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Environmentally relevant UV-light weathering of polystyrene micro- and nanoplastics promotes hepatotoxicity in a human cell line
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Researchers found that UV-weathered polystyrene micro- and nanoplastics at environmentally relevant concentrations induced hepatotoxicity in human liver cells and caused significant changes in gene expression related to liver disease pathways.
Environmentally-relevant concentrations of UV-weathered polystyrene micro and nanoplastics induce hepatotoxicity and considerable changes in gene expression of liver disease-relevant pathways.
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Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids
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Using lab-grown human liver organoids, researchers showed that polystyrene microplastics caused liver cell damage even at concentrations found in the environment. The microplastics disrupted fat metabolism, increased harmful reactive oxygen species, and triggered inflammation in the liver tissue. This study provides early evidence that microplastic exposure could contribute to liver problems like fatty liver disease in humans.
Enhanced hepatic metabolic perturbation of polystyrene nanoplastics by UV irradiation-induced hydroxyl radical generation
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Researchers found that ultraviolet light exposure changes the surface properties of polystyrene nanoplastics, making them more toxic to mouse livers than untreated particles. The UV-altered nanoplastics caused greater disruption to liver metabolism, triggering increased oxidative stress and inflammatory responses. The study highlights that environmental weathering can make nanoplastics more harmful over time, which means laboratory studies using pristine particles may underestimate real-world health risks.
Polycarbonate nanoplastics and the in vitro assessment of their toxicological impact on liver functionality
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Researchers found that polycarbonate nanoplastics and molecular by-products formed during photodegradation both induce toxicity toward hepatocellular functions in liver cell models, demonstrating dual harmful effects from a single degradation process.
Effects of polystyrene micro/nanoplastics on liver cells based on particle size, surface functionalization, concentration and exposure period
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Researchers systematically studied the effects of polystyrene micro- and nanoplastics on human liver cells, varying particle size, surface chemistry, concentration, and exposure duration. They found that smaller particles were internalized more readily and that surface functionalization significantly influenced toxicity, with aminated particles causing the most cell damage. The study suggests that particle characteristics beyond just size play an important role in determining how micro- and nanoplastics affect human cells.
Photoaged polystyrene nanoplastics induce perturbation of glucose metabolism in HepG2 cells via oxidative stress
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Researchers exposed human liver cells to polystyrene nanoplastics with varying degrees of UV-induced aging and found that photoaged particles caused more severe disruptions to glucose metabolism than pristine ones. Long-term photoaged nanoplastics triggered dose-dependent metabolic disorders through oxidative stress, while pristine particles only caused effects at high concentrations. The study suggests that weathered nanoplastics in the environment may pose greater health risks than fresh plastic particles.
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