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Papers
61,005 resultsShowing papers similar to A single-cell atlas of the single versus multiple parous Hu Sheep ovary
ClearSingle-cell sequencing reveals the reproductive variations between primiparous and multiparous Hu ewes
This paper is not about microplastics; it uses single-cell sequencing of ovarian tissue to investigate genetic mechanisms driving litter size differences between high- and low-reproductive Hu sheep ewes.
Single-cell sequencing reveals the reproductive variations between primiparous and multiparous Hu ewes
Researchers used single-cell sequencing to compare reproductive differences between first-time and experienced mother Hu ewes. The study identified key differences in gene expression within granulosa cells, suggesting these cells play a critical role in determining reproductive capacity. Several specific genes were highlighted as important regulators of follicular development and overall fecundity in sheep.
Transcriptome Profiling of Developing Testes and Spermatogenesis in the Qianbei Ma Goat
This paper is not relevant to microplastics research — it uses RNA sequencing to profile gene expression changes during testis development and spermatogenesis in Qianbei Ma goats at different stages of maturity.
Insect Insights at the Single-Cell Level: Technologies and Applications
This paper is not about microplastics; it reviews single-cell RNA sequencing technologies and their applications in insect biology research.
Polystyrene nanoplastics disrupt ovarian development via cytoskeletal remodeling and epigenetic reprogramming particularly in granulosa cells
Researchers used single-cell RNA sequencing to map polystyrene nanoplastic toxicity in mouse ovaries, identifying granulosa cells as the primary target and showing that 100 nm particles trigger F-actin cytoskeletal remodeling, STAT1-driven epigenetic reprogramming, and necroptosis, disrupting follicle development and hormone production.
Microplastics are present in women’s and cows’ follicular fluid and polystyrene microplastics compromise bovine oocyte function in vitro
Researchers detected microplastics in both women's and cows' follicular fluid for the first time, and showed that polystyrene microplastics impair bovine oocyte function in vitro, raising concern that environmental microplastic exposure may be contributing to declining reproductive health.
DRscDB: A single-cell RNA-seq resource for data mining and data comparison across species
This paper describes a new database for analyzing single-cell gene expression data across different animal species including fruit flies. This genomics database tool is unrelated to microplastic research.
Effective multi-modal clustering method via skip aggregation network for parallel scRNA-seq and scATAC-seq data
This paper presents a new computational method for analyzing single-cell genomic data by clustering cells based on both their gene expression and chromatin accessibility patterns. The technique uses a skip aggregation network to better integrate information from multiple data types. While not related to microplastics, this type of advanced analytical tool could potentially be applied to study how microplastic exposure affects gene expression at the single-cell level in human tissues.
Additional file 1 of Single-cell RNA-seq analysis decodes the kidney microenvironment induced by polystyrene microplastics in mice receiving a high-fat diet
Researchers used single-cell RNA sequencing to decode kidney microenvironmental changes induced by polystyrene microplastics in mice fed a high-fat diet, characterizing mural cell and mesangial cell heterogeneity, DEG profiles, and pathway enrichment in affected renal tissue.
Effects of Microplastics on the Central Reproductive Neuroendocrine System in a Sheep Model
Scientists gave sheep tiny plastic particles (microplastics) and found they disrupted the brain signals that control reproduction by lowering key hormones needed for fertility. Since humans are constantly exposed to microplastics from food packaging, water bottles, and other sources, this study suggests these particles might be interfering with our reproductive health too. This research helps explain why fertility rates have been declining and highlights the need to reduce plastic pollution in our environment.
Microplastics and nanoplastics in follicular fluid are associated with diminished ovarian reserve: clinical and molecular insights
Researchers found that microplastics and nanoplastics present in follicular fluid are associated with diminished ovarian reserve in women. The study provides evidence suggesting that exposure to these particles may harm female ovarian function. The findings point to the environment-gut-ovarian axis as a potential pathway through which micro- and nanoplastic exposure could contribute to reproductive health concerns.
Microplastics are present in women’s and cows’ follicular fluid and polystyrene microplastics compromise bovine oocyte function in vitro
Researchers detected microplastics in follicular fluid from both women and cows and showed that polystyrene microplastics disrupt oocyte development, providing the first evidence that microplastics can penetrate reproductive barriers and potentially contribute to the global decline in fertility.
Microplastics are present in women’s and cows’ follicular fluid and polystyrene microplastics compromise bovine oocyte function in vitro
Researchers detected microplastics in the follicular fluid of both women and cows, marking one of the first studies to find these particles in reproductive tissues. In laboratory tests, polystyrene microplastics impaired bovine egg cell function at concentrations comparable to what was found in the follicular fluid. The findings raise questions about whether microplastic exposure could be a contributing factor in the widespread declines in reproductive health observed in recent decades.
Micro- and nanoplastic (MNPs) exposure at single-cell resolution impaired placental function and cellular dynamics
Researchers performed single-cell transcriptomic analysis of placentas from pregnant women exposed to micro- and nanoplastics, finding that MNP exposure altered trophoblast, macrophage, and fibroblast subpopulations, suggesting impaired placental function through disruption of cell communication and immune regulation.
Integrative Proteomics and Transcriptomics Profiles of the Oviduct Reveal the Prolificacy-Related Candidate Biomarkers of Goats (Capra hircus) in Estrous Periods
Integrative proteomics and transcriptomics of goat oviducts during estrous periods identified molecular networks regulating gamete storage, fertilization, and early embryonic development in high-prolificacy animals. The findings advance understanding of fecundity regulation at the molecular level in livestock reproductive biology.
Beyond apoptosis: evidence of other regulated cell death pathways in the ovary throughout development and life
This review explores different types of programmed cell death in the ovary beyond the well-known process of apoptosis, and their roles in ovarian development and function throughout a woman's life. While not focused on microplastics directly, these cell death pathways are important because emerging research shows that microplastic and nanoplastic exposure can trigger abnormal cell death in ovarian tissue. Understanding these pathways is key to assessing how environmental pollutants may affect female fertility.
Exposição De Microplásticos E Nanoplásticos Ao Tecido Ovariano: Uma Revisão Integrativa
This integrative review examines the impact of micro- and nanoplastics on female ovarian tissue, synthesizing animal model studies showing damage to follicular structures, increased oxidative stress, and disrupted reproductive hormone signaling.
High Prolactin Concentration Induces Ovarian Granulosa Cell Oxidative Stress, Leading to Apoptosis Mediated by L-PRLR and S-PRLR
This paper is not relevant to microplastics research — it investigates how high prolactin concentrations induce oxidative stress and apoptosis in ovine ovarian granulosa cells, a reproductive endocrinology study.
Size- and hydrophobicity-dependent accumulation of microplastics in follicular fluid is linked to impaired ovarian reserve in women undergoing medically assisted reproduction
Researchers measured microplastic concentrations in follicular fluid and blood from women undergoing fertility treatment and found that nearly all samples contained microplastics. Higher microplastic concentrations in follicular fluid were significantly associated with reduced oocyte yield and lower odds of pregnancy, with evidence suggesting that certain hydrophobic polymers selectively accumulate in the ovary.
Characterization of microplastics in human follicular fluid and assessment of their potential impact on mouse oocyte maturation in vitro
Scientists found microplastics in human follicular fluid, the liquid surrounding eggs in the ovaries, after analyzing samples from 19 women. When they tested how these particles affect egg development in mice, they found that certain types of microplastics reduced the ability of eggs to mature properly, raising concerns about potential effects on fertility.
Single‐Cell Transcriptomic Analysis Reveals Hair Cell‐Specific Molecular Responses to Polystyrene Nanoplastics in a Zebrafish Embryo Model
Researchers exposed zebrafish embryos to polystyrene nanoplastics at environmentally relevant concentrations and used single-cell RNA sequencing to identify hair cell-specific transcriptional changes in the inner ear, finding molecular-level effects without overt developmental phenotypes.
Exposição De Microplásticos E Nanoplásticos Ao Tecido Ovariano: Uma Revisão Integrativa
This integrative review (in Portuguese) examines published evidence on the effects of micro- and nanoplastic exposure on female ovarian tissue morphology, finding disrupted folliculogenesis, oxidative stress, and hormonal interference reported across animal model studies.
Molecular dominance investigation for large-sized parents of Chinese Mitten Crab ( Eriocheir sinensis ) based on ovarian transcriptome
This transcriptomics study compared ovarian gene expression in large and small Chinese mitten crabs to understand why offspring from larger parents perform better. It is a crab aquaculture genetics study not related to microplastics or human health.
Food nutrition and toxicology targeting on specific organs in the era ofsingle-cell sequencing
This review examines how single-cell sequencing technologies can reveal organ-specific effects of food nutrients and toxicants, including contaminants like microplastics, by uncovering cellular heterogeneity and tissue-biased responses that traditional methods miss.