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61,005 resultsShowing papers similar to Transcriptome sequencing and metabolite analysis reveal the toxic effects of nanoplastics on tilapia after exposure to polystyrene
ClearEffects of Acute Exposure to Polystyrene Nanoplastics on the Channel Catfish Larvae: Insights From Energy Metabolism and Transcriptomic Analysis
Researchers found that acute exposure to polystyrene nanoplastics disrupted energy metabolism in channel catfish larvae, with transcriptomic analysis revealing altered gene expression in pathways related to oxidative stress and metabolic processes.
Metabolomics reveals the toxicity of polystyrene nanoplastics in the gills of Acrossocheilus yunnanensis
Researchers used metabolomics to study how polystyrene nanoplastics affect the gills of the freshwater fish Acrossocheilus yunnanensis. They found that nanoplastic exposure caused oxidative stress, tissue lesions, and significant disruption of lipid metabolism, particularly glycerophospholipid and sphingolipid pathways. The study suggests that nanoplastics primarily harm fish gills by damaging tissue integrity and disrupting the lipid balance that maintains cell membrane function.
Long-Term Exposure to Polystyrene Nanoplastics Impairs the Liver Health of Medaka
Researchers found that three months of exposure to polystyrene nanoplastics caused significant liver damage in medaka fish, including oxidative stress, immune disruption, and altered gene expression related to lipid metabolism and detoxification pathways.
Transcriptome and Gene Family Analyses Reveal the Physiological and Immune Regulatory Mechanisms of Channa maculata Larvae in Response to Nanoplastic-Induced Oxidative Stress
Researchers exposed larvae of blotched snakehead fish to polystyrene nanoplastics at concentrations ranging from 0.05 to 20 mg/L and observed concentration-dependent damage to the liver and intestines. The nanoplastics triggered oxidative stress responses and affected genes involved in immune regulation and detoxification. The study suggests that nanoplastic pollution during early fish development could compromise both organ function and immune defenses.
Investigating Polystyrene Nano-Plastic Effects on Largemouth Bass (Micropterus salmoides) Focusing on mRNA Expression: Endoplasmic Reticulum Stress and Lipid Metabolism Dynamics
Researchers investigated how polystyrene nanoplastics affect the liver of largemouth bass, focusing on endoplasmic reticulum stress and fat metabolism. They found that nanoplastic exposure disrupted normal lipid processing and triggered stress responses in liver cells, altering the expression of genes involved in fat storage and energy regulation. The study suggests that nanoplastic pollution in freshwater environments may impair metabolic health in fish.
Polystyrene nanoplastic induces oxidative stress, immune defense, and glycometabolism change in Daphnia pulex: Application of transcriptome profiling in risk assessment of nanoplastics
Researchers used transcriptome sequencing to examine how polystyrene nanoplastics affect gene expression in the water flea Daphnia pulex. After 96 hours of exposure, they identified 208 genes with altered expression levels, linked to oxidative stress, immune defense, and sugar metabolism pathways. The study provides molecular-level evidence that nanoplastic pollution can trigger multiple stress responses in freshwater organisms.
Impact of a chronic waterborne exposure to polystyrene nanoplastics on the gilthead seabream (Sparus aurata): Combining traditional and multi-omics approaches
Researchers exposed gilthead seabream to environmentally relevant and elevated polystyrene nanoplastic concentrations for 28 days, finding no visible tissue damage or blood abnormalities but significant shifts in gut microbiome diversity and dose-dependent changes in plasma metabolites linked to energy metabolism, suggesting subtle long-term risks for aquaculture production.
Sub-chronic nanoplastic toxicity in Etroplus suratensis (Pisces, Cichilidae): Insights into tissue accumulation, stress and metabolic disruption
Researchers exposed pearl spot fish to polystyrene nanoplastics at different concentrations for 14 days and found that the particles accumulated in multiple organs with concentration-dependent distribution patterns. The nanoplastics caused elevated glucose and cholesterol levels, suppressed antioxidant defenses, and increased markers of oxidative damage and stress. Gene expression changes in stress response and growth-related genes suggest that nanoplastic exposure may impair both immune function and normal development in fish.
Sequencing data of Amphiprion ocellaris (clownfish) exposed to polystyrene nanoplastic
Researchers exposed clownfish to polystyrene nanoplastics at environmentally relevant and high concentrations for seven days and performed biochemical and transcriptomic analyses. The study found that even low-concentration exposure triggered significant gene expression changes indicating energy reallocation and stress responses, while high concentrations amplified these effects and activated additional inflammatory and detoxification pathways.
Sequencing data of Amphiprion ocellaris (clownfish) exposed to polystyrene nanoplastic
Researchers exposed clownfish to polystyrene nanoplastics at environmentally relevant and high concentrations for seven days and performed biochemical and transcriptomic analyses. The study found that even low-concentration exposure triggered significant gene expression changes indicating energy reallocation and stress responses, while high concentrations amplified these effects and activated additional inflammatory and detoxification pathways.
Integrated transcriptomics and metabolomics reveal the mechanism of polystyrene nanoplastics toxicity to mice
Researchers used gene expression and metabolic profiling to understand how polystyrene nanoplastics harm mice at the molecular level, finding disrupted energy metabolism, fat processing, and amino acid pathways in the liver. These molecular changes suggest that nanoplastic exposure could contribute to metabolic disorders, with effects becoming more severe at higher doses.
Effects of polystyrene microplastics acute exposure in the liver of swordtail fish (Xiphophorus helleri) revealed by LC-MS metabolomics
Researchers used metabolomics to investigate the effects of acute polystyrene microplastic exposure on swordtail fish livers. The study found that microplastic exposure caused significant alterations in metabolic pathways related to amino acid metabolism, lipid metabolism, and energy production, indicating broad metabolic disruption even after short-term exposure.
Application of transcriptomic profiling to investigate the toxicity mechanisms caused by dietary exposure of nanoplastics in fish
Researchers used transcriptomic profiling to evaluate the impact of dietary nanoplastic exposure on European sea bass, finding changes in gene expression in intestinal tissue after 21 days of feeding with polystyrene nanoparticle-containing food. The study suggests that while no significant changes were observed in enzymatic stress markers, nanoplastics may trigger subtle molecular-level responses in the fish gut.
Polystyrene Nanoplastics Induce Multi-Organ Toxicity in the Rainbow Trout (Oncorhynchus mykiss): An Integrated Assessment of Physiological, Immunological, and Molecular Responses
Rainbow trout were exposed to polystyrene nanoplastics at three concentrations for 28 days and assessed for physiological, immunological, and molecular responses across multiple organs. NPs accumulated in liver, spleen, and intestine, causing dose-dependent oxidative stress, immune dysregulation, and altered gene expression, demonstrating multi-organ toxicity in a commercially important fish species.
Plastic nanoparticles cause mild inflammation, disrupt metabolic pathways, change the gut microbiota and affect reproduction in zebrafish: A full generation multi-omics study.
Exposure of zebrafish to polystyrene nanoparticles throughout their entire first generation caused mild inflammation, disrupted metabolic pathways, altered gut microbiota, and impaired reproduction — even at environmentally relevant concentrations. This comprehensive multigenerational study demonstrates that nanoplastic exposure can have lasting biological effects across multiple body systems in fish.
Lipid-Rich diet protects aquatic vertebrates by reducing polystyrene nanoparticles deposition and alleviating harmful effects from exposure
Researchers showed in zebrafish that polystyrene nanoplastics accumulate selectively in a narrow intestinal segment and alter immune and lipid metabolism gene expression, and that a lipid-rich diet significantly reduced intestinal nanoplastic deposition and partially restored normal transcriptomic profiles.
Ecotoxicological effects of polystyrene nanoplastics on common carp: Insights into blood parameters, DNA damage, and gene expression
Exposing common carp to polystyrene nanoplastics caused significant DNA damage in blood and brain cells, along with changes in genes related to immune function and stress response. Higher concentrations led to more severe effects, and the nanoplastics also disrupted liver antioxidant defenses. Since carp are widely consumed fish, these findings raise questions about the safety of fish from nanoplastic-contaminated waters for human consumption.
Polystyrene microplastics induce gut microbiome and metabolome changes in Javanese medaka fish (Oryzias javanicus Bleeker, 1854)
Researchers found that polystyrene microplastic exposure altered gut microbiome composition and metabolic profiles in Javanese medaka fish, with effects on amino acid and lipid metabolism pathways suggesting microplastics can disrupt gut health in aquatic organisms.
Polystyrene nanospheres-induced hepatotoxicity in swamp eel (Monopterus albus): From biochemical, pathological and transcriptomic perspectives
Researchers exposed swamp eels to polystyrene nanoplastics for 28 days and found significant liver damage including oxidative stress, tissue abnormalities, and disrupted gene expression related to immune response and metabolism. Higher concentrations caused more severe liver injury, with changes detectable at both the biochemical and genetic levels. This study adds evidence that nanoplastic exposure can harm liver function in freshwater species important to aquaculture and local food supplies.
Nanoplastic contamination: Impact on zebrafish liver metabolism and implications for aquatic environmental health
Zebrafish exposed to polystyrene nanoparticles for 28 days showed significant disruptions in liver metabolism, including altered fat processing, signs of inflammation, oxidative stress, and DNA damage. Notably, at lower doses the liver's detox enzymes appeared to break down the nanoplastics themselves, while higher doses overwhelmed these defenses and caused more severe injury.
Nanoplastics impact the zebrafish (Danio rerio) transcriptome: Associated developmental and neurobehavioral consequences
Researchers exposed developing zebrafish larvae to polystyrene nanoplastics of two sizes and found dose-dependent accumulation in tissues along with swimming hyperactivity, despite no effects on mortality or hatching. Transcriptomic analysis revealed changes in gene expression associated with neurodegeneration and motor dysfunction at both high and low concentrations. The study suggests that nanoplastic exposure during early development can alter brain function and behavior in ways that may reduce organismal fitness.
Polystyrene nanoplastics target lysosomes and affect lipid metabolism in RTgutGC and head kidney macrophages from Oncorhynchus mykiss
Researchers investigated the subcellular targets of polystyrene nanoplastics in rainbow trout intestinal cells and head kidney macrophages, finding that PS-NPs co-localized with lysosomes but not mitochondria and did not trigger reactive oxygen species production or alter oxidative metabolism. RNASeq analysis further revealed effects on lipid metabolism pathways, indicating that lysosomal targeting and lipid disruption are key mechanisms of nanoplastic toxicity in fish cells.
Polystyrene microplastics induce molecular toxicity in Simocephalus vetulus: A transcriptome and intestinal microorganism analysis
Researchers exposed a freshwater crustacean to polystyrene nanoplastics and found widespread molecular-level damage, including oxidative stress, disrupted energy metabolism, and signs of neurotoxicity. The nanoplastics also significantly altered the animals' gut microbiome, increasing harmful bacteria and weakening intestinal barrier function. The study provides a detailed picture of how plastic pollution can affect freshwater organisms at the cellular and genetic level.
Transcriptional response provides insights into the effect of chronic polystyrene nanoplastic exposure on Daphnia pulex
RNA sequencing of Daphnia pulex after 21 days of polystyrene nanoplastic exposure identified 244 differentially expressed genes, with key downregulated genes involved in trehalose metabolism and chitin synthesis and upregulated genes involved in stress response pathways. The transcriptomic analysis reveals metabolic and immune disruption as central mechanisms of chronic nanoplastic toxicity in this keystone freshwater species.