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Single-cell sequencing reveals the reproductive variations between primiparous and multiparous Hu ewes

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology 2023 13 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 50 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Ting Ge, Ting Ge, Ting Ge, Ting Ge, Ting Ge, Ting Ge, Yifan Wen, Yifan Wen, Yifan Wen, Yifan Wen, Yifan Wen, Yifan Wen, Bo Li, Ting Ge, Bo Li, Xiaoyu Huang, Xiaoyu Huang, Xiaoyu Huang, Xiaoyu Huang, Shaohua Jiang, Shaohua Jiang, Shaohua Jiang, Enping Zhang Enping Zhang

Summary

Researchers used single-cell sequencing to compare reproductive differences between first-time and experienced mother Hu ewes. The study identified key differences in gene expression within granulosa cells, suggesting these cells play a critical role in determining reproductive capacity. Several specific genes were highlighted as important regulators of follicular development and overall fecundity in sheep.

Body Systems

Reproductive

This study provides insights into the molecular mechanisms underlying the high fecundity of Hu sheep. The differences in gene expression profiles, particularly in the granulosa cells, suggest that these cells play a critical role in female prolificacy. The findings also highlight the importance of genes such as JPH1, LOC101112291, FTH1, and FTL in regulating granulosa cell function and follicular development.

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