Papers

61,005 results
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Article Tier 2

Zebrafish as a Model Organism to Study Nanomaterial Toxicity

This review examines the use of zebrafish as a model organism for studying nanomaterial toxicity, summarizing how zebrafish embryo and larval assays have been applied to assess the biological effects of metal, carbon, and polymer-based nanomaterials.

2019 Emerging Science Journal 29 citations
Article Tier 2

Toxicological Effects of Nanomaterials on the Aquatic Biota

This review examines the toxicological effects of nanomaterials on aquatic organisms, covering engineered nanomaterials used in industrial applications and their entry into aquatic environments through wastewater and runoff. The review synthesizes evidence on how nanomaterial properties such as size, surface chemistry, and composition determine their bioavailability, uptake, and toxicity across diverse aquatic biota.

2022 Materials research foundations 3 citations
Article Tier 2

Zebrafish Insights into Nanomaterial Toxicity: A Focused Exploration on Metallic, Metal Oxide, Semiconductor, and Mixed-Metal Nanoparticles

This review summarizes research on how various nanomaterials, including nano-sized plastics, affect zebrafish, which are commonly used as stand-ins for studying human health effects. Exposure to nanomaterials caused developmental defects, organ damage, behavioral changes, and reproductive problems in zebrafish. These findings help scientists understand the potential health risks of nanomaterial exposure to humans and the environment.

2024 International Journal of Molecular Sciences 35 citations
Article Tier 2

Multi biomarker approach to assess manganese and manganese nanoparticles toxicity in Pangasianodon hypophthalmus

Researchers exposed catfish (Pangasianodon hypophthalmus) to manganese and manganese nanoparticles at various concentrations, finding that both forms — especially the nanoparticle form — caused significant oxidative stress, immune disruption, neurochemical changes, and liver and gill damage, with effects worsened at higher water temperatures. The study shows that even essential minerals become toxic in their nanoparticle form or at elevated concentrations, particularly in a warming climate.

2023 Scientific Reports 25 citations
Article Tier 2

Toxicological review of micro- and nano-plastics in aquatic environments: Risks to ecosystems, food web dynamics and human health.

This review synthesized evidence on the toxicological effects of micro- and nanoplastics in aquatic ecosystems, covering risks to individual organisms, disruptions to food web dynamics, and pathways through which plastic exposure poses risks to human health via seafood consumption.

2024 Ecotoxicology and environmental safety
Article Tier 2

Nanoplastic toxicity towards freshwater organisms

This systematic review covers nanoplastic toxicity toward freshwater organisms, examining both conventional and bioplastic nanoplastics, and finds that size, shape, and surface chemistry all influence toxicity across a range of invertebrate and vertebrate freshwater species.

2022 Water Emerging Contaminants & Nanoplastics 13 citations
Article Tier 2

Bioaccumulation assessment of nanomaterials using freshwater invertebrate species

Researchers reviewed how freshwater invertebrates such as amphipods and bivalves can be used to test whether engineered nanomaterials accumulate in living organisms, finding that amphipods are the most suitable test species because they can be exposed through both water and food. The study proposes a tiered framework for classifying nanomaterials as bioaccumulative or not, which could reduce the need for vertebrate animal testing.

2021 Environmental Sciences Europe 51 citations
Article Tier 2

Emerging trends in nanoparticle toxicity and the significance of using Daphnia as a model organism

Researchers reviewed why the freshwater crustacean Daphnia is a valuable model organism for nanoparticle toxicity testing, summarizing how nanoparticle size, charge, and surface chemistry influence toxicity in Daphnia and highlighting key knowledge gaps in nanoplastic environmental risk assessment.

2021 Chemosphere 81 citations
Article Tier 2

A holistic approach to assess the toxic behaviour of emerging nanomaterials in aquatic system

Not relevant to microplastics — this book chapter reviews how emerging nanomaterials behave at nano-bio-eco interfaces, discussing toxicity, fate, and exposure potential in aquatic systems without a specific focus on plastic particles.

2023 IWA Publishing eBooks 2 citations
Article Tier 2

Prioritising nano- and microparticles: identification of physicochemical properties relevant for toxicity to Raphidocelis subcapitata and Daphnia magna

Ecotoxicity data for 36 nano- and microparticles of diverse inorganic compositions were generated and used to develop a prioritization framework for identifying which advanced materials pose the greatest human and environmental hazard. The approach provides a practical tool for risk-based regulation of the expanding universe of engineered nano- and microparticles.

2022 Environmental Sciences Europe 16 citations
Article Tier 2

Identifying Knowledge Gaps on Ecotoxicological Assessment of Micro/Nanoplastics with Aquatic Keystone Species

This review identifies knowledge gaps in the ecotoxicological assessment of micro- and nanoplastics across aquatic and terrestrial organisms, highlighting inconsistencies in particle characterization, exposure concentrations, and endpoint selection that limit cross-study comparisons and risk assessment.

2025 Düzce Üniversitesi Bilim ve Teknoloji Dergisi
Article Tier 2

Ecotoxicological effects of emerging pollutants (nanomaterials and microplastics) on fish biology

This review compiles current knowledge on how emerging pollutants including nanomaterials and microplastics affect fish biology, covering impacts on physiology, behavior, and molecular function. Researchers highlight that advanced methods like genomics and micro-CT imaging are revealing new details about how these pollutants damage fish at the cellular and tissue level. The study underscores the growing threat these contaminants pose to aquatic ecosystems and the fish species within them.

2025 Animal Reports 2 citations
Article Tier 2

Aquatic Ecotoxicity of Microplastics and Nanoplastics: Lessons Learned from Engineered Nanomaterials

This review drew lessons from engineered nanoparticle research to improve understanding of aquatic ecotoxicology for microplastics and nanoplastics, identifying shared challenges in dose-response assessment and environmental relevance.

2017 ˜The œhandbook of environmental chemistry 109 citations
Article Tier 2

Trophic transfer of nanomaterials and their effects on high-trophic-level predators

Researchers reviewed 15 years of research on how nanomaterials — including metal-based particles, carbon materials, and nanoplastics — transfer through aquatic and terrestrial food chains, finding that particle-specific transfer factors better capture their movement and that trophic transfer causes measurable toxicity at molecular, physiological, and population levels in predators.

2023 NanoImpact 6 citations
Article Tier 2

Research Progress of Zebrafish Model in Aquatic Ecotoxicology

This review examines how zebrafish are used as model organisms to study the toxic effects of environmental pollutants in water, including microplastics. Zebrafish are ideal because they reproduce quickly, are inexpensive to maintain, and allow researchers to study effects at the genetic, cellular, and whole-organism level. The paper provides a reference guide for scientists choosing model animals for aquatic toxicology research.

2023 Water 48 citations
Article Tier 2

Zebrafish: An emerging model to study microplastic and nanoplastic toxicity

This review highlights zebrafish as an increasingly valuable model organism for studying the toxic effects of micro- and nanoplastics due to their transparent embryos, genetic similarity to humans, and ease of laboratory use. Researchers summarized existing zebrafish studies showing that plastic particles can cross biological barriers and accumulate in tissues, causing various toxic effects. The study positions zebrafish research as a key tool for advancing our understanding of how plastic particle exposure affects living organisms.

2020 The Science of The Total Environment 434 citations
Article Tier 2

Building the Bridge From Aquatic Nanotoxicology to Safety by Design Silver Nanoparticles

This review examined the nanotoxicology of silver nanoparticles in aquatic environments, synthesizing findings on their environmental behavior and biological effects to help bridge the gap between hazard assessment and safety-by-design approaches for engineered nanomaterials.

2022 Frontiers in Bioengineering and Biotechnology 26 citations
Article Tier 2

In vivo biotoxicological assessment of nanoplastics and microplastics predicted using the zebrafish model

This review summarises zebrafish studies on the toxicity of nanoplastics and microplastics, covering developmental, reproductive, neurological, and organ-level effects. It discusses how findings in this widely used model organism may predict human health outcomes and calls for standardised exposure protocols.

2025 PeerJ
Article Tier 2

Ecotoxicity of Petrogenic Plastic Particles in Fish: Implication for Human Health and Environmental Risk Assessment

This review examined the ecotoxicity of petrogenic (petroleum-derived) micro- and nanoplastics on fish, covering how polymer type, size, and associated contaminants influence toxic effects. The authors discuss implications for human health risk assessment given that petrogenic MNPs are among the most prevalent plastic types in aquatic environments.

2025 Food and Drug Safety
Article Tier 2

Effects of polymeric nanoparticles on fish : a multiparametric approach

This study assessed the effects of polymeric nanoparticles on fish using multiple endpoints including growth, reproduction, and gene expression, finding significant biological effects even at low concentrations. The results support the conclusion that plastic nanoparticles pose risks to aquatic vertebrates and provide data relevant to understanding the safety of nanoparticle-containing consumer products.

2017 Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Article Tier 2

A Multilevel Risk Assessment Framework for Nanoplastics in Aquatic Ecosystems

Researchers proposed a multilevel risk assessment framework for nanoplastics in aquatic ecosystems that synthesizes complex ecotoxicological datasets into actionable risk indicators, designed to help policymakers set safety thresholds and make decisions about restrictions on petrochemical-derived materials.

2025 Water 2 citations
Article Tier 2

Zebrafish as Model Organism in Aquatic Ecotoxicology: Current Trends and Future Perspectives

This review assessed zebrafish as model organisms for aquatic ecotoxicology, summarizing current trends and future directions in using Danio rerio to study the effects of environmental pollutants including microplastics. The authors highlight the zebrafish model's utility for integrating molecular, cellular, and whole-organism responses.

2023 IntechOpen eBooks 4 citations
Article Tier 2

Research progress of model animal zebrafish in toxicity evaluation of microplastics

This review examines the use of zebrafish as a model organism for evaluating the toxicity of microplastics, synthesizing research on how microplastic exposure affects development, reproduction, and physiological function in this well-established vertebrate model. The authors highlight zebrafish as a particularly valuable system for mechanistic toxicology studies given its genetic tractability and the breadth of endpoints assessable across life stages.

2022 SHILAP Revista de lepidopterología 1 citations
Article Tier 2

Microplastics in Aquatic Ecosystems: A Review of Ecotoxicological Effects, Exposure Pathways and Trophic Transfer Risks

This review synthesises evidence on the ecotoxicological effects of microplastics in marine, freshwater, and estuarine environments, covering ingestion, bioaccumulation, trophic transfer, and physiological harms across aquatic fauna. It identifies chemical co-contamination and particle size as key modulators of toxicity.

2025 UTTAR PRADESH JOURNAL OF ZOOLOGY