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Papers
61,005 resultsShowing papers similar to Identification and validation of novel signature associated with hepatocellular carcinoma prognosis using Single-cell and WGCNA analysis
ClearCorrelation Between Tumor Differentiation and Biomarkers in Hepatocellular Carcinoma: Implications for Early Diagnosis and Treatment
Researchers examined the correlation between tumor differentiation levels and biomarker expression in patients with hepatocellular carcinoma. The study found significant associations between tumor grade and certain biomarker levels, suggesting these markers may have potential value for early diagnosis and treatment planning in liver cancer.
Endoplasmic Reticulum Stress-Related Signature for Predicting Prognosis and Immune Features in Hepatocellular Carcinoma
Researchers developed a four-gene endoplasmic reticulum stress-based prognostic model for hepatocellular carcinoma using bioinformatics approaches, finding that higher risk scores correlated with advanced tumor stage, HBV infection, and worse survival outcomes. The model also predicted differences in immune cell infiltration profiles, suggesting potential utility for guiding immunotherapy decisions.
Endoplasmic Reticulum Stress-related Classification for Prognosis Prediction in Hepatocellular Carcinoma
Researchers used gene expression data to create an endoplasmic reticulum stress-based classification system for predicting outcomes in liver cancer patients. The model identified patient subgroups with significantly different survival rates.
Exposure to microplastics and liver oncogenesis: A comprehensive review on molecular mechanisms and pathogenic pathways
Researchers reviewed mechanisms by which microplastic exposure may promote liver cancer, identifying oxidative stress, mitochondrial dysfunction, inflammatory signaling, and epigenetic disruption as key pathways, while noting that microplastics can also carry heavy metals and organic pollutants that synergistically amplify hepatotoxic and carcinogenic risk.
Identification of functional immune and neuronal tumour cells in glioma
Researchers developed the Single Cell Rule Association Mining (SCRAM) computational tool to integrate RNA-inferred genomic alterations with co-occurring cell type signatures at single-cell resolution, applying it to glioma to identify functional immune and neuronal tumour cells and distinguish tumour from non-tumour cells with greater precision than existing annotation algorithms.
Early Predictor Tool of Disease Using Label-Free Liquid Biopsy-Based Platforms for Patient-Centric Healthcare
Algorithmic analysis of patient-derived cell clusters from liquid biopsy samples was combined with tumor models to develop an early disease prediction tool applicable across cancer types. The approach offers a label-free, non-invasive method for early cancer detection that could supplement or reduce reliance on conventional tissue biopsy.
Characterization of Microplastics in Human Gastric Cancer and Control Tissues and Analysis of Associated Genetic Features
Researchers detected and characterized microplastics in human gastric cancer tissue and adjacent healthy tissue, finding significantly higher microplastic concentrations in cancer tissue, and used transcriptome sequencing to explore potential molecular mechanisms linking microplastic exposure to gastric cancer development.
Single-cell transcriptomic dissection of the cellular and molecular events underlying the triclosan-induced liver fibrosis in mice
Researchers used single-cell analysis to map exactly which liver cell types are damaged by triclosan — a common antimicrobial found in personal care products — and found it activates star-shaped cells called hepatic stellate cells, leading to liver scarring (fibrosis). This is the first detailed cellular atlas of triclosan's toxic effects on the liver.
Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice
Researchers used multi-omics analysis to reveal that liver injury in colitis mice is linked to intestinal dysbiosis and altered host-microbiota interactions, with gut bacterial shifts correlating to immune and metabolic changes in the liver.
Environmental PET-microplastic exposure and risk of non-alcoholic fatty liver disease: An integrated computational toxicology and multi-omics study
Researchers used computational toxicology and machine learning to identify six key genes linking PET microplastic exposure to non-alcoholic fatty liver disease (NAFLD), with the model achieving high diagnostic accuracy and molecular docking suggesting that PET-derived chemicals may directly bind to proteins controlling liver fat metabolism.
Mitochondrial Quality Control and Metabolic Reprogramming in Hepatocellular Carcinoma: Implications for Immunotherapy and Treatment Resistance
Scientists reviewed research showing that liver cancer cells damage the tiny energy factories (mitochondria) inside immune cells, making it harder for the body's natural defenses to fight the cancer. When immune cells can't get enough energy, they become "exhausted" and stop working properly against tumors. The researchers suggest that targeting these energy problems in cells could help improve cancer treatments and make immunotherapy work better for liver cancer patients.
Single-cell transcriptome analysis of liver immune microenvironment changes induced by microplastics in mice with non-alcoholic fatty liver
Using advanced single-cell analysis, researchers showed that microplastics worsened non-alcoholic fatty liver disease in mice fed a high-fat diet by changing how immune cells behaved in the liver. Microplastic exposure amplified inflammatory responses and altered the communication between different liver cell types. This study is important because it reveals specific immune mechanisms by which microplastics could worsen liver disease, a condition already affecting roughly one in four adults worldwide.
The Expectation and Reality of the HepG2 Core Metabolic Profile
This meta-analysis of 56 metabolomic datasets identified 288 core metabolites in HepG2 liver cells, revealing significant gaps and inconsistencies in how metabolomic studies report and standardize their findings. While focused on cell biology methodology rather than microplastics, HepG2 cells are commonly used in toxicology studies to assess the effects of microplastic exposure on liver function.
Molecular regulatory networks of microplastics and cadmium mediated hepatotoxicity from NAFLD to tumorigenesis via integrated approaches
This study mapped out how microplastics and the toxic metal cadmium work together to damage the liver, tracing a progression from fatty liver disease to cirrhosis and eventually liver cancer. Cadmium activates genes linked to cell growth and tumor formation, while microplastics trigger cell death pathways related to inflammation. When combined, the two pollutants accelerate liver damage more than either one alone, raising concerns about real-world exposure where people encounter both simultaneously.
Integrated transcriptomic and metabolomic analyses to decipher the regulatory mechanisms of polystyrene nanoplastic-induced metabolic disorders in hepatocytes
Using combined transcriptomic and metabolomic analysis, this study found that polystyrene nanoplastics disrupt lipid and amino acid metabolism in hepatocytes, identifying key regulatory genes and providing data relevant to assessing health risks from nanoplastic exposure.
A computational framework for multi-scale data fusion in assessing the associations between micro- and nanoplastics and human hepatotoxicity
Researchers developed a computational toxicology framework integrating multi-source data and network analysis to map associations between micro- and nanoplastics and hepatotoxicity, identifying key molecular pathways through which MNPs may damage the liver, offering a scalable alternative to traditional in vivo testing.
Single-cell transcriptomic analysis of mouse liver reveals nonparenchymal cells’ intricate responses to PCB126 exposure
Using single-cell RNA sequencing, researchers found that PCB126 exposure triggers cell-type-specific responses in mouse liver, activating the AhR signaling pathway mainly in endothelial cells while altering immune cell transcriptional profiles, revealing previously hidden heterogeneity in PCB toxicity.
Microplastics and nanoplastics: Emerging drivers of hepatic pathogenesis and metabolic dysfunction
This review examines emerging evidence linking micro- and nanoplastic exposure to liver disease, including metabolic dysfunction-associated liver disease, cirrhosis, and liver cancer. Researchers found that these particles may contribute to liver damage through oxidative stress, inflammation, and disruption of metabolic pathways. The study highlights the need for further research into how environmental plastic contamination may be influencing the rising rates of liver disease worldwide.
Mechanism of Pyroptosis in Acute Liver Injury and Prospect of Targeted Therapy
This review examined the role of pyroptosis—an inflammatory form of programmed cell death—in acute liver injury, covering the gasdermin-mediated molecular mechanisms involved. The authors proposed that targeting pyroptosis pathways may offer new therapeutic strategies for conditions such as drug-induced liver injury and ischemia-reperfusion damage.
Comprehensive Transcriptome Profiling of Antioxidant Activities by Glutathione in Human HepG2 Cells
Researchers used DNA microarray analysis to map the full range of genes activated by the antioxidant glutathione in human liver cells under both normal and stressed conditions. They found that glutathione activates protective antioxidant pathways, including the NRF2 system, and regulates a broad set of biological processes beyond its known role. The study provides a comprehensive molecular picture of how glutathione supports liver cell defense against oxidative damage.
Meta-analysis of H. pylori and the gut microbiome interactions and clinical outcomes
This meta-analysis identified specific gut microbial signatures associated with H. pylori infection and disease progression, offering predictive models for early diagnosis and risk stratification. The findings support microbiome-based approaches to personalized treatment of H. pylori-associated gastrointestinal disorders.
Serum Glutamic Oxalacetic Transaminase Activity as an Index of Liver Cell Injury: a Preliminary Report
Researchers investigated serum glutamic oxalacetic transaminase (SGOT) activity as a biomarker for liver cell injury, presenting preliminary evidence that elevated enzyme levels in serum correlate with hepatocellular damage and could serve as a diagnostic index.
Single-cell transcriptomic analysis reveals heterogeneity of the patterns of responsive genes and cell communications in liver cell populations of zebrafish exposed to polystyrene nanoplastics
Researchers used single-cell gene analysis to examine how polystyrene nanoplastics affect different cell types in zebrafish livers. They discovered that various liver cell populations responded to nanoplastic exposure in distinctly different ways, with some cell types showing more disruption to fat metabolism and stress response genes than others. The study reveals that nanoplastic toxicity in the liver is not uniform and that certain cell populations may be more vulnerable than previously understood.
The double-edged role of hydrogen sulfide in the pathomechanism of multiple liver diseases
This review examined the double-edged role of hydrogen sulfide (H2S) as a gaseous signaling molecule across multiple liver disease conditions, summarizing its protective antioxidant and anti-inflammatory effects alongside its potential to exacerbate damage at higher concentrations. The findings suggest context-dependent therapeutic windows for H2S modulation in liver disease.