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Long-Term Exposure to Polystyrene Nanoplastics Impairs the Liver Health of Medaka

Water 2022 23 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 50 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Yinfeng Zhou, Yinfeng Zhou, Yinfeng Zhou, Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Youji Wang Elvis Genbo Xu, Yinfeng Zhou, Yinfeng Zhou, Yinfeng Zhou, Zhao Li, Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Haijing Xu, Youji Wang Youji Wang Youji Wang Zhao Li, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Youji Wang Haijing Xu, Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Mingyou Li, Mingyou Li, Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Youji Wang Elvis Genbo Xu, Youji Wang Elvis Genbo Xu, Youji Wang Mingyou Li, Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Youji Wang Elvis Genbo Xu, Youji Wang Youji Wang Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Youji Wang Elvis Genbo Xu, Youji Wang Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang

Summary

Researchers found that three months of exposure to polystyrene nanoplastics caused significant liver damage in medaka fish, including oxidative stress, immune disruption, and altered gene expression related to lipid metabolism and detoxification pathways.

Polymers

Body Systems

Digestive Hepatic Immune

Models

Fish other

Nanoplastic (NP) has become a global environmental concern due to its potentially wide distribution and unknown impacts on organisms. Many laboratory studies have reported the short-term toxicity of NPs but their long-term effects are unclear. Here, the chronic hepatoxic effects of NPs (diameter 100 nm; 0, 10, and 104 items/L) in medaka (Oryzias latipes) were evaluated after three-month exposure by investigating the alterations in enzymatic biomarkers (digestion, oxidative status, and immunity) and histopathology in the liver. The trypsin and chymotrypsin activities of digestive enzymes were induced at a low concentration of NPs (10 items/L) but inhibited at high concentration (104 items/L); only the amylase activity was significantly decreased in all NP-treated medaka. Oxidative stress was also induced by NP exposure, which was indicated by the responsive superoxide dismutase and catalase. Lysozyme was significantly reduced after exposure to a high concentration of NPs, while alkaline phosphatase was significantly induced at a low concentration. Exposure to NPs also caused liver damage (e.g., congestion and dilated sinusoids). Taken together, our findings show that chronic exposure to NPs at low particle concentrations can impair the liver health of medaka by affecting liver enzymatic functions and causing histological damage. This implies potentially long-term threats of NPs to aquatic organisms, which call for more long-term aquatic toxicological studies on various species using low environmental concentrations.

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