerning because older individuals may be more vulnerable to the liver-damaging effects of microplastic exposure.
Effects of weathering and simulated gastric fluid exposure on cellular responses to polystyrene particles
Researchers studied the effects of weathering and simulated gastric fluid exposure on cellular responses to polystyrene particles. The study suggests that environmental weathering can alter how micro- and nanoplastics interact with biological systems, with potential implications for understanding human health effects from ingested plastic particles.
Environmentally relevant UV-light weathering of polystyrene micro- and nanoplastics promotes hepatotoxicity in a human cell line
Researchers found that UV-weathered polystyrene micro- and nanoplastics at environmentally relevant concentrations induced hepatotoxicity in human liver cells and caused significant changes in gene expression related to liver disease pathways.
The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics
Researchers studied how the human digestive process changes the physical and biological properties of polystyrene nanoplastics. They found that digestive fluids altered the surface characteristics of the particles, potentially affecting how they interact with gut cells. The study suggests that the form of nanoplastics that actually reaches our intestines may behave differently than the pristine particles typically used in lab studies.
Uptake and toxicity of polystyrene micro/nanoplastics in gastric cells: Effects of particle size and surface functionalization
Researchers evaluated the uptake and toxicity of polystyrene micro- and nanoplastics in human gastric cells, comparing different sizes and surface treatments. The study found that smaller 50-nanometer particles were taken up at significantly higher rates, with positively charged aminated particles being the most toxic, causing cytotoxicity at lower concentrations and higher rates of cell death.
Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids
Using lab-grown human liver organoids, researchers showed that polystyrene microplastics caused liver cell damage even at concentrations found in the environment. The microplastics disrupted fat metabolism, increased harmful reactive oxygen species, and triggered inflammation in the liver tissue. This study provides early evidence that microplastic exposure could contribute to liver problems like fatty liver disease in humans.
Effects of polystyrene micro/nanoplastics on liver cells based on particle size, surface functionalization, concentration and exposure period
Researchers systematically studied the effects of polystyrene micro- and nanoplastics on human liver cells, varying particle size, surface chemistry, concentration, and exposure duration. They found that smaller particles were internalized more readily and that surface functionalization significantly influenced toxicity, with aminated particles causing the most cell damage. The study suggests that particle characteristics beyond just size play an important role in determining how micro- and nanoplastics affect human cells.
In vitro digestion of microplastics in human digestive system: Insights into particle morphological changes and chemical leaching
Researchers simulated human digestion on four common types of microplastics and found that stomach acid and digestive enzymes changed the particles' shape, surface texture, and caused them to release chemical additives. The study shows that microplastics are not inert once swallowed -- they are actively transformed in the gut, which could increase their ability to interact with intestinal tissues and release potentially harmful chemicals.
Impact of a real food matrix and in vitro digestion on properties and acute toxicity of polystyrene microparticles
Researchers examined how interaction with milk as a real food matrix and subsequent digestion affects the properties and toxicity of polystyrene microparticles. The study found that milk proteins form a corona on the particles that alters their surface charge and behavior, suggesting that the food context significantly influences how microplastics behave in the gastrointestinal tract.
PS-MPs Induced Inflammation and Phosphorylation of Inflammatory Signalling Pathways in Liver
Polystyrene microplastics (0.1 µm) induced inflammatory responses and activated multiple inflammatory signalling pathways in mouse and human liver cell lines after 28 days of exposure. The study identified specific phosphorylation cascades through which PS MPs trigger hepatic inflammation, linking microplastic exposure to liver damage mechanisms.
Evaluation of the potentiating effect of polystyrene microparticles on the toxicity of acrylamide and ethanol under conditions of combined treatment of mouse hepatocyte cell culture MH-22a
Researchers evaluated whether polystyrene microparticles potentiate the toxicity of co-occurring contaminants in marine organisms, finding that microplastics can act as vectors that enhance pollutant bioavailability and amplify toxic effects.
Influence of the digestive process on intestinal toxicity of polystyrene microplastics as determined by in vitro Caco-2 models
Researchers studied how the human digestive process transforms polystyrene microplastics and affects their intestinal toxicity using in vitro Caco-2 cell models. The study found that digestion formed a corona on microplastic surfaces without altering their chemical composition, and that smaller particles (100 nm) showed higher toxicity than larger ones (5 micrometers) regardless of digestive treatment.
Hepatic and metabolic outcomes induced by sub-chronic exposure to polystyrene microplastics in mice
Researchers studied the effects of sub-chronic polystyrene microplastic exposure on mouse livers using multiple analytical approaches. They found that microplastics accumulated in liver tissue and caused inflammation, oxidative stress, and disruption of normal metabolic processes including lipid and amino acid metabolism. The study suggests that prolonged microplastic ingestion may pose significant risks to liver health.
Gut microbiota dysbiosis exacerbates polystyrene microplastics-induced liver inflammation via activating LPS/TLR4 signaling pathway in ducks
This study found that polystyrene microplastics exacerbate gut microbiota dysbiosis in ducks, and that this disruption of the gut microbial community amplifies liver inflammation through the gut-liver axis, revealing a mechanism by which MP exposure causes hepatic injury.
Oral exposure to high concentrations of polystyrene microplastics alters the intestinal environment and metabolic outcomes in mice
In a mouse study, oral exposure to high concentrations of polystyrene microplastics caused fatty liver disease and abnormal blood lipid levels even without prior gut leakiness. The microplastics triggered intestinal inflammation through immune cells, disrupted gut bacteria, and altered how the body processes nutrients. These results suggest that swallowing microplastics could contribute to metabolic problems and liver disease in humans.
Disruption of hepatic metabolism in Lep KO mice.
Researchers found that polystyrene microplastics administered orally for nine weeks accumulated in liver tissue of leptin-knockout obese mice and induced histopathological liver alterations, including disruption of hepatic lipid, glucose, and amino acid metabolism.
Ingested plastic transfers hazardous chemicals to fish and induces hepatic stress
Researchers fed fish polyethylene plastic fragments collected from the ocean — which had absorbed surrounding pollutants — and found the fish bioaccumulated toxic chemicals and developed liver damage. The study demonstrates that ingested marine plastic acts as a delivery vehicle for harmful contaminants, compounding the health risks of plastic pollution in seafood.
Impact of the Oral Administration of Polystyrene Microplastics on Hepatic Lipid, Glucose, and Amino Acid Metabolism in C57BL/6Korl and C57BL/6-Lepem1hwl/Korl Mice
Researchers investigated the effects of orally administered polystyrene microplastics on liver metabolism in normal and obese mice over eight weeks. They found that microplastic exposure altered lipid, glucose, and amino acid metabolism pathways in the liver and adipose tissues. The study suggests that microplastic ingestion may disrupt hepatic metabolic functions, with potentially different impacts depending on baseline metabolic health status.
Potential toxicity of microplastics on vertebrate liver: A systematic review and meta–analysis
This meta-analysis of 118 studies found that microplastics damage vertebrate livers by inducing oxidative stress and intracellular toxicity, altering biotransformation processes, and disrupting lipid metabolism. Organisms at earlier life stages, exposed to smaller particles, and for longer durations showed the greatest liver damage, with catalase, GST, reactive oxygen species, and alkaline phosphatase levels progressively increasing with microplastic concentration.
Digestion of plastics using in vitro human gastrointestinal tract and their potential to adsorb emerging organic pollutants
Researchers simulated human digestion of polystyrene and polyethylene plastics and found that digestive processes fundamentally altered plastic surfaces, creating new functional groups and generating micro- and nanostructures that can detach. The study suggests that digested plastics have enhanced capacity to adsorb certain pollutants like triclosan and diclofenac, potentially increasing health risks from ingested plastic.
Oral exposure to polyethylene microplastics induces inflammatory and metabolic changes and promotes fibrosis in mouse liver.
Mice fed polyethylene microplastics in their food for 6 to 9 weeks developed liver inflammation, metabolic disruption, oxidative stress, and increased cell growth in the liver. The microplastics also worsened liver scarring (fibrosis) when tested in mice with pre-existing liver damage. This is the first study to show that ingesting polyethylene, the most common type of plastic, can directly damage the mammalian liver and could worsen existing liver conditions.
The effects of concentration, duration of exposure, size and surface function of polymethyl methacrylate micro/nanoplastics on human liver cells
Researchers tested the effects of polymethyl methacrylate micro- and nanoplastics on human liver cells, varying the particle concentration, exposure duration, size, and surface chemistry. They found that smaller particles and those with specific surface modifications caused greater cellular damage, including reduced viability and increased oxidative stress. The study suggests that the physical and chemical properties of microplastics play a critical role in determining their potential toxicity to human tissues.
Proinflammatory properties and lipid disturbance of polystyrene microplastics in the livers of mice with acute colitis
Researchers studied the effects of polystyrene microplastics on the livers of mice fed a high-fat diet and found that the particles triggered significant inflammatory responses and disrupted lipid metabolism. The microplastics worsened fat accumulation in the liver and activated inflammatory signaling pathways. The findings suggest that microplastic exposure combined with a high-fat diet may amplify liver damage and metabolic disturbances.
Silent Killers: The Alarming Impact of Microplastics Polystyrene on Catfish Liver Health
Researchers exposed catfish to polystyrene microplastics and documented severe liver damage including necrosis, steatosis, and oxidative stress, finding that even short-term exposure caused histopathological changes comparable to those seen with classic liver toxins.