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Article
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Tier 2
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Original research — experimental, observational, or case-control study. Direct primary evidence.
Human Health Effects
Nanoplastics
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Integrated transcriptomic and metabolomic analyses to decipher the regulatory mechanisms of polystyrene nanoplastic-induced metabolic disorders in hepatocytes
Environmental Science Nano
2025
Yuting Fang,
Yukang Zhang,
Tingting Wei,
Huraira Akhtar,
Yuqing Song,
Yuqing Song,
Yajie Wang,
Man Yang,
Rongzhang Hao,
Yanbo Li,
Zhiwei Sun,
Ji Wang
Summary
Using combined transcriptomic and metabolomic analysis, this study found that polystyrene nanoplastics disrupt lipid and amino acid metabolism in hepatocytes, identifying key regulatory genes and providing data relevant to assessing health risks from nanoplastic exposure.
This study reveals that PSNPs disrupt hepatocyte lipid and amino acid metabolism and identifies key genes using an integrated omics approach. It provides data for understanding MNP hazards and assessing health risks.