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61,005 resultsShowing papers similar to Polystyrene nanoplastics and lung cancer: Insights from network toxicology and mechanistic in vitro studies
ClearUnveiling the Pulmonary Toxicity of Polystyrene Nanoplastics: A Hierarchical Oxidative Stress Mechanism Driving Acute–Subacute Lung Injury
Researchers investigated the pulmonary toxicity of polystyrene nanoplastics smaller than 100 nm in lung epithelial cells and macrophages, finding that exposure triggered a hierarchical oxidative stress mechanism that drove acute to subacute lung injury through lipid peroxidation and inflammation.
Chronic Exposure to Polystyrene Nanoplastics Promotes Lung Cancer Progression via Activating Gluconeogenesis and Inhibiting Glycolysis
Researchers found that long-term exposure to polystyrene nanoplastics promoted lung cancer cell growth and migration by reprogramming cellular metabolism. The study suggests nanoplastics activate a specific metabolic pathway through the stress-response protein ATF3, shifting energy production in ways that enhance cancer cell proliferation.
Polystyrene Nanoplastics Induce Lung Injury via Activating Oxidative Stress: Molecular Insights from Bioinformatics Analysis
Researchers found that polystyrene nanoplastics induce lung cell injury through oxidative stress pathways, identifying key transcription factors and the molecule TNFRSF12A as crucial mediators of nanoplastic-triggered redox imbalance and respiratory damage.
Polyethylene terephthalate microplastics promote pulmonary fibrosis via AKT1, PIK3CD, and PIM1: A network toxicology and multi-omics analysis
Using computational toxicology and multi-omics analysis, researchers identified three key proteins (AKT1, PIK3CD, and PIM1) through which PET microplastics may promote pulmonary fibrosis, a serious scarring disease of the lungs. The microplastics appear to affect metabolic and inflammatory pathways in specific lung and immune cells. This study provides molecular evidence for how inhaled plastic particles from everyday items could contribute to chronic lung disease.
Polystyrene nanoplastics and benzo(a)pyrene synergistically induce lung fibrosis and inflammation via relaxin signalling in mice
Researchers exposed mice to polystyrene nanoplastics, benzo(a)pyrene, or their combination over 16 weeks and found that only combined exposure produced significant lung inflammation and fibrosis, with transcriptomic analysis identifying the Relaxin signaling pathway — acting through PI3K-AKT, MAPK, and calcium-dependent macrophage trap formation — as a key mediator of the synergistic toxicity.
Polystyrene nanoplastics mediate oxidative stress, senescence, and apoptosis in a human alveolar epithelial cell line
A cell study found that polystyrene nanoplastics cause dose-dependent damage to human lung cells, triggering oxidative stress, premature cell aging, and cell death. These findings suggest that breathing in nanoplastics could harm lung tissue over time and potentially contribute to cancer risk from air pollution.
Internalization and toxicity: A preliminary study of effects of nanoplastic particles on human lung epithelial cell
Researchers studied the effects of polystyrene nanoplastic particles on human lung cells and found that the particles were internalized by the cells and caused dose-dependent toxicity. The nanoplastics triggered oxidative stress, inflammation, and disrupted normal cell function. The findings suggest that inhaling airborne nanoplastics may pose risks to respiratory health.
Pulmonary hazards of nanoplastic particles: a study using polystyrene in in vitro models of the alveolar and bronchial epithelium
Lab tests on human lung cell models found that polystyrene nanoplastics did not cause immediate cell death but did interfere with key lung functions like surfactant and mucus production and immune signaling. This means standard toxicity tests may underestimate the real danger of inhaling nanoplastics, and researchers need to look beyond simple cell survival to understand the true health effects on the lungs.
Polystyrene nanoplastics induced lung injury in mice: Insights into lung metabolic disorders
Researchers exposed mice to polystyrene nanoplastics through the airway and found that the particles caused lung inflammation and tissue damage. Using metabolomics analysis, they discovered that the nanoplastics disrupted multiple metabolic pathways in lung tissue, with surface-modified particles causing more severe effects. The study provides evidence that inhaled nanoplastics can alter lung metabolism in ways that may contribute to respiratory health problems.
In vitro evaluation of nanoplastics using human lung epithelial cells, microarray analysis and co-culture model
Researchers tested polystyrene nanoplastics on two types of human lung cells and found that the particles caused cell damage, oxidative stress, and inflammation-related gene changes at relatively low concentrations. Using a co-culture model that mimics the lung's layered structure, they showed that nanoplastics can trigger immune responses even in cells not directly exposed. The study suggests that inhaled nanoplastics may pose respiratory health risks through both direct toxicity and inflammatory signaling.
Polystyrene nanoplastics increase migration in normal lung cells while inducing differential cytotoxicity in lung cancer cells
Researchers exposed normal and cancerous human lung cell lines to polystyrene nanoplastics (50–1000 nm) and found that while normal cells showed increased migration, cancer cells exhibited variable cytotoxicity, highlighting cell-type-specific responses to nanoplastic exposure.
Integrative network toxicology and molecular docking preliminarily explore the potential role of polystyrene microplastics in childhood obesity
Researchers used computational methods including network toxicology, machine learning, and molecular docking to explore how polystyrene microplastics might contribute to childhood obesity. They identified 40 overlapping genes between obesity-related and microplastic-affected pathways, concentrated in lipid metabolism and insulin signaling. The study suggests that polystyrene microplastics may act as environmental triggers capable of disrupting metabolic balance by interacting with key regulatory genes.
Polystyrene microplastic particles: In vitro pulmonary toxicity assessment
Researchers tested the effects of polystyrene microplastics on human lung cells in the laboratory and found that the particles triggered inflammation and oxidative stress. The microplastics also weakened the protective barrier function of lung tissue by depleting key structural proteins. The study suggests that inhaling microplastics may increase the risk of respiratory problems by damaging the lung's natural defenses.
Combined cytotoxicity of polystyrene nanoplastics and phthalate esters on human lung epithelial A549 cells and its mechanism
Researchers investigated the combined toxicity of polystyrene nanoplastics and common plasticizer chemicals (phthalate esters) on human lung cells. At lower nanoplastic concentrations, the particles actually reduced the toxicity of the plasticizers by adsorbing them, but at higher concentrations nanoplastics dominated and worsened overall cell damage. The study identified oxidative stress and inflammation as key mechanisms driving the combined toxic effects on lung tissue.
Assessment of cancer-related signaling pathways in responses to polystyrene nanoplastics via a kidney-testis microfluidic platform (KTP)
Researchers developed a kidney-testis microfluidic platform to assess cancer-related signaling pathway responses to polystyrene nanoplastics. The study found that nanoplastic exposure activated cancer-associated signaling pathways in both kidney and testis tissue models, providing new insights into the potential molecular mechanisms through which nanoplastics may affect organ health.
Microplastics and nanoplastics, emerging pollutants, increased the risk of pulmonary fibrosis in vivo and in vitro: A comparative evaluation of their potential toxicity effects with different polymers and size
Researchers compared the lung toxicity of microplastics and nanoplastics made from polystyrene, polyethylene, and polypropylene in mice and human lung cells. They found that all particle types induced signs of pulmonary fibrosis, inflammation, and tissue remodeling, with polystyrene nanoplastics causing the most severe effects. The study suggests that smaller nanoplastic particles and certain polymer types may pose greater risks to lung health.
Size-dependent toxicity of polystyrene microplastics in lung cells: An in vivo and in vitro study
Researchers investigated the size-dependent toxicity of polystyrene microplastics in lung cells using both mouse and cell culture models. The study found that smaller 1-micrometer particles accumulated more in lung tissue than larger particles and identified epithelial-mesenchymal transition as a key toxic mechanism, driven by ECM-MMP signaling cascades that contribute to lung injury.
Comparative evaluation of molecular mechanisms triggered by differently functionalized polystyrene nanoplastics in human colon cell lines
Researchers compared the molecular responses triggered by polystyrene nanoplastics with different surface chemical groups in human colon cell lines. The study investigated how the specific functionalization of nanoplastic surfaces influences the cellular and molecular pathways activated upon exposure in human intestinal tissue.