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Human Health Effects
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Epithelial barrier dysfunction, type 2 immune response, and the development of chronic inflammatory diseases
Current Opinion in Immunology2024
16 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 60
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
İsmail Öğülür,
İsmail Öğülür,
Yasutaka Mitamura,
Yağız Pat,
Cezmi A. Akdiş
Yağız Pat,
Duygu Yazıcı,
Duygu Yazıcı,
Yağız Pat,
Sena Ardıçlı,
Yağız Pat,
Sena Ardıçlı,
İsmail Öğülür,
İsmail Öğülür,
Cezmi A. Akdiş
Cezmi A. Akdiş
Yağız Pat,
Duygu Yazıcı,
Cezmi A. Akdiş
İsmail Öğülür,
Yağız Pat,
Özge Ardıçlı,
İsmail Öğülür,
İsmail Öğülür,
Duygu Yazıcı,
Yasutaka Mitamura,
Mübeccel Akdiş,
Duygu Yazıcı,
İsmail Öğülür,
Duygu Yazıcı,
Yağız Pat,
Duygu Yazıcı,
Duygu Yazıcı,
Duygu Yazıcı,
Cezmi A. Akdiş
Mübeccel Akdiş,
Yağız Pat,
Yağız Pat,
Sena Ardıçlı,
Yasutaka Mitamura,
İsmail Öğülür,
Yağız Pat,
Yasutaka Mitamura,
Duygu Yazıcı,
Duygu Yazıcı,
Yağız Pat,
Mübeccel Akdiş,
Sena Ardıçlı,
Cezmi A. Akdiş
İsmail Öğülür,
Özge Ardıçlı,
Özge Ardıçlı,
Duygu Yazıcı,
Mübeccel Akdiş,
Sena Ardıçlı,
Yasutaka Mitamura,
Yasutaka Mitamura,
Özge Ardıçlı,
Yağız Pat,
Sena Ardıçlı,
Cezmi A. Akdiş
Sena Ardıçlı,
Mübeccel Akdiş,
Yasutaka Mitamura,
Mübeccel Akdiş,
Duygu Yazıcı,
Yağız Pat,
Mübeccel Akdiş,
Mübeccel Akdiş,
Cezmi A. Akdiş
Cezmi A. Akdiş
Mübeccel Akdiş,
Mübeccel Akdiş,
Sena Ardıçlı,
Cezmi A. Akdiş
Mübeccel Akdiş,
İsmail Öğülür,
Mübeccel Akdiş,
Cezmi A. Akdiş
Sena Ardıçlı,
Yasutaka Mitamura,
Cezmi A. Akdiş
Mübeccel Akdiş,
Cezmi A. Akdiş
Cezmi A. Akdiş
İsmail Öğülür,
Mübeccel Akdiş,
Mübeccel Akdiş,
Mübeccel Akdiş,
Cezmi A. Akdiş
İsmail Öğülür,
İsmail Öğülür,
İsmail Öğülür,
Yasutaka Mitamura,
Cezmi A. Akdiş
Yasutaka Mitamura,
Cezmi A. Akdiş
Cezmi A. Akdiş
Mübeccel Akdiş,
Cezmi A. Akdiş
Cezmi A. Akdiş
Cezmi A. Akdiş
Cezmi A. Akdiş
Cezmi A. Akdiş
Mübeccel Akdiş,
Cezmi A. Akdiş
Summary
This review explains how everyday substances including microplastics, air pollutants, food additives, and household chemicals damage the protective lining of our body's surfaces (epithelial barriers). Even trace amounts of these substances can cause the barriers to become leaky, allowing bacteria and allergens to trigger chronic inflammation. The research suggests that microplastic exposure, alongside other modern pollutants, may be contributing to the rise in chronic inflammatory diseases over the past several decades.
The prevalence of many chronic noncommunicable diseases has been steadily rising over the past six decades. During this time, humans have been increasingly exposed to substances toxic for epithelial cells, including air pollutants, laundry and dishwashers, household chemicals, toothpaste, food additives, microplastics, and nanoparticles, introduced into our daily lives as part of industrialization, urbanization, and modernization. These substances disrupt the epithelial barriers and lead to microbial dysbiosis and cause immune response to allergens, opportunistic pathogens, bacterial toxins, and autoantigens followed by chronic inflammation due to epigenetic mechanisms. Recent evidence from studies on the mechanisms of epithelial barrier damage has demonstrated that even trace amounts of toxic substances can damage epithelial barriers and induce tissue inflammation. Further research in this field is essential for our understanding of the causal substances and molecular mechanisms involved in the initiation of leaky epithelial barriers that cascade into chronic inflammatory diseases.