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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Environmental Sources Human Health Effects Nanoplastics Sign in to save

Polystyrene nanoplastics mediate oxidative stress, senescence, and apoptosis in a human alveolar epithelial cell line

Frontiers in Public Health 2024 47 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Cristina Milillo, Eleonora Aruffo, Piero Di Carlo, Antonia Patruno, Antonia Patruno, Marco Gatta, Annalisa Bruno, Melania Dovizio, Lisa Marinelli, Marilisa Pia Dimmito, Viviana di Giacomo, Cecilia Paolini, Mirko Pesce, Patrizia Ballerini

Summary

A cell study found that polystyrene nanoplastics cause dose-dependent damage to human lung cells, triggering oxidative stress, premature cell aging, and cell death. These findings suggest that breathing in nanoplastics could harm lung tissue over time and potentially contribute to cancer risk from air pollution.

Polymers
PS
Body Systems
Respiratory

Collectively, this investigation underscores the importance of concentration (dose-dependent effect) and exposure duration as pivotal factors in assessing the toxic effects of PS-NPs on alveolar epithelial cells. Greater attention needs to be directed toward comprehending the risks of cancer development associated with air pollution and the ensuing environmental toxicological impacts on humans and other terrestrial mammals.

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