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61,005 resultsShowing papers similar to Research progress on the cellular toxicity caused by microplastics and nanoplastics
ClearMicro- and nanoplastic induced cellular toxicity in mammals: A review
This review examines research on how micro- and nanoplastics cause cellular damage in mammalian systems, covering both laboratory and animal studies. Evidence indicates that these particles can trigger oxidative stress, inflammation, and DNA damage in cells, with smaller nanoplastics generally showing greater toxicity due to their ability to penetrate cell membranes more readily.
Microplastics and Nanoplastics in Health Concerning Cellular Toxicity Mechanisms, Exposure Pathways, and Global Mitigation Strategies
This review synthesizes current knowledge on how micro- and nanoplastics cause cellular damage in the human body, covering mechanisms like oxidative stress, inflammation, DNA damage, and disruption of cell signaling pathways. Researchers note that exposure occurs through multiple routes including ingestion and inhalation, allowing particles to reach organs throughout the body. The study highlights significant gaps in understanding long-term and low-dose exposure effects that are most relevant to everyday human contact with these particles.
Exploring toxicological pathways of microplastics and nanoplastics: Insights from animal and cellular models
This review examines what animal and cell studies have revealed about how microplastics and nanoplastics cause harm at the molecular level, including promoting inflammation, oxidative stress, and cell death. Most research has focused on reproductive toxicity and polystyrene particles, while effects on the gut, brain, and heart remain understudied. The authors note that many experiments use unrealistic concentrations and synthetic particles, making it difficult to apply the results to real-world human exposure.
Cellular Impact of Micro(nano)plastics on Human Health: A Review.
This review examined how micro(nano)plastics (MNPs) entering the human body through ingestion, inhalation, and skin contact affect cells and tissues. It synthesized evidence of oxidative stress, inflammation, DNA damage, and endocrine disruption associated with MNP exposure.
Recent insights into uptake, toxicity, and molecular targets of microplastics and nanoplastics relevant to human health impacts
This review summarizes what scientists know about how tiny plastic particles enter the human body and cause harm at the cellular level, including through inflammation, oxidative stress, and disruption of important cell signaling pathways. Americans are estimated to consume tens of thousands to millions of micro- and nanoplastic particles per year, and these particles can penetrate cells and tissues throughout the body.
Key mechanisms of micro- and nanoplastic (MNP) toxicity across taxonomic groups
This review examines the key ways micro- and nanoplastics cause biological harm across different types of organisms, from bacteria to humans. Researchers identified several common toxicity mechanisms including cell membrane damage, reactive oxygen species generation, DNA damage, and disruption of cellular structures like lysosomes and mitochondria. The study found that toxicity depends heavily on particle size, surface characteristics, and polymer type, and that human cell studies provide especially valuable insights into potential health risks.
Cellular and Systemic Impacts of Microplastics and Nanoplastics
This review synthesized evidence on how micro- and nanoplastics cause cellular and systemic harm through inflammation, oxidative stress, mitochondrial dysfunction, and endocrine disruption across multiple organ systems. The authors emphasize that exposure is ubiquitous and that health impacts are no longer speculative.
Mechanisms of Cell Toxicity Caused by Degraded Microplastics
This review examined the molecular and cellular mechanisms by which degraded microplastics cause toxicity, focusing on how physical and chemical changes during environmental weathering alter plastic particle biological activity. The paper discussed oxidative stress, membrane disruption, and inflammatory pathways as key toxicity mechanisms of degraded microplastic fragments.
Recent consequences of micro-nanaoplastics (MNPLs) in subcellular/molecular environmental pollution toxicity on human and animals
This review examines the subcellular and molecular mechanisms by which micro- and nanoplastics cause toxicity in humans and animals, focusing on oxidative stress, inflammation, cell death pathways, and endocrine disruption at the cellular level.
Molecular toxicity of nanoplastics involving in oxidative stress and desoxyribonucleic acid damage
This review examines the molecular mechanisms by which nanoplastics induce oxidative stress and DNA damage in biological systems, synthesizing findings from cell culture and animal studies. The evidence suggests that nanoplastics can cause genotoxic effects at the cellular level, which is relevant to understanding potential long-term health risks of chronic nanoplastic exposure.
Micro/nanoplastics and human health: A review of the evidence, consequences, and toxicity assessment
This review summarizes evidence that micro and nanoplastics have been found in multiple human organs and body fluids, where they can alter cell shape, damage mitochondria, reduce cell survival, and cause oxidative stress. The health effects depend heavily on the size, shape, and chemical makeup of the particles, with smaller nanoplastics generally posing the greatest risk because they penetrate deeper into tissues. The review provides a framework for assessing how dangerous different types of plastic particles are to human health.
Bioeffects of Nanoplastics: DNA Damage and Mechanism
This review examines how nanoplastics, plastic particles smaller than one micrometer, can damage DNA in cells. The authors explain that nanoplastics may cause genetic damage through oxidative stress, inflammation, and direct interference with cellular processes, which raises concerns about potential long-term health effects including cancer risk.
Toxicity in vitro reveals potential impacts of microplastics and nanoplastics on human health: A review
This review summarizes laboratory cell-culture studies examining the potential health impacts of microplastics and nanoplastics on human cells. Researchers found evidence that these particles can cause oxidative stress, inflammation, and disruption to normal cell functions across multiple cell types. The study suggests that while more research is needed, the in vitro evidence indicates microplastics and nanoplastics have the potential to affect human health through several biological pathways.
Cellular and Molecular Mechanisms of Micro- and Nanoplastics Driving Adverse Human Health Effects
This review examines the biological mechanisms by which micro- and nanoplastics may cause harm in humans, including oxidative stress, inflammation, disruption of protective barriers, and immune system problems. Evidence from lab and animal studies suggests these particles can affect the gut, heart, brain, and reproductive systems, though human data is still limited to detecting plastics in tissues rather than proving they cause specific diseases. The authors highlight that most studies use higher doses than people actually encounter, making it important to develop research models that better reflect real-world chronic exposure.
Plastic pollution and its pathophysiological impacts on mammalian cells
This review examines the pathophysiological impacts of microplastics and nanoplastics on mammalian cells, discussing how environmental degradation of larger plastics generates micro- and nano-scale fragments that enter organisms through ingestion, accumulate via trophic transfer, and cause cellular toxicity. The authors synthesize laboratory evidence on MP and NP interactions with mammalian cells including membrane disruption, inflammation, and genotoxicity.
Cellular and Systemic Effects of Micro- and Nanoplastics in Mammals—What We Know So Far
This review summarized known cellular and systemic effects of micro- and nanoplastics in mammals, finding that while ingestion is common, knowledge of health impacts remains limited, with oxidative stress and inflammation as the most reported biological responses.
Potential lifetime effects caused by cellular uptake of nanoplastics: A review
Researchers reviewed the potential lifetime health effects of nanoplastic uptake at the cellular level, noting that unlike larger micro- and macroplastics, nanoplastics can be absorbed directly by human cells. The study suggests that cellular uptake of nanoplastics may lead to various adverse effects including cytotoxicity, inflammation, and oxidative stress, though research on nanoplastic interactions with human cells is still in its early stages.
Microplastics and human health: unraveling the toxicological pathways and implications for public health
This review pulls together recent research on how microplastics enter the human body and cause cellular damage through inflammation, oxidative stress, and direct cell injury. The authors highlight that microplastics can also amplify the harmful effects of other environmental pollutants they carry, creating combined health risks that are greater than either threat alone.
A review on microplastics and nanoplastics in the environment: Their occurrence, exposure routes, toxic studies, and potential effects on human health
This review summarizes what is known about how microplastics and nanoplastics enter the human body through food, air, and skin contact, and what they do once inside. Studies on cells and animals show these tiny particles can cause oxidative stress, DNA damage, inflammation, and harm to the immune, digestive, reproductive, and nervous systems. The research makes clear that microplastics are not just an environmental problem but a direct concern for human health.
Important Factors Affecting Induction of Cell Death, Oxidative Stress and DNA Damage by Nano- and Microplastic Particles In Vitro
This review examines what makes tiny plastic particles more or less toxic to cells, finding that smaller particles, longer exposure times, higher concentrations, and positive electrical charges all increase harm. Importantly, the study shows that nanoplastics can penetrate cells, generate damaging molecules called reactive oxygen species, and cause DNA damage, with normal cells being more vulnerable than cancer cells.
Impact of microplastics and nanoplastics on human Health: Emerging evidence and future directions
This review summarizes current evidence on how micro- and nanoplastics enter the human body through food, air, and skin contact, and the cellular damage they may cause. While microplastic pollution is a recognized environmental hazard, the authors note that definitive evidence linking plastic particle exposure to specific health outcomes in humans is still limited and more realistic exposure studies are needed.
Molecular and Cellular Effects of Microplastics and Nanoplastics in the Pathogenesis of Cardiovascular, Nervous, Urinary, Digestive, and Reproductive System Diseases: A Global Systematic Review
This systematic review examines how micro- and nanoplastics cause damage at the cellular level across multiple body systems, including the heart, brain, kidneys, gut, and reproductive organs. The key mechanisms include oxidative stress, inflammation, and disruption of protective barriers in the body, suggesting that ongoing plastic exposure may contribute to a wide range of health problems.
Mechanistic insight into potential toxic effects of microplastics and nanoplastics on human health
This review summarizes how microplastics and nanoplastics enter the body through breathing, eating, and skin contact, then travel through the bloodstream to deposit in organs. Studies show they can cause oxidative stress, inflammation, immune dysfunction, genetic damage, developmental abnormalities, and potentially cancer, though most evidence comes from cell and animal studies rather than human research.
Atmospheric microplastic and nanoplastic: The toxicological paradigm on the cellular system
This review examines how airborne microplastics and nanoplastics affect human cells after being inhaled into the lungs. Because these particles are tiny and lightweight, they can penetrate deep into lung tissue and potentially enter the bloodstream. Studies on human cell lines show that inhaled plastic particles can cause inflammation, oxidative stress, and DNA damage, raising concerns about long-term respiratory and systemic health effects.