0
Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Nanoplastics Policy & Risk Sign in to save

Pulmonary hazards of nanoplastic particles: a study using polystyrene in in vitro models of the alveolar and bronchial epithelium

Journal of Nanobiotechnology 2025 13 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 68 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Safaa Mawas, Sara Michelini, Safaa Mawas, Safaa Mawas, Øyvind P. Haugen, Sara Michelini, Sara Michelini, Ema Kurešepi, Ema Kurešepi, Anani Komlavi Afanou, Ema Kurešepi, Neža Repar, Neža Repar, Safaa Mawas, Anani Komlavi Afanou, Øyvind P. Haugen, Ema Kurešepi, Øyvind P. Haugen, Damjana Drobne Damjana Drobne Dorian Miremont, Dorian Miremont, Dorian Miremont, Damjana Drobne Damjana Drobne Katharina Jüngert, Safaa Mawas, Damjana Drobne Francesco Barbero, Anani Komlavi Afanou, Damjana Drobne Neža Repar, Neža Repar, Safaa Mawas, Sara Michelini, Damjana Drobne Dorian Miremont, Anani Komlavi Afanou, Neža Repar, Neža Repar, Katharina Jüngert, Katarina Šimunović, Damjana Drobne Damjana Drobne Ema Kurešepi, Damjana Drobne Damjana Drobne Damjana Drobne Ema Kurešepi, Ema Kurešepi, Ema Kurešepi, Sara Michelini, Sara Michelini, Damjana Drobne Stéphanie Devineau, Damjana Drobne Damjana Drobne Damjana Drobne Damjana Drobne Damjana Drobne Ema Kurešepi, Ema Kurešepi, Francesco Barbero, Francesco Barbero, Francesco Barbero, Francesco Barbero, Francesco Barbero, Francesco Barbero, Damjana Drobne Damjana Drobne Damjana Drobne Francesco Barbero, Katarina Šimunović, Neža Repar, Damjana Drobne Damjana Drobne Damjana Drobne Damjana Drobne Damjana Drobne Damjana Drobne Damjana Drobne Damjana Drobne Neža Repar, Neža Repar, Damjana Drobne Francesco Barbero, Francesco Barbero, Francesco Barbero, Ivana Fenoglio, Sonja Boland, Sonja Boland, Neža Repar, Katarina Šimunović, Francesco Barbero, Damjana Drobne Ivana Fenoglio, Damjana Drobne Francesco Barbero, Damjana Drobne Damjana Drobne Damjana Drobne Damjana Drobne Damjana Drobne Stéphanie Devineau, Stéphanie Devineau, Stéphanie Devineau, Damjana Drobne Damjana Drobne Damjana Drobne Damjana Drobne Damjana Drobne Francesco Barbero, Friedrich Paulsen, Damjana Drobne Katarina Šimunović, Damjana Drobne Damjana Drobne Charlotte Izabelle, Charlotte Izabelle, Charlotte Izabelle, Charlotte Izabelle, Damjana Drobne Damjana Drobne Dorian Miremont, Øyvind P. Haugen, Stéphanie Devineau, Stéphanie Devineau, Damjana Drobne Damjana Drobne Martin Schicht, Damjana Drobne Damjana Drobne Damjana Drobne Martin Schicht, Dorian Miremont, Shan Zienolddiny-Narui, Francesco Barbero, Damjana Drobne Sara Michelini, Stéphanie Devineau, Damjana Drobne Stéphanie Devineau, Stéphanie Devineau, Shan Zienolddiny-Narui, Damjana Drobne Damjana Drobne V. S. Ganin, Sara Michelini, Damjana Drobne Damjana Drobne V. S. Ganin, V. S. Ganin, V. S. Ganin, Damjana Drobne Martin Schicht, Stéphanie Devineau, Ivana Fenoglio, Friedrich Paulsen, Ivana Fenoglio, Stéphanie Devineau, Damjana Drobne V. S. Ganin, V. S. Ganin, Ema Kurešepi, Anani Komlavi Afanou, Friedrich Paulsen, Sonja Boland, Francesco Barbero, Friedrich Paulsen, Friedrich Paulsen, Sonja Boland, Damjana Drobne Francesco Barbero, Øyvind P. Haugen, Andreja Erman, Stéphanie Devineau, Anani Komlavi Afanou, Francesco Barbero, Ivana Fenoglio, Ivana Fenoglio, Ivana Fenoglio, Ivana Fenoglio, Ivana Fenoglio, Ivana Fenoglio, Ivana Fenoglio, Sara Michelini, Andreja Erman, Barbara Šetina Batič, Katharina Jüngert, Ivana Fenoglio, Charlotte Izabelle, Katharina Jüngert, Barbara Šetina Batič, Øyvind P. Haugen, Shan Zienolddiny-Narui, Shan Zienolddiny-Narui, Øyvind P. Haugen, Friedrich Paulsen, Øyvind P. Haugen, Øyvind P. Haugen, Damjana Drobne Damjana Drobne Damjana Drobne Damjana Drobne Katharina Jüngert, Katharina Jüngert, Anani Komlavi Afanou, Neža Repar, Neža Repar, Damjana Drobne Friedrich Paulsen, Ivana Fenoglio, Francesco Barbero, Damjana Drobne Barbara Šetina Batič, Anani Komlavi Afanou, Shan Zienolddiny-Narui, Ivana Fenoglio, Shan Zienolddiny-Narui, Neža Repar, Shan Zienolddiny-Narui, Shan Zienolddiny-Narui, Friedrich Paulsen, Anani Komlavi Afanou, Anani Komlavi Afanou, Neža Repar, Ivana Fenoglio, Damjana Drobne Ines Mandić-Mulec, Sonja Boland, Andreja Erman, Damjana Drobne

Summary

Lab tests on human lung cell models found that polystyrene nanoplastics did not cause immediate cell death but did interfere with key lung functions like surfactant and mucus production and immune signaling. This means standard toxicity tests may underestimate the real danger of inhaling nanoplastics, and researchers need to look beyond simple cell survival to understand the true health effects on the lungs.

Polymers
Study Type In vitro

Our results show that PS-Eu exposure does not induce acute cytotoxicity in these models, but affects cell-specific functions like surfactant, mucin, and cytokine production. This underscores the limitations of relying solely on standard cytotoxicity tests for particle hazard assessment and highlights the importance of investigating cell function-specific signaling pathways. To support researchers in hazard assessment, we propose specific classes of biomarkers to test in in vitro lung models.

Sign in to start a discussion.

Share this paper