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61,005 resultsShowing papers similar to Detection of Microplastics in Patients with Colorectal Adenocarcinoma using Various Techniques
ClearThe clinical relevance of microplastic exposure on colorectal cancer: A systematic review
This systematic review of four studies found that microplastic accumulation in colorectal cancer tissue (25.9-32.2 particles/g) was significantly higher than in healthy controls, with polyamide, polycarbonate, and polypropylene as the most common polymers detected. While a causal relationship has not been established, the evidence points to microplastics as a potential environmental factor in colorectal cancer development.
Microplastics and Colorectal Cancer: Presence in Human Colorectal Tissues and Associations with Tumor Biology- A Systematic Review
This review of 13 studies found that tiny plastic particles called microplastics are present in human colon tissues, with higher amounts found in cancerous tumors compared to healthy tissue. The research suggests these plastic particles may contribute to colon cancer development by causing inflammation and creating conditions that help tumors grow. While more research is needed to prove a direct cause-and-effect relationship, this highlights growing concerns about how plastic pollution in our environment and food supply might affect human health.
Identification and analysis of microplastics in peritumoral and tumor tissues of colorectal cancer
Researchers examined tumor and surrounding tissue from colorectal cancer patients and found a diverse range of microplastics, including PVC and polyethylene, with tumor tissues containing a greater variety and higher distribution of microplastics than adjacent healthy tissue. A protein called clathrin that helps cells absorb materials was highly active in the cancer tissue, suggesting it may facilitate microplastic uptake and pointing to a potential link between microplastic exposure and colorectal cancer development.
Comparative Analysis of Microplastics Detected in Human Colorectal Cancer Tissues from Two Countries
Researchers compared the physical and chemical characteristics of microplastics found in colorectal cancer tissue samples from patients in the United States and Malaysia. Using scanning electron microscopy and Fourier transform infrared spectroscopy, they identified differences in the types and properties of microplastics between the two countries. The study provides early comparative evidence that microplastics are present in human tumor tissues across different populations.
Comparative Analysis of Physical and Polymer Characteristics of Microplastics Detected in Human Colorectal Cancer Samples From the United States and Malaysia
Researchers compared the physical and chemical characteristics of microplastics found in colorectal cancer tissue samples from patients in the United States and Malaysia. Microplastics were detected in samples from both populations, with some similarities in polymer types but also distinct differences in particle size and shape between the two groups. The study adds to growing evidence that microplastics accumulate in human tissues, though more research is needed to understand any potential health implications.
Microplastics and the Rising Tide of Early‐Onset Colorectal Cancer: Exploring the Environmental Gut Connection
This paper explores the potential connection between microplastic exposure and the rising rates of early-onset colorectal cancer. The study discusses how microplastics may interact with the gut environment, suggesting that further research is needed to understand whether environmental microplastic contamination could be contributing to this emerging health trend.
Effects of microplastics on chemo-resistance and tumorigenesis of colorectal cancer
For the first time, researchers confirmed the presence of microplastics in human colorectal cancer tissue and showed in animal models that microplastics increased cancer rates and made tumors more resistant to chemotherapy drugs. The study found that microplastics trigger a cell survival mechanism called autophagy that helps cancer cells resist treatment, suggesting plastic pollution could complicate cancer outcomes.
Detection and analysis of microplastics in tissues and blood of human cervical cancer patients
In the first study of its kind, researchers detected 13 types of microplastics in the blood, tumor tissue, and surrounding tissue of cervical cancer patients using Raman spectroscopy. Microplastic levels were higher in cancerous tissue than in nearby healthy tissue, and factors like age, BMI, and bottled water consumption correlated with greater microplastic abundance, suggesting a possible link between plastic exposure and reproductive health.
Detection of microplastics in human colectomy specimens
Researchers examined tissue samples from patients who had colon surgery and detected microplastics in the specimens. The findings suggest that microplastics are commonly present in the human colon, adding to a growing body of evidence that these particles accumulate in the human digestive system.
Associations between microplastics in human feces and colorectal cancer risk
In a study of 258 colorectal cancer patients and 493 healthy controls, researchers found significantly higher levels of microplastics in the stool of cancer patients, with those in the highest exposure group having 11 times the odds of colorectal cancer. This is one of the first studies in humans to provide epidemiological evidence of a potential link between microplastic exposure and cancer risk, though more research is needed to determine if the relationship is causal.
Detection and quantification of microplastics in various types of human tumor tissues
Researchers detected microplastics in 43% of tumor samples across lung, gastric, colorectal, cervical, and pancreatic cancers, with polystyrene, PVC, and polyethylene being the types found. In pancreatic tumors, microplastic presence was associated with fewer immune cells that fight cancer and more immune cells linked to tumor progression, suggesting microplastics may create conditions that help tumors evade the immune system.
Orally Ingested Micro- and Nano-Plastics: A Hidden Driver of Inflammatory Bowel Disease and Colorectal Cancer.
This review synthesizes evidence linking ingested micro- and nano-plastics to inflammatory bowel disease and colorectal cancer risk, proposing that microplastics act as a hidden driver of gut inflammation in vulnerable populations. The authors argue that intestinal accumulation of microplastics triggers immune and oxidative stress pathways that contribute to disease progression.
From Exposure to Oncogenesis: the Role of Microplastics and Associated Pollutants in Cancer - a Literature Review
This literature review examined the growing evidence linking microplastic exposure to cancer development. Microplastics have been found in human lung, liver, and colon tissue, and research suggests they may promote cancer through chronic inflammation, oxidative stress, and by carrying known carcinogens like heavy metals and persistent organic pollutants into the body.
Microplastic accumulation in endometrial cancer tissues and its metabolic impact
Researchers examined microplastic levels in endometrial cancer tissues compared to normal tissue and found that cancer tissues contained significantly higher concentrations of plastic particles. The most common plastics detected were polyethylene, polypropylene, and polystyrene. Metabolic analysis revealed that microplastic presence was associated with changes in cancer-related metabolic pathways, suggesting that microplastics may play a role in promoting tumor development through metabolic reprogramming.
Invisible invaders: unveiling the carcinogenic threat of microplastics and nanoplastics in colorectal cancer-a systematic review
This systematic review examines the potential link between microplastics and nanoplastics and colorectal cancer. The research highlights how these tiny particles may contribute to cancer development through mechanisms like chronic inflammation and cellular damage in the gut. While more studies are needed, the findings raise important questions about the long-term consequences of ingesting plastic particles.
Could Microplastics Be a Driver for Early Onset Colorectal Cancer?
This paper explores whether microplastics could be contributing to the rising rates of colorectal cancer in people under 50. The timing of this increase lines up with the mass production of plastics starting in the 1950s, and microplastics are known to disrupt the gut lining and interact with gut bacteria in ways that could promote cancer. While not proven, the authors argue this connection deserves urgent research given how much plastic humans now ingest.
Image 2_Invisible invaders: unveiling the carcinogenic threat of microplastics and nanoplastics in colorectal cancer-a systematic review.png
This systematic review examines the potential link between microplastics and colorectal cancer. It found that humans ingest over 70,000 microplastic particles annually, and that higher concentrations of micro- and nanoplastics have been observed in colorectal tumor tissues compared to healthy tissue, suggesting a possible connection worth further investigation.
Image 1_Invisible invaders: unveiling the carcinogenic threat of microplastics and nanoplastics in colorectal cancer-a systematic review.png
This systematic review examines the potential link between microplastics and colorectal cancer. It found that humans ingest over 70,000 microplastic particles annually, and that higher concentrations of micro- and nanoplastics have been observed in colorectal tumor tissues compared to healthy tissue, suggesting a possible connection worth further investigation.
Characterization of Microplastics in Human Gastric Cancer and Control Tissues and Analysis of Associated Genetic Features
Researchers detected and characterized microplastics in human gastric cancer tissue and adjacent healthy tissue, finding significantly higher microplastic concentrations in cancer tissue, and used transcriptome sequencing to explore potential molecular mechanisms linking microplastic exposure to gastric cancer development.
Microplastics as emerging carcinogens: from environmental pollutants to oncogenic drivers
This review examines growing evidence that microplastics and nanoplastics may play a role in cancer development, with these particles found in human tumor tissues from the lungs, colon, stomach, breast, and other organs. The particles appear to promote cancer through chronic inflammation, oxidative stress, DNA damage, and disruption of key cancer-related signaling pathways. While direct proof of causation in humans is still lacking, the accumulating evidence from lab studies, animal experiments, and human tissue analysis suggests microplastics deserve serious attention as potential contributors to cancer risk.
Image 3_Invisible invaders: unveiling the carcinogenic threat of microplastics and nanoplastics in colorectal cancer-a systematic review.png
This systematic review examines the potential link between microplastics and colorectal cancer. It found that humans ingest over 70,000 microplastic particles annually, and that higher concentrations of micro- and nanoplastics have been observed in colorectal tumor tissues compared to healthy tissue, suggesting a possible connection worth further investigation.
Microplastic Exposure and Its Dual Impact on Metabolic Syndrome and Pathways of Colorectal Carcinogenesis: A Systematic Review of Epidemiological, Experimental, and Mechanistic Evidence
This systematic review examines evidence linking microplastic exposure to both metabolic syndrome and colorectal cancer pathways. It found a biologically plausible connection between microplastic exposure and these conditions, though a direct clinical link to cancer has not yet been established.
Identification and analysis of microplastics in human penile cancer tissues
Researchers found microplastics in tissue samples from patients with penile cancer, with the most common types being polyethylene, polypropylene, and PVC. Cancerous tissue contained significantly more microplastics and a greater variety of plastic types than nearby healthy tissue, suggesting a possible link between microplastic accumulation and cancer development that needs further investigation.
Ingestion of a human-relevant mixture of environmentally sourced microplastics promotes inflammation and tumorigenesis in the mouse colon
Researchers exposed mice to a realistic mixture of environmentally sourced microplastics composed of the four most common polymer types and studied the effects on the colon. They found that ingestion of this mixture promoted inflammation and enhanced tumor development in the mouse colon. The study suggests that exposure to environmentally relevant microplastic mixtures may have implications for colorectal health that warrant further investigation.