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61,005 resultsShowing papers similar to Developmental and reproductive toxic effects of exposure to microplastics: A review of associated signaling pathways
ClearMicroplastics: unraveling the signaling pathways involved in reproductive health
This review examines the effects of microplastics on male and female reproductive health, focusing on the metabolic pathways involved in compromised gamete quality, toxicity, apoptosis, and DNA damage. Evidence indicates that microplastics can increase oxidative stress leading to developmental abnormalities, epigenetic changes, and reduced gamete quality, though research on mammalian and human reproductive effects remains limited compared to studies in aquatic organisms.
A critical review on male-female reproductive and developmental toxicity induced by micro-plastics and nano-plastics through different signaling pathways.
This critical review examined how micro- and nanoplastics disrupt male and female reproductive systems and fetal development through multiple signaling pathways, including endocrine disruption, oxidative stress, and epigenetic modification, based on animal and cell studies.
Mechanistic insights into microplastic-induced reproductive toxicity in aquatic organisms: A comprehensive review
This review summarizes how microplastics cause reproductive harm in aquatic organisms by disrupting hormones, triggering oxidative stress, and interfering with cell death pathways. These effects lead to reduced fertility, abnormal egg and sperm development, and changes that can pass to future generations. Since microplastics accumulate through the food chain, these reproductive effects in aquatic life could have broader implications for ecosystem health and the seafood that humans consume.
Reproductive toxicity of microplastics role of oxidative stress in cellular and molecular damage
This review synthesizes in vitro, in vivo, and epidemiological evidence on how microplastics cause reproductive toxicity, focusing on oxidative stress as the central mechanism. MPs infiltrate reproductive tissues, generate reactive oxygen species, and disrupt gametogenesis, hormone regulation, and embryonic development across multiple species.
Reproductive toxicity and related mechanisms of micro(nano)plastics in terrestrial mammals: Review of current evidence.
This review of terrestrial mammal studies found that micro- and nanoplastics induce reproductive toxicity through oxidative stress, inflammation, endocrine disruption, and DNA damage, affecting both male and female fertility. In males, effects include blood-testis barrier disruption and impaired spermatogenesis, while females show compromised oocyte maturation, ovarian fibrosis, and diminished ovarian reserve, with particles also capable of crossing the maternal-fetal interface.
A meta-analysis-based adverse outcome pathway for the male reproductive toxicity induced by microplastics and nanoplastics in mammals
This meta-analysis of 39 studies mapped the adverse outcome pathway for microplastic and nanoplastic-induced male reproductive toxicity in mammals. Increased reactive oxygen species triggers a cascade of cellular damage including mitochondrial dysfunction, sperm DNA damage, and disrupted hormone signaling, ultimately leading to reduced sperm quality, impaired spermatogenesis, and decreased testosterone levels.
Effects of micro(nano)plastics on the reproductive system: A review
This review summarizes research on how micro and nanoplastics affect the reproductive system in both animal studies and cell experiments. Evidence indicates these particles can cross biological barriers, accumulate in reproductive organs, and disrupt hormones, egg development, and sperm quality. While human studies are still limited, the animal data suggests microplastic exposure may be a meaningful concern for reproductive health.
Concerning influences of micro/nano plastics on female reproductive health: focusing on cellular and molecular pathways from animal models to human studies
This review summarizes research showing that micro- and nanoplastics can harm the female reproductive system in multiple ways, from reducing ovarian reserves and disrupting hormone balance to accumulating in the placenta and breast milk. Animal studies show these particles trigger oxidative stress and inflammation in reproductive tissues, and human studies have confirmed their presence in placental tissue and infant feces, raising concerns about effects on fertility and fetal development.
Reproductive toxicity of micro- and nanoplastics
This review summarizes existing research on how micro- and nanoplastics harm reproduction across many species, from marine invertebrates to mammals. The particles can cause oxidative stress and hormone disruption, leading to reduced fertility, abnormal embryo development, and toxic effects that pass to offspring. The findings raise concerns that human reproductive health could be similarly affected given our increasing exposure to these particles.
Adverse effects of microplastics and nanoplastics on the reproductive system: A comprehensive review of fertility and potential harmful interactions
This review summarizes how microplastics and nanoplastics can harm both male and female reproductive systems by disrupting hormone signaling, damaging sperm and egg cells, and causing inflammation in reproductive tissues. Smaller nanoplastics are especially concerning because they can cross biological barriers more easily and reach the testes and ovaries. With global infertility rates rising, the authors highlight environmental plastic exposure as a factor that deserves more research attention.
Research Progress in Reproductive Toxicity of Micro- and Nanoplastics on Males and Its Mechanisms
This review summarized research on the reproductive toxicity of micro- and nanoplastics (MNPs) in males, finding that MNPs accumulate in reproductive organs and cause toxicity through oxidative stress, hormonal disruption, and DNA damage, with implications for both animal and human reproductive health.
"Unseen Dangers: The Effects of Micro- and Nanoplastics on Human Reproductive Health - A Narrative Review"
This review examines the effects of micro- and nanoplastics on human reproductive health, covering evidence from in vitro, animal, and epidemiological studies showing that plastic particles can disrupt hormone signaling, sperm function, ovarian development, and placental integrity.
Micro- and nano-plastics activation of oxidative and inflammatory adverse outcome pathways
This review maps the biological harm caused by micro- and nanoplastics to formal toxicity pathways, finding that oxidative stress is a common starting point for damage at every level from cells to whole organisms. Researchers found that in ecological settings, this oxidative damage cascades into growth inhibition and behavioral changes, while in human health contexts it may trigger inflammatory responses. The study highlights that more mammalian research is needed to fully define the health risks of plastic particle exposure.
Microplastics and impaired male reproductive health—exploring biological pathways of harm: a narrative review
This narrative review summarizes the evidence that microplastics may harm male reproductive health through oxidative stress, hormone disruption, inflammation, and direct damage to reproductive cells. While animal studies show concerning effects on sperm quality, testicular function, and fertility, human studies are still lacking. The review calls for urgent research on microplastic impacts on human male fertility and for policies to reduce microplastic exposure.
The hidden threat: Unraveling the impact of microplastics on reproductive health
This review summarizes how microplastics disrupt the reproductive system in both males and females by interfering with hormone signaling, damaging the blood-testis barrier, impairing sperm production, and causing problems in the ovaries and uterus. The authors also note that microplastic exposure may affect offspring development, including their future reproductive capacity and metabolism.
Microplastics and male reproductive system: A comprehensive review based on cellular and molecular effects
This comprehensive review examines how microplastics affect the male reproductive system at cellular and molecular levels, drawing on studies from multiple scientific databases. Researchers found that microplastics can damage testicular structure and function, impair spermatogenesis, and disrupt sperm parameters through mechanisms including oxidative stress, inflammation, and activation of cell death pathways. The review highlights that microplastics reduce ATP production and trigger signaling cascades that may contribute to male fertility problems.
The Pressing Issue of Micro- and Nanoplastic Contamination: Profiling the Reproductive Alterations Mediated by Oxidative Stress
This review examined how micro- and nanoplastics affect reproductive health across aquatic and land-based organisms, focusing on oxidative stress as the primary damage mechanism. Researchers found that these plastic particles can reach the gonads through the bloodstream and even accumulate in human and mouse placenta, with harmful effects on sperm and egg development, embryo growth, and offspring survival. The severity of reproductive harm appears to increase with smaller particle sizes and longer exposure times.
A review of the neurobehavioural, physiological, and reproductive toxicity of microplastics in fishes
This review summarizes how microplastics cause a range of harmful effects in fish, including behavioral changes, brain and immune system damage, oxidative stress, and reproductive disruption through interference with hormone signaling. These findings are relevant to human health because many of the same biological pathways affected in fish also exist in humans, and people consume fish that have accumulated microplastics.
Exploring toxicological pathways of microplastics and nanoplastics: Insights from animal and cellular models
This review examines what animal and cell studies have revealed about how microplastics and nanoplastics cause harm at the molecular level, including promoting inflammation, oxidative stress, and cell death. Most research has focused on reproductive toxicity and polystyrene particles, while effects on the gut, brain, and heart remain understudied. The authors note that many experiments use unrealistic concentrations and synthetic particles, making it difficult to apply the results to real-world human exposure.
Microplastics, Endocrine Disruptors, and Oxidative Stress: Mechanisms and Health Implications
This review examines how microplastics and nanoplastics trigger oxidative stress as a central mechanism of toxicity across multiple organ systems, including reproductive, cardiovascular, hepatic, and neurological tissues. The study highlights that these particles often carry endocrine-disrupting chemicals like bisphenol A and phthalates, which together generate reactive oxygen species, impair mitochondrial function, and compromise antioxidant defenses.
Evaluation of the health impacts and deregulation of signaling pathways in humans induced by microplastics
This review evaluates how microplastics disrupt key signaling pathways inside human cells, leading to chronic inflammation, oxidative stress, hormone disruption, and abnormal cell death. Microplastics activate inflammatory pathways like NF-kB and MAPK while interfering with the body's protective stress responses. Understanding these cellular mechanisms is important because they help explain how long-term microplastic exposure could contribute to chronic diseases in humans.
Threats of nano/microplastics to reproduction and offspring: Potential mechanisms and perspectives
This review summarized the evidence on how nano- and microplastics threaten reproduction and offspring health across multiple species, including fish, invertebrates, and mammals. The authors outlined potential mechanisms by which these plastic particles disrupt endocrine function, gonadal development, and embryonic development.
Toxicological effects of micro/nano-plastics on human reproductive health: A review
This review summarizes research on how micro- and nanoplastics affect human reproductive health in both men and women. Evidence from animal and lab studies shows that these particles can accumulate in reproductive organs, disrupt hormones, damage eggs and sperm, and cause inflammation and oxidative stress. While human studies are still limited, the growing body of evidence suggests that microplastic exposure is a potential threat to fertility that warrants further investigation.
Microplastics as Emerging Contaminants: Investigating their Potential to Alter Human Metabolic and Endocrine Systems
This review investigated the potential of microplastics to alter human hormone signaling, synthesizing evidence that plastic particles and their chemical additives can act as endocrine disruptors at environmentally relevant concentrations. The paper highlighted reproductive and metabolic pathways as areas of particular concern.