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61,005 resultsShowing papers similar to A Comparative Systematic Analysis of The Influence of Microplastics on Colon Cells, Mouse and Colon Organoids
ClearImpact of Micro‐ and Nano‐Plastics on Human Intestinal Organoid‐Derived Epithelium
Researchers developed a detailed protocol for testing how micro and nanoplastics affect the human intestinal lining using patient-derived intestinal organoids, which are lab-grown miniature gut tissues that closely mimic real human intestines. The model includes specialized M cells that are key to how particles cross the gut barrier, making it more realistic than standard cell line experiments. This advanced testing approach will help scientists better understand how microplastics we swallow through food and water interact with and potentially damage the human digestive system.
Utilization of intestinal organoid models for assessment of micro/nano plastic-induced toxicity
This review examines the use of intestinal organoid models as a more physiologically accurate alternative to traditional cell cultures and animal experiments for studying micro- and nanoplastic toxicity. Researchers highlight that organoids can mimic the complex structure of intestinal tissue, providing better insight into how plastic particles affect the gut. The study suggests that while organoid-based research is still in its early stages, it holds significant promise for advancing our understanding of plastic-related health effects.
Organoid-based platforms for investigating microplastic-induced human organ toxicity
This review examines how lab-grown miniature organ models, called organoids, are being used to study the health effects of micro- and nanoplastic exposure on human tissues. Evidence from brain, heart, lung, liver, kidney, and intestinal organoid models shows that plastic particles can cause oxidative stress, inflammation, cell death, and impaired tissue development. The technology offers a more realistic way to study plastic toxicity compared to traditional cell culture or animal experiments.
Predictive metabolomic signatures for safety assessment of three plastic nanoparticles using intestinal organoids
Scientists used lab-grown miniature intestines (organoids) from mice to study how three types of nanoplastics affect gut cells. All three plastic types reduced energy production in cells, caused oxidative stress, and disrupted important cell-signaling pathways. The study found that metabolic profiling could detect subtle damage from nanoplastics even before obvious cell harm appeared, offering a sensitive new way to assess the gut health risks of plastic particle exposure.
Advancing Microplastic and Nanoplastic Toxicity Assessment: Insights from Human Organoid Models
This review examines how human stem cell-derived organoids are being used to study the toxic effects of microplastics and nanoplastics on human tissues. Researchers found that organoid models of the gut, lung, brain, and other organs provide more human-relevant data than traditional animal testing for assessing plastic particle toxicity. The study suggests that organoid technology could significantly advance understanding of how microplastics affect human health at the tissue and organ level.
Biological effects of polystyrene micro- and nano-plastics on human intestinal organoid-derived epithelial tissue models without and with M cells.
Researchers exposed human intestinal organoid-derived epithelial tissue models with and without M cells to polystyrene micro- and nano-plastics, finding that nano-plastics caused greater disruption of barrier integrity and uptake than micro-plastics, and that M cell-containing models showed enhanced particle translocation compared to standard epithelial models.
Application of organoid technology in the human health risk assessment of microplastics: A review of progresses and challenges
This review examines how organoid technology -- miniature lab-grown versions of human organs made from stem cells -- can be used to study the health effects of microplastics more accurately than traditional animal testing. Organoids of the gut, lung, brain, liver, and other organs can better predict how microplastics affect human tissues, potentially accelerating our understanding of the real health risks these particles pose.
Effect of Microplastic Intake on Intestinal and Pancreatic Cell Damage
Researchers investigated the effects of oral microplastic administration on the intestinal and pancreatic cells of Rattus norvegicus Wistar rats to assess organ-level damage from ingestion via contaminated food and drink. Using a quantitative experimental design, they found that oral microplastic intake impairs the function of the small intestine, large intestine, and pancreas, providing experimental evidence for cellular damage in key digestive and endocrine organs following microplastic ingestion.
Effect of microplastics and nanoplastics in gastrointestinal tract on gut health: A systematic review.
This systematic review of 30 in vitro studies found that microplastics and nanoplastics cause size- and concentration-dependent damage to human gastrointestinal cells, including increased oxidative stress, mitochondrial dysfunction, inflammation, and apoptosis. Smaller particles consistently showed greater cellular uptake and biological effects, though chronic low-dose exposure generally produced minimal impacts.
Microplastic effects on mouse colon in normal and colitis conditions: A literature review
This literature review examined studies on how microplastic exposure affects the mouse colon under both normal and inflammatory conditions. Evidence indicates that microplastics may contribute to intestinal inflammation and could worsen existing colitis. The review highlights the need for further research to better understand how microplastic ingestion may influence gut health in humans.
Influence of Microplastics on Morphological Manifestations of Experimental Acute Colitis
Researchers fed polystyrene microplastics to mice for six weeks and found that healthy mice developed changes in their colon lining, including altered mucus composition and immune cell populations. When mice with experimentally induced colitis also consumed microplastics, their intestinal inflammation was significantly more severe. The study suggests that microplastic exposure may worsen inflammatory bowel conditions.
Colon Organoids as Experimental Models to Study the Effect of Micro-Nanoparticles as a Driver of Early-Onset Colon Cancer
Researchers used human colon organoids—three-dimensional tissue models derived from patient biopsies—as experimental platforms to investigate whether micro- and nanoplastic exposure could drive early-onset colorectal cancer development. Organoid exposure to various micro/nanoplastic types induced cellular stress responses, barrier disruption, and pro-carcinogenic gene expression patterns relevant to colorectal cancer initiation.
The potential effects of microplastic pollution on human digestive tract cells
Researchers tested polystyrene particles of four different sizes on human colon and small intestine cells to assess the potential effects of microplastic ingestion. They found that the smallest nanoscale particles were more readily taken up by cells and caused greater reductions in cell viability and increased oxidative stress. The study suggests that smaller plastic particles may pose a greater risk to the human digestive tract than larger ones.
Human organoids to assess environmental contaminants toxicity and mode of action: towards New Approach Methodologies
This review explores how human organoids, miniature lab-grown organ models, can be used to test the toxicity of environmental contaminants including microplastics. These 3D tissue models offer a more accurate picture of how pollutants affect human cells than traditional lab tests, though more work is needed to simulate the chronic, low-dose exposures people actually experience.
Detection of microplastics in human colectomy specimens
Researchers examined tissue samples from patients who had colon surgery and detected microplastics in the specimens. The findings suggest that microplastics are commonly present in the human colon, adding to a growing body of evidence that these particles accumulate in the human digestive system.
Microplastics and health hazards: gastrointestinal risk assessment across a multi-species perspective
This review assesses the gastrointestinal health risks of micro- and nanoplastics across multiple species, from aquatic organisms to mammals, examining how these particles interact with the digestive system. Researchers found that microplastics can cause gut inflammation, alter the microbiome, and potentially cross the intestinal barrier into other tissues. The study highlights that understanding effects across species can help predict potential risks to human digestive health.
Microplastics in our diet: complementary in vitro gut and epithelium models to understand their fate in the human digestive tract.
Researchers used complementary in vitro gut models to study how microplastics behave during human digestion, finding that digestive conditions alter microplastic surface properties and their interactions with gut cells. The work advances understanding of how ingested microplastics may affect the human digestive system.
Influence of Microplastics on Manifestations of Experimental Chronic Colitis
Researchers studied whether consuming microplastics worsens chronic colon inflammation in mice. While microplastics alone did not cause visible damage to healthy intestines, they significantly increased the severity of colitis symptoms, including more ulcers and greater inflammatory cell infiltration, in mice with pre-existing colon inflammation. The findings suggest that microplastic exposure may be particularly concerning for individuals who already have inflammatory bowel conditions.
Distinct accumulation of nanoplastics in human intestinal organoids
Researchers exposed human intestinal organoids to polystyrene nanoplastics and found that these tiny particles accumulated in distinct patterns within the gut tissue model. The study observed that nanoplastic uptake increased with concentration and caused measurable changes in the intestinal cells. These findings provide early evidence that nanoplastics can be absorbed by human intestinal tissue, raising questions about potential long-term health effects from dietary exposure.
Microplastics and Colorectal Cancer: Presence in Human Colorectal Tissues and Associations with Tumor Biology- A Systematic Review
This review of 13 studies found that tiny plastic particles called microplastics are present in human colon tissues, with higher amounts found in cancerous tumors compared to healthy tissue. The research suggests these plastic particles may contribute to colon cancer development by causing inflammation and creating conditions that help tumors grow. While more research is needed to prove a direct cause-and-effect relationship, this highlights growing concerns about how plastic pollution in our environment and food supply might affect human health.
Effect of microplastics and nanoplastics in gastrointestinal tract on gut health: A systematic review.
This systematic review provides the first comprehensive look at how microplastics and nanoplastics affect the human gut using laboratory models. The findings help explain how these tiny particles may damage the digestive tract lining and trigger inflammation, which is important for understanding the health risks of swallowing microplastics in food and water.
Impact of micro- and nanoplastics on gastrointestinal diseases: Recent advances
This review summarizes how micro- and nanoplastics can harm the digestive system by causing oxidative stress, inflammation, cell death, and disruption of gut bacteria. These connected pathways can damage the intestinal lining and may contribute to conditions like inflammatory bowel disease and colorectal cancer. The findings highlight the importance of understanding how everyday plastic exposure through food and water could affect gut health over time.
A digestive system microphysiological platform for assessment of internal-exposure risks and metabolic disease mechanisms induced by multi-size nano-plastics.
Researchers developed a digestive system organ-on-a-chip microphysiological platform to assess how nanoplastics (NPs) are absorbed, metabolized, and cause internal exposure risks. The system revealed size-dependent toxic effects of NPs on liver cells and lipid metabolism, providing mechanistic insights into NP-associated liver disease risk.
Recent progress of microplastic toxicity on human exposure base on in vitro and in vivo studies
This review summarizes recent research on how microplastics affect the human body based on lab cell studies and animal experiments. Evidence shows microplastics can damage multiple organ systems including the digestive, respiratory, nervous, reproductive, and cardiovascular systems. The paper identifies significant gaps in our understanding and calls for more research using realistic exposure levels to better assess the true risk to human health.