We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
61,005 resultsShowing papers similar to Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity
ClearThe quest for nanoparticle-powered vaccines in cancer immunotherapy
This review explores how nanoparticles are being developed as cancer vaccine delivery systems to train the immune system to fight tumors more effectively. While focused on cancer immunotherapy rather than microplastics, the research highlights that understanding how nanoparticles interact with the immune system is crucial -- the same principles apply to understanding how nanoplastics may affect immune responses in the body.
Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance
This review explores how nanotechnology is being used to overcome drug resistance in cancer treatment, using materials like carbon nanotubes, dendrimers, and liposomes to deliver drugs more precisely to tumors. While not directly about microplastics, the nanomaterial strategies discussed share relevance with understanding how nano-sized plastic particles interact with human cells and tissues.
Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment
This review covers advances in targeted drug delivery using nanotechnology, including nanoparticles and liposomes designed to release medications precisely where needed in the body. While focused on cancer treatment, the drug delivery technologies discussed are relevant to understanding how nanoscale plastic particles may also travel through the body and accumulate in specific tissues.
Novel application of microparticles demonstrate myeloid uptake and induce phenotypic change within the brain tumor microenvironment 2254
Researchers demonstrated that microparticles can be taken up by myeloid cells within glioblastoma tumors and can induce phenotypic changes in tumor-associated macrophages and neutrophils, suggesting that particle-based approaches may be able to modify the immunosuppressive tumor microenvironment.
Biomembrane-wrapped gene delivery nanoparticles for cancer therapy
This review examined biomembrane-wrapped nanoparticles as gene delivery vehicles for cancer therapy, highlighting how cell membrane coatings improve targeting, immune evasion, and therapeutic efficacy compared to conventional synthetic delivery systems.
Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy
Researchers reviewed how engineering the protein corona — the layer of proteins that coats nanoparticles in biological fluids — through modifications like PEGylation and protein pre-coating can improve nanoparticle targeting for cancer drug delivery by controlling how immune cells recognize and clear the particles.
Nanomaterials in Drug Delivery: Strengths and Opportunities in Medicine
This review covers how nanomaterials are being used to improve drug delivery for treating cancer and infections, offering better targeted therapy with fewer side effects. While not directly about microplastics, the research on how nanoparticles interact with human tissues provides insight into how similarly sized nanoplastics might behave once inside the body.
Reversing the immunosuppressive microenvironment with reduced redox level by microwave-chemo-immunostimulant Ce–Mn MOF for improved immunotherapy
Researchers developed a nanoparticle-based treatment that combines microwave energy, chemotherapy, and immune activation to reverse the protective environment that tumors create to hide from the immune system. In animal experiments, this combined approach significantly increased immune cell infiltration into tumors and improved the body's ability to fight cancer beyond the treated area.
How to Treat Melanoma? The Current Status of Innovative Nanotechnological Strategies and the Role of Minimally Invasive Approaches like PTT and PDT
This review summarizes advances in nanotechnology-based treatments for melanoma, including photothermal and photodynamic therapies using engineered nanoparticles as drug carriers and light absorbents. While nanoparticle-based therapies show promise for improving treatment outcomes, the environmental fate of these engineered nanomaterials remains a concern, as nanoparticles can behave similarly to microplastics when released into ecosystems.
Morphological and lipid metabolism alterations in macrophages exposed to model environmental nanoplastics traced by high-resolution synchrotron techniques
Researchers used advanced imaging techniques to study how nanoplastics affect immune cells called macrophages and found that the particles caused significant changes in cell shape and disrupted fat metabolism. The nanoplastics accumulated inside the cells and altered the composition and distribution of lipids, which are essential for normal immune function. The findings suggest that nanoplastic exposure may impair the immune system by interfering with how immune cells process and store fats.
Polystyrene nanoplastics dysregulate lipid metabolism in murine macrophages in vitro
Researchers investigated the effects of polystyrene nanoplastics on immune cell metabolism and found that macrophages exposed to nanoplastics transformed into lipid-laden foam cells. The study suggests that nanoplastic exposure dysregulates lipid metabolism in immune cells, with implications for understanding how these particles may interact with the immune system at the cellular level.
Intratumoural microbiota: from theory to clinical application
Researchers reviewed how bacteria living inside tumors — called intratumoural microbiota — influence cancer development, immune responses, and treatment outcomes. They highlight that while some tumor-resident microbes drive cancer progression by damaging DNA and disrupting immune signaling, engineered bacteria could be harnessed as novel therapeutic tools to target tumors directly.
Exploring Metal Nanoparticles Interaction with Cancer Cells
This paper is not relevant to microplastics research — it reviews the uses of metal nanoparticles in biomedical applications, particularly cancer treatment, and discusses their toxicity profiles.
Cellular mechanisms of microplastic and nanoparticle exposure and its relationship with metabolic diseases: Literature review
This literature review examined how microplastic and nanoparticle exposure affects cellular mechanisms related to metabolic disease, finding evidence that these contaminants disrupt insulin signaling, alter lipid metabolism, and may contribute to the development of metabolic syndrome.
Effects of food contact material-related nanoplastics on 3T3-L1 cell uptake and lipid metabolism
Researchers examined the uptake of food contact material-derived nanoplastics into 3T3-L1 adipocyte cells and assessed subsequent effects on lipid metabolism. The study investigated how nanoplastics that migrate from packaging into food may disrupt fat storage and metabolic signaling at the cellular level.
Could Nanotechnology Help to End the Fight Against COVID-19? Review of Current Findings, Challenges and Future Perspectives
This review assessed the potential role of nanotechnology in combating COVID-19, covering nano-enabled diagnostics, drug delivery systems, and vaccines, while noting that most applications were still in early development stages and faced significant regulatory and safety challenges.
Lipidome is lipids regulator in gastrointestinal tract and it is a life collar in COVID-19: A review
This review examined the lipidome as a regulator of lipid metabolism in the gastrointestinal tract and proposed that lipid-protein interactions and lipoprotein transport pathways may play a protective role during COVID-19, with implications for understanding disease severity in metabolically vulnerable individuals.
The Influence of Supplementation with Zinc in Micro and Nano Forms on the Metabolism of Fatty Acids in Livers of Rats with Breast Cancer.
This study investigated the effects of zinc nano- and microparticles as dietary supplements on fatty acid metabolism in rats with breast cancer. This pharmacology study focuses on zinc supplementation and cancer biochemistry, with no direct relevance to environmental microplastics.
The ancillary effects of nanoparticles and their implications for nanomedicine
Researchers reviewed 'ancillary effects' — the unintended biological interactions between nanoparticles and living systems that occur independent of engineered targeting or therapeutic functions — cataloguing how nanomaterial surface properties can modulate cell signaling, immune responses, and toxicity in ways that have major implications for nanomedicine safety and design.
Converging frontiers in cancer treatment: the role of nanomaterials, mesenchymal stem cells, and microbial agents—challenges and limitations
This review examines three cutting-edge approaches to cancer treatment: nanomaterials for targeted drug delivery, mesenchymal stem cells as carriers for therapeutic agents, and microbial agents that can selectively attack tumors. Each approach aims to overcome the limitations of conventional treatments like chemotherapy and radiation, which often damage healthy tissue and lead to drug resistance. The authors discuss both the promise and the remaining challenges of bringing these innovative therapies into clinical practice.
An Overview of Nanoparticle Properties and Their Bioactivity
This systematic review summarized the properties and bioactivity of nanoparticles (1-100 nm), covering how their size, shape, and surface characteristics influence their behavior in biological systems and their potential applications in microbiology.
Redox Regulation of Immunometabolism in Microglia Underpinning Diabetic Retinopathy
This review examines how redox regulation of immunometabolism in retinal microglia contributes to diabetic retinopathy progression. The study discusses how microglial activation involves tightly regulated metabolic reprogramming, and explores potential therapeutic targets within redox signaling pathways.
Tumorigenic and tumoricidal properties of exosomes in cancers; a forward look
This review explores how tiny cell-released vesicles called exosomes can either promote or fight cancer by transferring signaling molecules between cells. While not directly about microplastics, the research is relevant because nanoplastics are similar in size to exosomes and may interfere with these important cell communication pathways. Understanding how nanoscale particles affect cell signaling could help explain some of the biological effects of nanoplastic exposure.
Exposure to polystyrene nanoplastics impairs lipid metabolism in human and murine macrophages in vitro
Researchers exposed human and mouse macrophages to polystyrene nanoplastics and found that the particles disrupted lipid metabolism in these immune cells. The study observed that nanoplastic exposure altered how macrophages process and store fats, which could affect their ability to function properly. These findings suggest that nanoplastic accumulation in immune cells may interfere with normal metabolic processes at the cellular level.