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61,005 resultsShowing papers similar to Toxicity Study and Quantitative Evaluation of Polyethylene Microplastics in ICR Mice
ClearDistribution and Tissue Damage After a Single Microplastic Exposure in Mice
Researchers administered fluorescent microplastics to mice by oral gavage and tracked their distribution through the body over several hours. They found direct evidence of microplastic particles in the blood, lungs, brain, kidneys, liver, and spleen, with fluorescence peaking at two hours after exposure. Histological examination revealed mild tissue damage including congestion in the liver and lungs, providing evidence that ingested microplastics can enter the bloodstream and reach multiple organs.
Organ-specific accumulation and toxicity analysis of orally administered polyethylene terephthalate microplastics
When mice were fed tiny PET plastic particles (the kind found in water bottles and food containers), the particles accumulated mainly in the lungs and caused inflammatory damage at higher doses. The study found that male mice were more sensitive than females, and the results highlight that microplastics swallowed through food and drink can travel to and harm organs beyond the digestive system.
Biodistribution and toxicity analysis of polystyrene nanoplastics in mice based on Raman detection
Researchers used surface-enhanced Raman spectroscopy with an optimized gold-silver nanorod substrate to detect and track 20 nm, 100 nm, and 1000 nm polystyrene nanoplastics in mouse lungs, demonstrating accurate biodistribution mapping down to 0.01 mg/mL concentration.
In vivo toxicity assessment of microplastics in Balb/C mice : study of inhalation exposure and its inflammatory effects
Researchers examined the in vivo toxicity of inhaled microplastics in Balb/C mice, studying pulmonary inflammation, oxidative stress, and systemic effects following repeated inhalation exposure. The study found dose-dependent lung inflammation and evidence of particle translocation to other organs.
Potential Impact Microplastic Polyethylene Terephthalate on Mice
Researchers studied how polyethylene terephthalate (PET) microplastics affect mice when ingested, tracking where the particles end up in the body. They found that microplastics accumulated in various organs and caused measurable biological effects. The study adds to growing evidence that common plastic types found in food packaging may pose health risks when consumed.
Pulmonary accumulation and immune modulation by intravenously administered environmentally relevant microplastics in mice
Researchers intravenously administered environmentally relevant oxidized polyethylene microplastics to mice and tracked their distribution using fluorescent labeling. The particles primarily accumulated in the lungs and induced inflammatory cell infiltration, demonstrating that microplastics entering the bloodstream can concentrate in pulmonary tissue and trigger immune responses.
Unraveling the in vivo fate of inhaled micro- and nanoplastics with PET imaging
Using advanced PET imaging, researchers tracked what happens to inhaled and injected micro and nanoplastics inside living mice for the first time. They found that nanoplastics largely avoided being captured by immune cells in the lungs and could travel to other organs, while both sizes accumulated heavily in the liver and spleen after entering the bloodstream. This study provides direct evidence that inhaled plastic particles can redistribute throughout the body, which is important for understanding how airborne microplastics might affect human health.
Distribution and toxicity of submicron plastic particles in mice
Researchers found that orally administered submicron-sized microplastics distributed to multiple organs and biofluids in mice over four weeks, causing oxidative stress and inflammation in tissues including the liver, kidneys, and gut.
Chronic lung tissue deposition of inhaled polyethylene microplastics may lead to fibrotic lesions
In a mouse study, inhaled polyethylene microplastics accumulated in lung tissue over 90 days of repeated exposure, causing chronic inflammation, immune changes, and early signs of lung scarring (fibrosis). Even at the lowest doses, the microplastics triggered inflammatory cell buildup and thickening of lung walls. These findings suggest that long-term breathing of airborne microplastics could lead to permanent lung damage, which is concerning given rising levels of plastic particles in indoor and outdoor air.
Comparison of PET tracing and biodistribution between 64Cu-labeled micro-and nano-polystyrene in a murine inhalation model
Using advanced PET imaging in mice, researchers tracked where inhaled micro and nanoplastics traveled in the body and found that nano-sized particles cleared from the lungs much faster than micro-sized ones but accumulated more in the liver, spleen, and other organs. Micro-sized particles stayed in the lungs longer, with peak retention at 24 hours, while nano-sized particles spread quickly throughout the body. This is one of the first studies to directly visualize how inhaled plastic particles distribute through living mammals, confirming that smaller particles pose a greater risk of reaching organs beyond the lungs.
Size-Dependent Pulmonary Toxicity and Whole-Body Distribution of Inhaled Micro/Nanoplastic Particles in Male Mice from Chronic Exposure
Researchers exposed mice to airborne micro- and nanoplastic particles through normal breathing over an extended period and found the highest accumulation in the lungs, followed by the blood and spleen. Surprisingly, the larger 1-micrometer microplastics caused more severe lung damage than the smaller 80-nanometer particles, triggering inflammation, cell death, and scarring. These findings highlight that breathing in airborne plastic particles poses real health risks, with particle size playing an important role in the type of damage caused.
Deleterious effects of microplastics and nanoplastics on rodent lungs: a systematic review
This systematic review summarizes research on how inhaled micro- and nanoplastics affect the lungs in animal studies. The findings show these particles can cause lung inflammation, tissue damage, and immune responses, suggesting that breathing in airborne microplastics may pose real risks to respiratory health.
In Vivo Tissue Distribution of Microplastics and the Systemic Metabolic Changes After Gastrointestinal Exposure in Mice
Mice exposed to microplastics via the gastrointestinal route showed systemic distribution of particles to multiple organs and measurable changes in metabolic pathways, providing early in vivo evidence of systemic impacts from plastic ingestion.
Impacts of polypropylene microplastics on lipid profiles of mouse liver uncovered by lipidomics analysis and Raman spectroscopy
Researchers found that polypropylene microplastics accumulated in mouse liver tissue and caused significant changes to lipid metabolism, even without obvious outward health symptoms. Advanced analysis revealed altered fat profiles and lipid droplet buildup in the liver. This study suggests that microplastic exposure could quietly disrupt liver fat processing, which is relevant to understanding long-term metabolic health effects in mammals.
In Vivo Tissue Distribution of Microplastics and Systemic Metabolomic Alterations After Gastrointestinal Exposure
Researchers fed mice a mixture of common microplastics and then tracked where the particles ended up in the body and how they affected metabolism. They found that ingested microplastics crossed the gut barrier and accumulated in the liver, kidneys, and other tissues, causing measurable changes in metabolic pathways. The study provides evidence that microplastic exposure through the digestive system can lead to widespread tissue distribution and systemic metabolic disruption in mammals.
Correlative spectroscopy and microscopy analysis of micro- and nanoplastics in complex biological matrices
Researchers combined fluorescence microscopy, second harmonic generation imaging, and coherent Raman scattering to detect and map micro- and nanoplastics in lung cells, zebrafish, and mouse tissues. Polystyrene nanoplastics were found to cross the blood-brain barrier and accumulate in lipid-rich brain regions in animal models.
Size-Dependent PulmonaryToxicity and Whole-Body Distributionof Inhaled Micro/Nanoplastic Particles in Male Mice from Chronic Exposure
Researchers used a whole-body inhalation exposure system to chronically expose male mice to polystyrene micro- and nanoplastics at environmental concentrations and tracked particle distribution and lung toxicity. Nanoplastics (80 nm) showed greater tissue transport than microplastics (1 µm), with highest accumulation in lungs followed by blood and spleen, and both sizes disrupted oxidative balance and antioxidant defenses.
Lung retention, distribution and persistence of polymer particles in rats exposed via inhalation
Researchers studied the fate of inhaled polymer particles in rats by exposing them to polystyrene and polyamide aerosols for 28 days. The study found that both types of particles accumulated in the lungs and migrated to lung-draining lymph nodes, but were not detected in the liver, spleen, or kidneys. The particles persisted in lung tissue for weeks after exposure ended, raising questions about the long-term bioavailability and fate of inhaled microplastics.
Mass Balance Tracing of In Vivo Biodistribution, Relocation, and Excretion of Europium-Doped Micro/Nanoplastics in Rats
Scientists injected tiny plastic particles into rats and tracked where they went in the body for three months. Most plastic particles collected in the liver and spleen, with smaller particles being harder for the body to get rid of—only 80% of the smallest particles were eliminated compared to just 15% of larger ones. This suggests that microplastics from food, water, and air could build up in our organs over time, though the long-term health effects are still unknown.
Correlative spectroscopy and microscopy analysis of micro- and nanoplastics in complex biological matrices
Researchers combined fluorescence, second harmonic generation, and coherent Raman scattering microscopy in a single instrument to image micro- and nanoplastics in lung cells, zebrafish, and mouse tissues. Polystyrene nanoplastics crossed the blood-brain barrier and accumulated in lipid-rich brain regions in mouse models.
Toxicity and Biodistribution of Fragmented Polypropylene Microplastics in ICR Mice
Researchers fed mice two different sizes of polypropylene microplastics and found no significant toxic effects in standard toxicological assessments, including body weight, organ weight, and tissue examination. They established that the no-observed-adverse-effect level was at or above 2,000 milligrams per kilogram of body weight. Using fluorescently labeled particles, the team tracked the distribution of microplastics in real time, finding that the particles spread to multiple organs including the brain.
Lung retention, distribution and persistence of polymer particles in rats exposed via inhalation
Researchers studied the fate of inhaled polymer particles in rats by exposing them to polystyrene and polyamide aerosols for 28 days. The study found that both types of particles accumulated in the lungs and migrated to lung-draining lymph nodes, but were not detected in the liver, spleen, or kidneys. The particles persisted in lung tissue for weeks after exposure ended, highlighting potential concerns about long-term retention of inhaled microplastics.
MicroRaman spectroscopy detects the presence of microplastics in human urine and kidney tissue
Scientists confirmed for the first time that microplastics accumulate in human kidney tissue, finding 26 plastic particles in kidney and urine samples using advanced spectroscopy. The most common plastics found were polyethylene and polystyrene, with particles ranging from 1 to 29 micrometers in kidneys, providing the first direct evidence that microplastics can deposit in human kidneys.
MRI-based microplastic tracking in vivo and targeted toxicity analysis
Researchers developed a new MRI-based method to track microplastics inside living mice over 21 days. They found that the liver was the primary organ where polystyrene microplastics accumulated, and this accumulation led to liver cell death, inflammation, and changes in enzyme levels. This tracking technique could help scientists better understand how microplastics move through and affect biological systems.