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Papers
20 resultsShowing papers similar to Multi-Omics Approach on the Ecotoxicological Assessment of Microplastics
ClearInnovative Multi-omic Strategies to Explore Micro- and Nanoplastic Effects
This conference abstract proposes a multi-omic integration framework — combining transcriptomics, proteomics, metabolomics, and lipidomics — as a more comprehensive approach to characterizing biological responses to micro- and nanoplastic exposures than single-level analyses.
Microplastics to Metabolomics: Understanding the environmental and health implications of plastic pollution
This review explores how metabolomics, a technique for analyzing small molecules in biological systems, is being used to understand how microplastic exposure affects living organisms at the biochemical level. The authors examine both targeted and untargeted metabolomics approaches that can reveal changes in metabolic pathways caused by microplastic pollution. The study suggests that metabolomics could become a powerful tool for identifying early biomarkers of microplastic-related health effects.
Ecotoxicoproteomic assessment of microplastics and plastic additives in aquatic organisms: A review
This review examines how proteomics — the large-scale study of proteins — is being applied to understand the toxic effects of microplastics and plastic additives on aquatic organisms, and how this data can feed into adverse outcome pathway frameworks for ecological risk assessment.
Assessment of biomarker-based ecotoxic effects in combating microplastic pollution - A review
This review examined the use of biomarker-based ecotoxicological approaches to assess the impacts of microplastic pollution across marine, freshwater, and terrestrial organisms. The authors argue that standardized biomarker frameworks are needed to quantify ecological harm from microplastics more effectively.
A metabolomics perspective on the effect of environmental micro and nanoplastics on living organisms: A review
This review examines how scientists use metabolomics, the study of small molecules produced by cellular processes, to understand the toxic effects of microplastics and nanoplastics on living organisms. The research shows that these plastic particles disrupt metabolism in consistent ways across species, affecting energy production, fat processing, and amino acid pathways. These shared metabolic disruptions across different organisms suggest that microplastics could cause similar metabolic problems in humans.
Omics approaches in environmental effect assessment of engineered nanomaterials and nanoplastics
This review highlights how advanced biological analysis techniques, known as omics approaches, are being used to better understand how engineered nanomaterials and nanoplastics affect living organisms at the molecular level. These methods can reveal hidden toxic effects that traditional tests might miss. The research is important for developing more accurate risk assessments of nanoplastic exposure on environmental and human health.
Microplastic toxicity: mechanisms, assessment methods, and future research directions
This review synthesizes current knowledge on microplastic toxicity mechanisms, integrating physical, chemical, and biological pathways into a unified framework. Researchers examined assessment methods across aquatic organisms, terrestrial species, and human cell models, identifying critical knowledge gaps and recommending standardized approaches for future microplastic toxicity research.
Metabolomics Approach in Environmental Studies: Methodologies, Application and Challenges
This review examines how metabolomics, the study of small molecules in biological systems, is being applied to environmental research to understand how chemical pollutants including microplastics affect organism metabolism. The study highlights metabolomics as a valuable tool for assessing the biological effects of environmental exposures at the molecular level, helping researchers identify biomarkers of pollutant exposure in both wildlife and humans.
Review: Environmental toxicology of marine microplastic pollution — R0/PR2
This review examines the toxicological impacts of microplastics on marine organisms across trophic levels — from phytoplankton to fish — finding diverse biological effects at molecular, metabolic, and physiological levels, while calling for more environmentally relevant research methods.
Metabolomics-Based Insights Into the Toxicological Effects and Mechanisms of Microplastics: A Comprehensive Review.
This review of existing research shows that microplastics—tiny plastic particles found everywhere in our environment—can harm multiple body systems including the gut, brain, and reproductive organs. Scientists used a technique called metabolomics (studying how our body processes chemicals) to discover that microplastics disrupt normal metabolism, potentially affecting everything from digestion and brain function to fertility and child development. This research helps explain why microplastic pollution may be a serious health threat that requires urgent attention and solutions.
Environmental toxicology of marine microplastic pollution
This review summarized a decade of research on the environmental toxicology of marine microplastic pollution across different ocean organisms and trophic levels. Researchers found that microplastics can accumulate in marine life from phytoplankton to fish, causing molecular, metabolic, and physiological harm. The study emphasizes that understanding these toxic effects is essential for assessing the broader ecological risks of plastic pollution in ocean environments.
A critical viewpoint on current issues, limitations, and future research needs on micro- and nanoplastic studies: From the detection to the toxicological assessment.
This critical review examines the current methods for detecting and characterizing micro- and nanoplastics in various environmental samples, as well as reported toxic effects from in vivo and in vitro studies. The authors found that while substantial effort has been made to understand microplastic behavior, the scientific community is still far from a complete understanding of how these particles behave in biological systems. The review calls for improved standardized protocols and more studies focused on uptake kinetics, accumulation, and biodistribution.
The Role of Omics Technology in Evaluating Plastic Pollution’s Effects on Plants: A Comprehensive Review
This comprehensive review examines how omics technologies (genomics, proteomics, metabolomics, transcriptomics) are being applied to understand the molecular mechanisms by which micro- and nanoplastics damage plants, including oxidative stress, stunted growth, and disrupted soil microbiomes.
Systematic Assessment of Mechanisms, Developments, Innovative Solutions, and Future Perspectives of Microplastics and Ecotoxicity – A Review
This comprehensive review summarizes current knowledge about how microplastics form, spread through the environment, and affect living organisms at every level of the food chain. It covers the toxic effects of microplastics on cells, organs, and whole organisms, including inflammation, oxidative stress, and hormone disruption. The review also evaluates emerging methods for breaking down microplastics, concluding that a combination of prevention, cleanup, and policy changes is needed to address this growing health threat.
A Review of Liquid Chromatography-Mass Spectrometry Strategies for the Analyses of Metabolomics Induced by Microplastics
This review summarized liquid chromatography-mass spectrometry strategies for analyzing metabolomic changes induced by microplastic exposure, covering analytical approaches for understanding how microplastics disrupt metabolic pathways in living organisms.
Toxicological review of micro- and nano-plastics in aquatic environments: Risks to ecosystems, food web dynamics and human health.
This review synthesized evidence on the toxicological effects of micro- and nanoplastics in aquatic ecosystems, covering risks to individual organisms, disruptions to food web dynamics, and pathways through which plastic exposure poses risks to human health via seafood consumption.
Ecotoxicological effects of microplastics in the marine environment
This review synthesizes ecotoxicological evidence on the impacts of microplastics in the marine environment, drawing on over 50 scientific articles to assess effects at molecular, cellular, organ, individual, and population levels. The authors identify critical methodological limitations including non-standardized particle characteristics, limited species diversity in testing, and scarce community-level studies, concluding that current risk assessment frameworks are insufficient for the more than 5,300 grades of plastics entering marine ecosystems.
Ecotoxicological perspectives of microplastics
This review summarized the ecotoxicological effects of microplastics across aquatic and terrestrial organisms, covering the global scale of plastic production and the chronic harm MPs cause to ecosystems. The paper called for greater research standardization and policy intervention to address the escalating contamination.
Toxicity and biomarkers of micro-plastic in aquatic environment: a review
This review synthesizes literature on the toxicity and biomarker responses of aquatic organisms to microplastics, covering uptake routes, bioavailability factors, and both lethal and sub-lethal effects. It highlights oxidative stress, endocrine disruption, and genotoxicity as consistent toxic mechanisms across diverse aquatic species.
Multiple Effects, Pathways, and Potential Health Risks from Environmental Microplastic Exposure
This review synthesizes nearly two decades of research on the multiple pathways through which environmental microplastics affect human and ecological health, including chemical toxicity, physical impacts, and potential roles as carriers of pathogens and contaminants.