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Polystyrene nanoplastic induces oxidative stress, immune defense, and glycometabolism change in Daphnia pulex: Application of transcriptome profiling in risk assessment of nanoplastics

Journal of Hazardous Materials 2020 167 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Yiming Li, Yiming Li, Yiming Li, Yiming Li, Zhiquan Liu, Zhiquan Liu, Zhiquan Liu, Yiming Li, Zhiquan Liu, Yiming Li, Yiming Li, Qichen Jiang Yiming Li, Yiming Li, Yiming Li, Zhiquan Liu, Zhiquan Liu, Zhiquan Liu, Zhiquan Liu, Yiming Li, Zhiquan Liu, Zhiquan Liu, Qichen Jiang Yiming Li, Yiming Li, Yiming Li, Zhiquan Liu, Zhiquan Liu, Yiming Li, Yiming Li, Yiming Li, Yiming Li, Yang Jiao, Zhiquan Liu, Zhiquan Liu, Zhiquan Liu, Zhiquan Liu, Zhiquan Liu, Zhiquan Liu, Edgar Pérez, Yiming Li, Qichen Jiang Qichen Jiang Yang Jiao, Yunlong Zhao, Yang Jiao, Zhiquan Liu, Qichen Jiang Zhiquan Liu, Qichen Jiang Qichen Jiang Qichen Jiang Qichen Jiang Qichen Jiang Qichen Jiang Yiming Li, Yiming Li, Zhiquan Liu, Zhiquan Liu, Zhiquan Liu, Ying Yang, Yang Jiao, Qiang Chen, Yunlong Zhao, Yiming Li, Zhiquan Liu, Qichen Jiang Yang Jiao, Qichen Jiang Qichen Jiang Qichen Jiang Qichen Jiang Yang Jiao, Zhiquan Liu, Qiang Chen, Yiming Li, Yunlong Zhao, Yiming Li, Yiming Li, Qichen Jiang Yiming Li, Yiming Li, Zhiquan Liu, Yinying Huang, Yunlong Zhao, Yunlong Zhao, Yang Jiao, Yunlong Zhao, Zhiquan Liu, Qichen Jiang Qichen Jiang Yiming Li, Qichen Jiang Yiming Li, Yunlong Zhao, Qichen Jiang Yunlong Zhao, Yunlong Zhao, Yang Jiao, Yiming Li, Qichen Jiang Qichen Jiang Qichen Jiang Qichen Jiang Yang Jiao, Qichen Jiang Zhiquan Liu, Yiming Li, Yinying Huang, Yinying Huang, Yunlong Zhao, Yunlong Zhao, Yunlong Zhao, Qichen Jiang Yunlong Zhao, Yunlong Zhao, Qichen Jiang Ying Yang, Yunlong Zhao, Yunlong Zhao, Yunlong Zhao, Yunlong Zhao, Yiming Li, Qichen Jiang Qichen Jiang Zhiquan Liu, Yinying Huang, Zhiquan Liu, Yunlong Zhao, Yunlong Zhao, Yunlong Zhao, Yunlong Zhao, Yunlong Zhao, Yunlong Zhao, Qichen Jiang Qichen Jiang Yiming Li, Zhiquan Liu, Zhiquan Liu, Qichen Jiang Zhiquan Liu, Qichen Jiang Yiming Li, Zhiquan Liu, Qichen Jiang Qichen Jiang

Summary

Researchers used transcriptome sequencing to examine how polystyrene nanoplastics affect gene expression in the water flea Daphnia pulex. After 96 hours of exposure, they identified 208 genes with altered expression levels, linked to oxidative stress, immune defense, and sugar metabolism pathways. The study provides molecular-level evidence that nanoplastic pollution can trigger multiple stress responses in freshwater organisms.

Polymers

Body Systems

Immune

Models

Daphnia

Aquatic environments are generally contaminated with nanoplastic material. As a result, molecular mechanisms for sensitive species like Daphnia are needed, given that mechanistic nanoplastic toxicity is largely unknown. Here, global transcriptome sequencing (RNA-Seq) was performed on D. pulex neonates to quantitatively measure the expression level of transcripts. A total of 208 differentially expressed genes (DEGs) were detected in response to nanoplastic exposure for 96 h, with 107 being up-regulated and 101 down-regulated. The gene functions and pathways for oxidative stress, immune defense, and glycometabolism were identified. In this study, D. pulex neonates provide some molecular insights into nanoplastic toxicity. However, more studies on DEGs are needed to better understand the underlying mechanisms that result as a response to nanoplastic toxicity in aquatic organisms.

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