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Papers
20 resultsShowing papers similar to The ancillary effects of nanoparticles and their implications for nanomedicine
ClearAn updated overview of some factors that influence the biological effects of nanoparticles
This review provides an updated look at how the size, shape, chemical composition, and surface properties of nanoparticles influence their biological effects when they enter the body. Researchers summarize how these physical characteristics determine how nanoparticles interact with proteins, cell receptors, and other biological molecules. The study highlights the importance of understanding these factors for both the safe design of medical nanoparticles and for assessing environmental nanoparticle risks.
Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review
Researchers reviewed how the physical and chemical properties of nanoparticles — including size, shape, surface charge, and material type — influence their toxicity in living cells and tissues, with relevance to both medical applications and environmental exposures like nanoplastics. Smaller particles are generally more toxic because they have greater surface area and can more easily penetrate cell membranes and trigger oxidative stress.
An Overview of Nanoparticle Properties and Their Bioactivity
This systematic review summarized the properties and bioactivity of nanoparticles (1-100 nm), covering how their size, shape, and surface characteristics influence their behavior in biological systems and their potential applications in microbiology.
The effect of nanomaterials on the innate immune system: therapeutic opportunities and immunological risks
This overview summarizes how nanomaterials — including nanoplastics — interact with the innate immune system, covering both therapeutic potential in drug delivery and diagnostic applications and the immunological risks of unintended nanomaterial exposure.
A double‐edged sword: The complex interplay between engineered nanoparticles and platelets
This review explores how engineered nanoparticles interact with platelets in the bloodstream, which can lead to either beneficial or harmful effects. Researchers found that depending on their size, shape, and surface properties, nanoparticles can activate or inhibit platelet function. The study suggests that understanding these interactions is critical for the safe development of nanomedicine drug delivery systems.
Potential Toxicity of Nanoparticles for the Oral Delivery of Therapeutics
This chapter reviews the potential toxic effects of nanoparticles used for oral drug delivery, examining how properties like size, surface area, surface charge, and chemistry influence biological interactions. While nanoparticles offer advantages for drug bioavailability, their unexpected interactions with biological systems raise significant safety concerns.
Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy
Researchers reviewed how engineering the protein corona — the layer of proteins that coats nanoparticles in biological fluids — through modifications like PEGylation and protein pre-coating can improve nanoparticle targeting for cancer drug delivery by controlling how immune cells recognize and clear the particles.
Reviewing nanoplastic toxicology: It's an interface problem
This review of nanoplastic toxicology argued that toxicity is fundamentally an interface problem — driven by surface properties, protein corona formation, and nano-bio interactions — and proposed mechanistic approaches borrowed from nanotoxicology to improve risk assessment frameworks.
The Immunotoxic Effects of Environmentally Relevant Micro- and Nanoplastics
Researchers characterized the immunotoxic effects of over 20 types of micro- and nanoplastic particles on macrophages and dendritic cells, finding that physicochemical properties such as size, shape, polymer type, and surface oxidation strongly influence immune cell responses.
Environmental dimensions of the protein corona
Researchers reviewed how nanomaterials entering natural environments acquire an "eco-corona" — a coating of proteins and other biomolecules that alters how organisms recognize and interact with the particles — and called for targeted research into how this coating changes during food chain transfer and affects ecotoxicity.
Potential and risks of nanotechnology applications in COVID-19-related strategies for pandemic control
Researchers reviewed the benefits and risks of using nanoparticles in pandemic control strategies, including mRNA vaccine delivery, antiviral face masks coated with metal nanoparticles, and biosensors, noting that while nanoparticles offer powerful new tools, they also carry risks such as immune reactions, hormonal disruption, and environmental contamination from improper disposal. The review calls for careful assessment of these trade-offs as nanotechnology becomes more central to public health responses.
Aquatic organisms modulate the bioreactivity of engineered nanoparticles: focus on biomolecular corona
This review examines how aquatic organisms influence the bioreactivity of engineered nanoparticles through the formation of a biomolecular corona in environmental settings. Researchers found that biological molecules shed by organisms can coat nanoparticle surfaces and significantly alter their behavior, toxicity, and fate in aquatic ecosystems beyond what standard laboratory toxicity studies capture.
Assessment on interactive prospectives of nanoplastics with plasma proteins and the toxicological impacts of virgin, coronated and environmentally released-nanoplastics
Researchers found that nanoplastics quickly coat themselves in blood proteins, forming a multi-layered "corona" that changes the proteins' shape and makes them biologically harmful; these protein-coated nanoplastics caused more DNA and cell damage in human blood cells than bare nanoplastics. The study highlights the need to regulate nanoplastics in medical products and better understand how they accumulate in the body.
Nanomaterials in Drug Delivery: Strengths and Opportunities in Medicine
This review covers how nanomaterials are being used to improve drug delivery for treating cancer and infections, offering better targeted therapy with fewer side effects. While not directly about microplastics, the research on how nanoparticles interact with human tissues provides insight into how similarly sized nanoplastics might behave once inside the body.
The Yin and Yang of epigenetics in the field of nanoparticles
This review explored how nanoparticles can both disrupt and therapeutically modulate epigenetic mechanisms, highlighting dual implications for environmental health risks from nanoplastic exposure and potential biomedical applications in drug delivery.
Nanopartículas y salud dermatológica: mecanismos biológicos que afectan la barrera cutánea
This bibliographic review investigated the long-term effects of nanoparticles used in cosmetics on the skin barrier, finding that nanoparticles can alter lipid composition, modify intercellular junction protein expression, trigger inflammatory responses, and negatively affect cutaneous microbiota — collectively compromising the skin's protective function.
Surface topography of nanoplastics modulates their internalization and toxicity in liver cells
Researchers found that the surface topography of nanoplastics significantly affects their internalization and toxicity in liver cells, revealing that surface roughness and texture modulate how these particles interact with cellular systems.
In Vitro and In Vivo Models to Assess the Immune-Related Effects of Nanomaterials
This review examines in vitro and in vivo models used to assess the immune effects of nanomaterials, comparing cell line, primary cell, and animal model approaches used by regulatory bodies to evaluate immunosafety of drugs, nanomaterials, and environmental contaminants including nanoplastics.
Do Engineered Nanomaterials Affect Immune Responses by Interacting With Gut Microbiota?
This review examined evidence that engineered nanomaterials including nanoplastics can indirectly modulate immune responses by altering gut microbiota composition, finding that while direct immunotoxicity is often mild, microbiome disruption provides an indirect pathway through which nanomaterials may impair host immunity.
An integrative method for evaluating the biological effects of nanoparticle-protein corona.
Researchers developed an integrative method combining dynamic light scattering, transmission electron microscopy, and cellular assays to evaluate how protein corona formation on nanoplastic surfaces alters their biological interactions, finding that corona composition significantly changes cellular uptake pathways and cytotoxicity profiles.