We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Multi biomarker approach to assess manganese and manganese nanoparticles toxicity in Pangasianodon hypophthalmus
Summary
Researchers exposed catfish (Pangasianodon hypophthalmus) to manganese and manganese nanoparticles at various concentrations, finding that both forms — especially the nanoparticle form — caused significant oxidative stress, immune disruption, neurochemical changes, and liver and gill damage, with effects worsened at higher water temperatures. The study shows that even essential minerals become toxic in their nanoparticle form or at elevated concentrations, particularly in a warming climate.
Manganese (Mn) is an essential element for humans and animals including, fish. It is a still poorly studied in aquatic organisms, where it can be noticeably useful for dietary components and also found pollutant in aquatic environment at high concentrations. On the above information, an experiment was delineated to determine the lethal concentration of manganese (Mn) and manganese nanoparticles (Mn-NPs) alone and with high temperature (34 °C) and its effect on various biochemical markers in Pangasianodon hypophthalmus. The median lethal concentration (96-LC50) of Mn alone (111.75 mg L-1) and along with high temperature (110.76 mg L-1), Mn-NPs alone (93.81 mg L-1) and with high temperature (34 °C) (92.39 mg L-1) was determined in P. hypophthalmus. The length and weight of the fish were 6.32 ± 0.23 cm and 7.57 ± 1.35 g. The present investigation used five hundred forty-six fish, including range finding (216 fish) and definitive test (330 fish). The acute definitive doses were applied to assess the effect of oxidative stress, glycolytic biomarkers, protein biomarkers, fish immunity, neurotransmitter, energy level, stress hormone and histopathology. Oxidative stress (catalase, superoxide dismutase, glutathione-s-transferase and glutathione peroxidase), stress biomarkers (lipid peroxidation, cortisol, heat shock protein, and blood glucose), lactate and malate dehydrogenase, alanine and aspartate aminotransferase, a neurotransmitter, glucose-6-phosphate dehydrogenase (G6PDH), ATPase, immune system biomarkers (NBT, total protein, albumin, globulin and A:G ratio) were altered with exposure to Mn and Mn-NPs. The histopathology of the liver and gill were also changed due to exposure to Mn and Mn-NPs. The bioaccumulation of Mn in the liver, gill, kidney, brain and muscle tissues, and experimental water at different intervals of 24, 48, 72 and 96 h were determined. Based on the present results, it is strongly suggested that Mn and Mn-NPs exposure alone and with high temperature (34 °C) enhanced toxicity and altered biochemical and morphological attributes. This study also suggested that essential elements in both forms (inorganic and nano) at higher concentrations of Mn and Mn-NPs lead to pronounced deleterious alteration in cellular and metabolic activities and histopathology of P. hypophthalmus.
Sign in to start a discussion.
More Papers Like This
Catfish as an Ecotoxicological Model for Assessment of Nanoparticle Toxicity Profiling
This review examines catfish as an ecotoxicological model organism for assessing nanoparticle toxicity, evaluating approaches to using catfish as bioindicators in aquatic ecosystems where nanomaterial contamination poses poorly understood environmental risks.
Will temperature rise change the biochemical alterations induced in Mytilus galloprovincialis by cerium oxide nanoparticles and mercury?
Researchers exposed mussels (Mytilus galloprovincialis) to cerium oxide nanoparticles and mercury alone and in combination at current and elevated temperatures, finding that mercury caused the most significant metabolic damage, CeO2 nanoparticles partially counteracted mercury's effects, and elevated temperature overrode both — highlighting that climate warming may amplify toxicological impacts in coastal marine organisms.
Effects of polymeric nanoparticles on fish : a multiparametric approach
This study assessed the effects of polymeric nanoparticles on fish using multiple endpoints including growth, reproduction, and gene expression, finding significant biological effects even at low concentrations. The results support the conclusion that plastic nanoparticles pose risks to aquatic vertebrates and provide data relevant to understanding the safety of nanoparticle-containing consumer products.
Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism
This review examines how microplastics, pesticides, and nanoparticles harm fish by causing oxidative stress, DNA damage, immune system disruption, and changes in gut bacteria. Since contaminated fish is a major pathway for microplastics and pesticides to enter the human diet, declining fish health and quality directly affect food safety and human nutrition worldwide.
Evaluation of distribution, chemical speciation, and toxic effects of CuO and ZnO nanoparticles in Daphnia magna and Danio rerio
Copper oxide and zinc oxide nanoparticles were toxic to both water fleas (Daphnia magna) and zebrafish at low concentrations, accumulating in tissues and causing oxidative damage. These nanoparticles are used in plastics as stabilizers and antimicrobials, making their aquatic toxicity relevant to assessing risks from plastic-derived nanoparticle release.