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61,005 resultsShowing papers similar to Transcending toward Advanced 3D-Cell Culture Modalities: A Review about an Emerging Paradigm in Translational Oncology
ClearGlobal trends and hotspots in research on organoids between 2011 and 2020: a bibliometric analysis
A bibliometric analysis of organoid research from 2011 to 2020 identified drug screening, disease modeling, and personalized medicine as the dominant themes, while highlighting reproducibility and functional maturity as ongoing limitations. The authors predicted that bioengineering strategies to overcome these limitations would become the next major focus of the field.
The new era of cardiovascular research: revolutionizing cardiovascular research with 3D models in a dish
This review explores how three-dimensional cell and tissue models grown in the laboratory are transforming cardiovascular research. Researchers describe advances in organoids, heart-on-chip devices, and 3D-printed tissue constructs that better mimic human heart and blood vessel biology than traditional animal models. The study highlights how these new models could accelerate the discovery of treatments for heart disease while reducing reliance on animal testing.
Bridging systems biology and tissue engineering: Unleashing the full potential of complex 3D in vitro tissue models of disease
This review discusses how advanced three-dimensional tissue models grown in the laboratory could be combined with computational systems biology approaches to better study human diseases. Researchers argue that current analysis methods do not fully capture the complexity these tissue models offer, and that mathematical modeling could unlock deeper insights. The study outlines a framework for integrating these two fields to improve drug development and understanding of disease mechanisms.
Development of fish liver PLHC-1 spheroids and its applicability to investigate the toxicity of plastic additives
Researchers developed three-dimensional cell clusters (spheroids) from fish liver cells as a more realistic laboratory model for testing the toxicity of plastic additives, finding that spheroids responded differently from flat cell cultures — showing less cell death but greater changes in lipid chemistry. This 3D model better mimics how a real liver responds to chemical exposure, improving the reliability of aquatic toxicity testing for plastic-related chemicals.
AI-Enhanced Patient-Derived Cancer Organoids: Integrating Machine Learning for Precision Oncology
This review explores how combining patient-derived cancer organoids with artificial intelligence enables more precise drug sensitivity predictions and biomarker discovery in oncology research. While not directly related to microplastic research, the study demonstrates how AI and advanced biological models can be integrated to analyze complex datasets. The approaches described may inform future methods for studying how environmental contaminants interact with human tissues.
A Method to sort heterogenous cell populations based on migration in 2D and 3D environments
This paper presents a method to sort subpopulations of cancer and immune cells based on their migratory behavior in 2D and 3D environments. The research is focused on cell biology and cancer research and is not related to microplastics or environmental health.
Transforming Toxicity Assessment through Microphysiology, Bioprinting, and Computational Modeling
This review examines emerging alternatives to traditional animal-based toxicity testing, including microphysiology systems, bioprinted tissues, and computational models. Researchers found that these human cell-based platforms can better predict how chemicals and drugs affect human biology while also being more ethical and higher throughput. The study suggests these technologies could transform how chemical safety and drug development testing is conducted.
Microplastics and cancer progression: A comparative study of 2D and 3D gastric cancer models using ISO Compliant protocols
Researchers developed standardized methods based on ISO protocols to test how microplastic exposure affects gastric cancer cells in both traditional flat cell cultures and three-dimensional tumor models. They found that polyethylene and polypropylene microplastics increased cancer cell growth in both model types, though the particles did not directly penetrate the 3D tumor structures. The study suggests that microplastic exposure may promote cancer cell proliferation, warranting further investigation.
Recent Advances in Graphene Oxide-Based on Organoid Culture as Disease Model and Cell Behavior – A Systematic Literature Review
This review examines how graphene oxide materials can improve three-dimensional cell culture models called organoids, which mimic real organs for research purposes. While not directly about microplastics, organoid technology is increasingly being used to study how pollutants like microplastics affect human tissues. Better organoid models could help researchers more accurately assess the health risks of microplastic exposure on specific organs like the gut and liver.
Multi-cellular engineered living systems to assess reproductive toxicology
Researchers reviewed how multi-cellular engineered living systems — including organ-on-chip devices and organoids — are being used to model reproductive toxicology for chemicals and drugs, highlighting their advantages over animal models for studying the placenta, embryo development, and both male and female reproductive organs.
The Need to Implement Innovative Technologies to Advance Research on the Biotoxicity of Micro- and Nanoplastics
This review examines the limitations of current animal models for studying the biotoxicity of micro- and nanoplastics and argues for the adoption of innovative technologies such as organoids, organ-on-chip platforms, and advanced imaging. It calls for mechanistic studies that move beyond descriptive toxicity characterisation.
Advancing Microplastic and Nanoplastic Toxicity Assessment: Insights from Human Organoid Models
This review examines how human stem cell-derived organoids are being used to study the toxic effects of microplastics and nanoplastics on human tissues. Researchers found that organoid models of the gut, lung, brain, and other organs provide more human-relevant data than traditional animal testing for assessing plastic particle toxicity. The study suggests that organoid technology could significantly advance understanding of how microplastics affect human health at the tissue and organ level.
Organoids as a Tool for Assessing Drinking Water Safety and Guidelines Relevance
This review assessed the potential of organoids — three-dimensional tissue models derived from human cells — as tools for evaluating drinking water safety, particularly for contaminants like microplastics that conventional cell lines poorly model. Organoids offer greater tissue complexity and inter-individual variability, making them more realistic platforms for human health risk assessment.
Role of atomic force microscopy in characterization of heterotypic cancer spheroids and their interaction with microplastic particles
Researchers used atomic force microscopy to characterize the mechanical properties of heterotypic cancer spheroids made from lung cancer cells, fibroblasts, and macrophages, and examined their interactions with microplastic particles. While the study found correlations between spheroid stiffness and cancer cell growth rates, microplastic uptake under dynamic conditions was low, highlighting the need for more quantitative methods to study particle-cell interactions.
Human organoids to assess environmental contaminants toxicity and mode of action: towards New Approach Methodologies
This review explores how human organoids, miniature lab-grown organ models, can be used to test the toxicity of environmental contaminants including microplastics. These 3D tissue models offer a more accurate picture of how pollutants affect human cells than traditional lab tests, though more work is needed to simulate the chronic, low-dose exposures people actually experience.
Tumor Spheroid Uptake of Fluorescent Nanodiamonds Is Limited by Mass Density: A 4D Light-Sheet Assay
Researchers developed a new 4D light-sheet microscopy platform to study how fluorescent nanodiamonds penetrate tumor tissue models. They found that the nanoparticles' high density limited their ability to reach the interior of tumor spheroids, an important consideration for designing nanoparticle-based cancer treatments. While focused on nanodiamonds rather than microplastics, the study advances understanding of how nanoparticle physical properties determine their behavior in biological tissues.
Application of organoid technology in the human health risk assessment of microplastics: A review of progresses and challenges
This review examines how organoid technology -- miniature lab-grown versions of human organs made from stem cells -- can be used to study the health effects of microplastics more accurately than traditional animal testing. Organoids of the gut, lung, brain, liver, and other organs can better predict how microplastics affect human tissues, potentially accelerating our understanding of the real health risks these particles pose.
Interaction between Macrophages and Nanoparticles: In Vitro 3D Cultures for the Realistic Assessment of Inflammatory Activation and Modulation of Innate Memory
This study examined how human monocytes and macrophages interact with engineered nanoparticles using in vitro 3D culture models that better replicate tissue conditions than standard 2D cultures. The findings provide a more realistic assessment of nanoparticle-triggered immune and inflammatory responses relevant to both safety evaluation and medical applications.
Utilization of intestinal organoid models for assessment of micro/nano plastic-induced toxicity
This review examines the use of intestinal organoid models as a more physiologically accurate alternative to traditional cell cultures and animal experiments for studying micro- and nanoplastic toxicity. Researchers highlight that organoids can mimic the complex structure of intestinal tissue, providing better insight into how plastic particles affect the gut. The study suggests that while organoid-based research is still in its early stages, it holds significant promise for advancing our understanding of plastic-related health effects.
Intersection of nanomaterials and organoids technology in biomedicine
This review examines how nanomaterials including quantum dots, nanoparticles, and carbon-based materials are being applied to improve organoid construction and function in biomedical research, covering applications across multiple organ systems.
Neuropathogenesis-on-chips for neurodegenerative diseases
Researchers reviewed how miniaturized lab-on-a-chip devices that mimic brain tissue are being developed to study neurodegenerative diseases like Alzheimer's and Parkinson's, offering more realistic models than traditional animal tests. These microfluidic systems, combined with stem cells, could accelerate the discovery of new diagnostics and treatments for conditions that affect millions of people worldwide.
Human mini-brains for reconstituting central nervous system disorders
This review discussed advances in human brain organoids (mini-brains) for modeling central nervous system disorders, highlighting their potential to overcome limitations of animal models and accelerate drug development for neurological diseases.
Organoids as a Tool for Assessing Drinking Water Safety and Guidelines Relevance
This review argued for using organoids — three-dimensional human tissue models — as more relevant tools for assessing the toxicity of drinking water contaminants including microplastics. The authors describe how gut, kidney, and liver organoids can capture human-specific responses that conventional cell lines and animal models cannot.
Microfluidic system for efficient molecular delivery to artificial cell membranes
A novel microfluidic chip design was developed that forms stable lipid bilayer membranes and allows buffer replacement without membrane disruption, enabling precise study of drug-membrane interactions at the cell scale—advancing in vitro platforms for pharmaceutical screening.