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20 resultsShowing papers similar to Toxicological impacts of nanopolystyrene on zebrafish oocyte with insight into the mechanism of action: An expression-based analysis
ClearPolystyrene Nanoplastic Exposure Induces Developmental Toxicity by Activating the Oxidative Stress Response and Base Excision Repair Pathway in Zebrafish (Danio rerio)
Researchers exposed zebrafish embryos to polystyrene nanoplastics at various concentrations and found significant developmental abnormalities including reduced hatching rates and increased malformations. The nanoplastics activated oxidative stress responses and DNA repair pathways, indicating cellular damage during critical early development stages. The study provides mechanistic evidence for how nanoplastic exposure can disrupt normal embryonic development in aquatic organisms.
Molecular effects of polystyrene nanoplastics toxicity in zebrafish embryos (Danio rerio)
Researchers exposed zebrafish embryos to polystyrene nanoplastics at various concentrations and measured gene expression changes related to stress, inflammation, and DNA repair. They found dose-dependent activation of oxidative stress and apoptotic pathways at the highest concentration, along with inhibition of the neurotransmitter-related gene acetylcholinesterase and DNA repair genes. The study suggests that nanoplastic exposure at the molecular level may compromise cellular defense mechanisms and neurological function in developing fish.
Impact of polystyrene nanoplastics on apoptosis and inflammation in zebrafish larvae: Insights from reactive oxygen species perspective
Researchers showed that polystyrene nanoplastics accumulate in zebrafish larvae and trigger excessive reactive oxygen species production via NADPH oxidase upregulation, causing mitochondrial dysfunction, apoptosis, and NF-κB-driven inflammation — with inhibiting ROS generation effectively blocking downstream cell death and inflammatory responses.
Polystyrene nanoplastics cause developmental abnormalities, oxidative damage and immune toxicity in early zebrafish development
Zebrafish embryos exposed to polystyrene nanoplastics showed dose-dependent developmental problems including delayed hatching, reduced survival, smaller body size, and the nanoplastics accumulated in critical organs like the eyes, heart, liver, and brain. The particles triggered oxidative stress that damaged cells and activated inflammatory immune responses, demonstrating how nanoplastic contamination in water can cause widespread harm to developing organisms.
From mothers to offspring: Polystyrene nanoplastics create a hidden toxic legacy via mitochondrial dysfunction
Researchers exposed female zebrafish to polystyrene nanoplastics before mating with unexposed males and found that maternal exposure at 100 μg/L reduced offspring hatching success and caused developmental defects in the F1 generation raised in clean water, demonstrating transgenerational toxicity via mitochondrial dysfunction.
Female zebrafish (Danio rerio) exposure to polystyrene nanoplastics induces reproductive toxicity in mother and their offspring
Researchers exposed female zebrafish to polystyrene nanoplastics for six weeks and found the particles disrupted sex hormone levels and oocyte development, reducing egg production in the exposed generation and carrying endocrine disruption effects into unexposed offspring through the hypothalamic-pituitary-gonadal axis.
The mechanism of polystyrene nanoplastics hepatotoxicity in zebrafish (Danio rerio)
This study investigated the hepatotoxic mechanisms of polystyrene nanoplastics in zebrafish (Danio rerio), finding that nanoplastics accumulating in the liver triggered oxidative stress and cellular injury pathways. The results highlight nanoplastics as a significant liver toxicant in aquatic vertebrates.
Nanoplastic contamination: Impact on zebrafish liver metabolism and implications for aquatic environmental health
Zebrafish exposed to polystyrene nanoparticles for 28 days showed significant disruptions in liver metabolism, including altered fat processing, signs of inflammation, oxidative stress, and DNA damage. Notably, at lower doses the liver's detox enzymes appeared to break down the nanoplastics themselves, while higher doses overwhelmed these defenses and caused more severe injury.
Transcriptome sequencing and metabolite analysis reveal the toxic effects of nanoplastics on tilapia after exposure to polystyrene
Researchers exposed larval tilapia to polystyrene nanoplastics and then analyzed changes in gene expression and metabolic profiles after a recovery period. They found that nanoplastic exposure disrupted immune-related pathways, energy metabolism, and lipid processing in the fish, with some effects persisting even after exposure ended. The study suggests that nanoplastics can cause lasting metabolic and immune disruptions in freshwater fish.
Exposure to polystyrene microplastics induced gene modulated biological responses in zebrafish (Danio rerio)
Researchers exposed zebrafish to polystyrene microplastics and analyzed changes in gene expression related to immune response, oxidative stress, and endocrine function. They found that microplastic exposure modulated genes involved in inflammation and detoxification pathways, indicating biological stress at the molecular level. The study provides evidence that microplastics can trigger gene-level disruptions in fish even before visible physical symptoms appear.
Maternal polystyrene nanoplastics suppress zebrafish offspring development and locomotion through mitochondrial dysfunction
Researchers found that zebrafish mothers exposed to nanoplastics at environmentally relevant concentrations passed developmental harm to offspring, with transcriptomic analysis pointing to suppressed oxidative phosphorylation genes as the mechanism — showing nanoplastics can impair embryo energy metabolism across generations even when offspring are not directly exposed.
Adverse adult-onset and multigenerational effects in zebrafish (Danio rerio) developmentally exposed to polystyrene nanoplastics
Researchers raised zebrafish exposed to nanoplastics during early development through to adulthood and found lasting reproductive impairment, heritable hyperactivity in offspring, and molecular changes in male reproductive and brain tissue linked to neurodegenerative disease pathways and endocrine disruption, demonstrating that brief developmental nanoplastic exposure can cause multigenerational harm.
Polystyrene nanospheres-induced hepatotoxicity in swamp eel (Monopterus albus): From biochemical, pathological and transcriptomic perspectives
Researchers exposed swamp eels to polystyrene nanoplastics for 28 days and found significant liver damage including oxidative stress, tissue abnormalities, and disrupted gene expression related to immune response and metabolism. Higher concentrations caused more severe liver injury, with changes detectable at both the biochemical and genetic levels. This study adds evidence that nanoplastic exposure can harm liver function in freshwater species important to aquaculture and local food supplies.
Effects of polystyrene nanoplastic size on zebrafish embryo development
Researchers exposed zebrafish embryos to polystyrene nanoplastics of four sizes and found only the smallest (30 nm) caused mortality and altered oxidative stress and apoptosis gene expression, while larger particles (100–450 nm) were ingested and accumulated in the digestive system without causing developmental malformations.
Polystyrene nanoplastics cause reproductive toxicity in zebrafish: PPAR mediated lipid metabolism disorder
Zebrafish exposed to polystyrene nanoplastics at environmentally realistic levels experienced delayed sperm development, abnormal egg growth, and impaired reproduction, with larger 500-nanometer particles causing the worst effects. The reproductive damage was linked to disrupted fat metabolism in the ovaries through a specific signaling pathway, and the effects resembled polycystic ovary syndrome (PCOS) -- raising concerns about potential impacts on human fertility.
Transcriptome and Gene Family Analyses Reveal the Physiological and Immune Regulatory Mechanisms of Channa maculata Larvae in Response to Nanoplastic-Induced Oxidative Stress
Researchers exposed larvae of blotched snakehead fish to polystyrene nanoplastics at concentrations ranging from 0.05 to 20 mg/L and observed concentration-dependent damage to the liver and intestines. The nanoplastics triggered oxidative stress responses and affected genes involved in immune regulation and detoxification. The study suggests that nanoplastic pollution during early fish development could compromise both organ function and immune defenses.
Orally administered nano-polystyrene caused vitellogenin alteration and oxidative stress in the red swamp crayfish (Procambarus clarkii)
Researchers orally dosed red swamp crayfish with 100 nm carboxylated polystyrene nanoparticles and found mild but measurable stress responses including altered gene expression in immune function, oxidative stress pathways, lipid metabolism, and reproduction, suggesting nanoplastics can perturb molecular systems even at low concentrations without breaching physiological thresholds.
Toxicity of nanoplastics for zebrafish embryos, what we know and where to go next
This review integrates findings from studies on how polystyrene nanoplastics affect zebrafish embryo development, a widely used model for understanding toxicity. Researchers found that the functional coating on nanoplastic surfaces had a greater influence on toxic effects than particle size or concentration alone. The study highlights that surface chemistry is a critical and often overlooked factor in nanoplastic toxicity, and calls for more standardized study designs to improve comparability across research.
Effects of Acute Exposure to Polystyrene Nanoplastics on the Channel Catfish Larvae: Insights From Energy Metabolism and Transcriptomic Analysis
Researchers found that acute exposure to polystyrene nanoplastics disrupted energy metabolism in channel catfish larvae, with transcriptomic analysis revealing altered gene expression in pathways related to oxidative stress and metabolic processes.
Short-term polystyrene nanoplastic exposure alters zebrafish male and female germline and reproductive outcomes, unveiling pollutant-impacted molecular pathways
A short 96-hour exposure to polystyrene nanoplastics harmed both male and female reproductive cells in zebrafish. In males, nanoplastics crossed the testicular barrier, entered reproductive cells directly, and caused abnormal sperm with reduced movement. In females, the exposure disrupted egg development, suggesting that even brief nanoplastic contact could impair fertility in aquatic species and raising questions about similar risks for human reproductive health.