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Papers
20 resultsShowing papers similar to Epithelial Barrier: Protector and Trigger of Allergic Disorders
ClearEpithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease
This review proposes the 'epithelial barrier hypothesis,' which suggests that modern environmental exposures, including microplastics, air pollution, and processed food additives, are damaging the protective barriers of our skin, gut, and airways. When these barriers break down, foreign substances and bacteria can enter the body and trigger allergic and inflammatory diseases, which have been increasing rapidly in recent decades. The research suggests microplastics may be one of many environmental factors driving the rise in conditions like asthma, food allergies, and eczema.
Epithelial Barrier Theory: The Role of Exposome, Microbiome, and Barrier Function in Allergic Diseases
This review presents the epithelial barrier theory, which proposes that damage to the body's protective barriers is a key driver of allergic diseases. Researchers identified numerous environmental factors including microplastics, nanoparticles, detergents, and processed food additives that can weaken epithelial barriers in the skin, lungs, and gut. The study suggests that the rising prevalence of allergies may be linked to increasing exposure to barrier-disrupting substances in our modern environment.
Environmental factors in epithelial barrier dysfunction
This review examines how environmental factors from the modern industrialized world -- including air pollution, detergents, nanoparticles, and microplastics -- damage the protective lining of the skin, gut, and airways. Researchers describe how these exposures degrade the proteins that hold barrier cells together, increasing permeability and triggering immune responses linked to allergies, asthma, and inflammatory conditions. The study presents an "epithelial barrier hypothesis" suggesting that widespread barrier dysfunction from environmental pollutants may be driving the rise of chronic inflammatory diseases.
Involvement and repair of epithelial barrier dysfunction in allergic diseases
This review summarizes how environmental factors including pollution, climate change, and industrial chemicals are damaging the protective barriers of our skin, airways, and gut, contributing to the rising rates of allergic diseases worldwide. The authors discuss the "epithelial barrier hypothesis," which proposes that repairing these damaged barriers could be a new strategy for preventing and treating allergies, asthma, and related conditions.
Intestinal barrier dysfunction and food allergy
This review applies the epithelial barrier hypothesis to food allergy, arguing that environmental exposures including microplastics, nanoplastics, food additives, and detergents disrupt gut and skin barriers and drive the rise in allergic disease.
Skin, gut, and lung barrier: Physiological interface and target of intervention for preventing and treating allergic diseases
This review summarizes how the protective barriers of our skin, gut, and lungs can be damaged by environmental factors including microplastics, leading to allergic conditions like asthma, food allergies, and eczema. The authors explain that a person's genetics, microbiome, and environmental exposures all contribute to barrier breakdown, and they highlight current treatments as well as gaps in care for these increasingly common conditions.
Recent advances in the epithelial barrier theory
This review explains the "epithelial barrier theory," which links the rise in allergies, autoimmune diseases, and other chronic conditions to environmental pollutants, including micro- and nanoplastics, that damage the protective lining of our skin, lungs, and gut. These pollutants can break down the tight junctions between cells, trigger inflammation, and allow harmful substances to enter the body, potentially contributing to the increase in chronic diseases seen worldwide.
Epithelial barrier hypothesis and the development of allergic and autoimmune diseases
This review examines the epithelial barrier hypothesis, proposing that exposure to over 200,000 chemicals introduced since the 1960s damages epithelial barriers, triggering microbial dysbiosis, immune responses, and the rising prevalence of allergic and autoimmune diseases.
Climate change and the epithelial barrier theory in allergic diseases: A One Health approach to a green environment
This review links climate change and increased environmental pollution to the weakening of epithelial barriers in the skin, gut, and lungs, contributing to the rise of allergic diseases worldwide. The paper specifically identifies microplastics alongside other pollutants as agents that damage epithelial barriers, suggesting a mechanism by which microplastic exposure could contribute to allergies and autoimmune conditions.
Dysregulation of the epithelial barrier by environmental and other exogenous factors
This review examines how environmental and industrial factors can damage the body's epithelial barriers, which serve as the first line of defense against external threats. Researchers found that exposure to agents linked to industrialization and urbanization, including microplastics and other pollutants, can disrupt these protective barriers and trigger immune responses. The study suggests that epithelial barrier dysfunction may play a key role in the increasing prevalence of allergic and inflammatory conditions.
Epithelial Barrier Hypothesis and Its Comparison with the Hygiene Hypothesis
This review examines the epithelial barrier hypothesis as a framework for understanding the rising prevalence of chronic inflammatory conditions in industrialized societies. Researchers propose that environmental factors associated with industrialization, including exposure to microplastics and other pollutants, may damage epithelial barriers in the skin, gut, and lungs, triggering immune responses that contribute to allergic, autoimmune, and metabolic conditions. The study suggests that the epithelial barrier hypothesis builds upon and complements earlier explanations like the hygiene hypothesis.
Beyond allergic progression: From molecules to microbes as barrier modulators in the gut-lung axis functionality
This review explores the epithelial barrier hypothesis, which proposes that dysfunction of gut and lung barriers can trigger allergic responses due to tolerance breakdown. Researchers examined how environmental factors including pollution, food additives, and microplastics can damage epithelial barriers and alter the gut-lung axis, while also discussing how dietary factors and the microbiome may modulate barrier integrity and allergic progression.
Lifestyle Changes and Industrialization in the Development of Allergic Diseases
This paper describes the "Epithelial Barrier Theory," which proposes that toxic substances in everyday products -- including microplastics, detergents, and air pollution -- damage the protective linings of our skin, lungs, and gut. This damage disrupts the body's microbiome and triggers inflammation that may help explain the global rise in allergies and other immune-related diseases over recent decades.
Effect of altered human exposome on the skin and mucosal epithelial barrier integrity.
This review examined how modern environmental exposures including microplastics, air pollutants, and chemical toxicants disrupt the epithelial barrier integrity of skin and mucous membranes, arguing that the 'exposome' of chronic low-level chemical exposures is a major but underappreciated driver of barrier dysfunction and associated inflammatory diseases.
A Survey on Environmental Protective and Risk Factors and Awareness Related to Epithelial Barrier Integrity, Microbiome and Allergic Diseases
This study developed new questionnaires to assess environmental exposures — including microplastics, air pollutants, and detergents — that damage epithelial barriers and contribute to allergic diseases. The epithelial barrier theory links these exposures to microbial dysbiosis and the sharp rise in allergic, autoimmune, and neuropsychiatric conditions since the 1960s.
The External Exposome and Allergies: From the Perspective of the Epithelial Barrier Hypothesis
This review examines how environmental changes including air pollution, global warming, and shifting dietary habits damage epithelial barriers in the body, contributing to increased rates of allergies and inflammation. The authors highlight the need for public awareness and government policies to address the health effects of environmental exposures on current and future generations.
Epithelial barrier dysfunction and associated diseases in companion animals: Differences and similarities between humans and animals and research needs
This review examines how environmental pollutants including microplastics, household chemicals, and air pollution are damaging the protective lining (epithelial barriers) of both humans and their pets. The "epithelial barrier theory" suggests that this damage contributes to the rise in allergies, autoimmune conditions, and other inflammatory diseases seen in recent decades. Since pets share our living environments and face similar exposures, studying their health effects can help us better understand the risks these pollutants pose to human health.
Epithelial barrier dysfunction, type 2 immune response, and the development of chronic inflammatory diseases
This review explains how everyday substances including microplastics, air pollutants, food additives, and household chemicals damage the protective lining of our body's surfaces (epithelial barriers). Even trace amounts of these substances can cause the barriers to become leaky, allowing bacteria and allergens to trigger chronic inflammation. The research suggests that microplastic exposure, alongside other modern pollutants, may be contributing to the rise in chronic inflammatory diseases over the past several decades.
Detergent‐induced eosinophilic inflammation in the esophagus: A key evidence for the epithelial barrier theory
Researchers found that detergents and surfactants can damage the esophageal epithelial barrier, providing key evidence for the epithelial barrier theory linking environmental pollutants including nano/microplastics to rising rates of allergic and autoimmune diseases.
Epithelial barrier theory in the context of nutrition and environmental exposure in athletes
This review explains how environmental pollutants including microplastics, cleaning product chemicals, and air pollution can damage the protective barriers lining the skin, lungs, and gut, leading to inflammation and disruption of the body's natural microbiome. Athletes face heightened risk because intense exercise increases breathing rate, processed food intake, and exposure to synthetic equipment and clothing. The findings suggest that microplastics are one of several modern pollutants that may be weakening the body's first line of defense against disease.