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Comparative evaluation of molecular mechanisms triggered by differently functionalized polystyrene nanoplastics in human colon cell lines
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Researchers compared the molecular responses triggered by polystyrene nanoplastics with different surface chemical groups in human colon cell lines. The study investigated how the specific functionalization of nanoplastic surfaces influences the cellular and molecular pathways activated upon exposure in human intestinal tissue.
Comparative evaluation of molecular mechanisms triggered by differently functionalized polystyrene nanoplastics in human colon cell lines
More Papers Like This
Comparative evaluation of molecular mechanisms triggered by differently functionalized polystyrene nanoplastics in human colon cell lines
AI summary Read the abstract
Researchers compared the molecular mechanisms triggered by polystyrene nanoplastics with different surface functionalization in human colon cell lines. The study examined how surface chemistry of nanoplastic particles influences their biological interactions with intestinal cells, contributing to understanding of how nanoplastics may affect the human gastrointestinal system.
Comparative evaluation of molecular mechanisms triggered by differently functionalized polystyrene nanoplastics in human colon cell lines
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Researchers compared molecular mechanisms triggered by differently functionalized micro- and nanoplastics in human cells, assessing how surface chemistry affects cellular responses. Surface functionalization significantly altered the toxicity profile of particles, with some coatings increasing and others decreasing inflammatory and oxidative responses.
Comparative evaluation of molecular mechanisms triggered by differently functionalized polystyrene nanoplastics in human colon cell lines
AI summary Read the abstract
Researchers compared molecular and cellular mechanisms triggered by differently surface-functionalized micro- and nanoplastics in human intestinal and liver cells, finding that surface chemistry strongly determines biological effects. Functionalized particles elicited distinct patterns of oxidative stress, inflammation, and membrane damage compared to unfunctionalized particles.
Functionalized polystyrene nanoplastics induce distinct toxicity and transcriptomic changes in human intestinal Caco-2 cells
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Researchers exposed human intestinal Caco-2 cells to polystyrene nanoplastics with different surface functionalizations (plain, aminated, carboxylated) and assessed cytotoxicity, cellular uptake, and transcriptomic responses. Surface chemistry strongly determined both uptake efficiency and the pattern of gene expression changes, with aminated particles inducing the most severe cytotoxic and inflammatory responses.
Surface functionalization-dependent inflammatory potential of polystyrene nanoplastics through the activation of MAPK/ NF-κB signaling pathways in macrophage Raw 264.7
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Researchers studied how surface chemistry of polystyrene nanoplastics affects their ability to trigger inflammation in immune cells. They found that amino-functionalized nanoplastics caused the strongest inflammatory response by activating the MAPK and NF-kB signaling pathways and generating reactive oxygen species. The study demonstrates that the chemical coating on nanoplastics significantly determines their potential to cause immune system disruption.
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