Papers

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Article Tier 2

Detection and Analysis of Microplastics in Human Sputum

Researchers analyzed sputum (mucus from the lungs) from 22 patients with respiratory diseases and found microplastics in every single sample, identifying 21 different plastic types. Polyurethane was the most common type detected, and most particles were smaller than 500 micrometers. This study provides direct evidence that humans are inhaling microplastics, with factors like smoking and medical procedures increasing the amount found in the respiratory tract.

2022 Environmental Science & Technology 494 citations
Article Tier 2

Deposition of microplastics associated with bioaccumulation of heavy metals in human lungs of smokers: Implications of adsorption and mobilization of metals via microplastics

Researchers compared lung tissue from smokers and non-smokers and found that smokers accumulated more microplastics alongside elevated levels of heavy metals in lung tissue, suggesting that tobacco smoke enhances chelation of heavy metals to airborne microplastics, increasing lung bioaccumulation.

2025
Article Tier 2

Microplastics contamination in branded cigarettes: Characterization and potential burning inhalation risk assessment

Analysis of 21 domestic and international cigarette brands found microplastics present in filter materials, raising concern about inhalation exposure during smoking as an underrecognized route of human microplastic intake.

2024 1 citations
Article Tier 2

Presence of microplastics in human’s respiratory system: bronchoalveolar and bronchial lavage fluid

Researchers analyzed bronchial and bronchoalveolar lavage fluid from patients undergoing bronchoscopy and confirmed the presence of microplastics in the human respiratory system. They characterized the types, sizes, and quantities of microplastic particles found at different levels of the airways. The study provides direct evidence that microplastics deposit within human lungs and suggests that respiratory exposure is a meaningful route of human microplastic intake.

2025 Journal of Environmental Health Science and Engineering 1 citations
Article Tier 2

Detection of Microplastics in Human Bronchoalveolar Lavage Fluid: Preliminary Evidence of Respiratory Exposure to Environmental Contaminants

Researchers analyzed bronchoalveolar lavage fluid from eight adult patients undergoing diagnostic bronchoscopy and detected microplastics in the samples using microscopy, providing preliminary direct evidence that airborne microplastics deposit in the human respiratory tract.

2025 Cureus
Article Tier 2

Isolation and characterization of microplastics from the human respiratory system: Sputum, broncho-alveolar lavage fluid, and pleural fluid simultaneously

In the first study of its kind in Iran, researchers found microplastics in every sample collected from the human respiratory system, including sputum, lung fluid, and the fluid surrounding the lungs. Polyester fibers were the most common type detected, and people with occupational exposure or smoking habits had higher amounts, confirming that we regularly breathe in microplastics that reach deep into our lungs.

2024 Environmental Pollution 29 citations
Article Tier 2

Impact of Airborne Microplastics on Induced Sputum of Urban Dwellers: the Role of Environmental and Occupational Factors

Researchers analyzed induced sputum samples from 25 patients with respiratory diseases and found microplastics present in all samples, with concentrations ranging from 6 to 500 particles per 100 mL. Active smokers and workers in occupations with high plastic exposure had significantly higher microplastic concentrations. The study suggests that airborne microplastic inhalation is widespread among urban residents and may be influenced by both lifestyle and occupational factors.

2024 WIT transactions on ecology and the environment 3 citations
Article Tier 2

Microplastics inhalation: evidence in human lung tissue

Microplastic particles were found in human lung tissue samples collected during surgery, confirming that people inhale and retain microplastics in pulmonary tissue, with polypropylene and polyethylene terephthalate among the polymers identified, raising concerns about chronic respiratory and inflammatory effects.

2021 10 citations
Article Tier 2

Evidence of Microplastics in Bronchoalveolar Lavage Fluid among Never-Smokers: A Prospective Case Series

Researchers conducted a prospective case series examining bronchoalveolar lavage fluid from 18 never-smokers in China using laser direct infrared spectroscopy and scanning electron microscopy. The study found evidence of microplastic deposition in the respiratory tract, suggesting that inhaled microplastics can accumulate in the lungs even among people who have never smoked.

2023 Environmental Science & Technology 76 citations
Article Tier 2

First evidence of microplastics isolated in European citizens’ lower airway

Researchers provided the first evidence of microplastics in the lower airways of living European adults, using bronchoalveolar lavage fluid from 44 patients. Nearly all detected particles were microfibers averaging about 1.7 millimeters in length, with an average concentration of roughly 9 items per 100 milliliters of fluid. The findings confirm that microplastics reach deep into the human respiratory system, though the health implications require further investigation.

2022 Journal of Hazardous Materials 198 citations
Review Tier 2

The Hidden Threat of Microplastics in Traditional Cigarettes: A Narrative Review of Health and Environmental Risks

This review reveals that microplastics have been detected in 99% of cigarette filters, meaning smokers are inhaling and ingesting these particles with every cigarette. Microplastics have been found in the blood, lungs, placenta, and feces of the general population, but smokers face particularly high exposure. The improper disposal of cigarette butts also releases microplastics into the environment, making cigarettes a significant and overlooked source of microplastic pollution.

2025 Journal of Clinical Medicine 6 citations
Article Tier 2

Presence of airborne microplastics in human lung tissue

Researchers examined human lung tissue from autopsies and found microplastic particles and fibers in 13 out of 20 samples. The most common plastics were polyethylene and polypropylene, with particles smaller than 5.5 micrometers. This study provides direct evidence that inhaled microplastics accumulate in human lungs, raising concerns about potential long-term effects on respiratory health.

2021 Journal of Hazardous Materials 1155 citations
Article Tier 2

Effects of microplastics from cigarette filters on two aquatic species and in vitro human lung cells

Researchers examined the effects of microplastics from cigarette filters on two aquatic species and conducted in vitro cell tests to assess human health risks. Cigarette filter microplastics caused toxicity in both aquatic organisms and human cells, underscoring the environmental and health hazards of this overlooked microplastic source.

2024 Zenodo (CERN European Organization for Nuclear Research)
Systematic Review Tier 1

The Effect of Nanoplastics and Microplastics on Lung Morphology and Physiology: a Systematic Review

This systematic review examines how inhaled microplastics and nanoplastics affect lung structure and function. The research found that indoor microplastic concentrations are often higher than outdoor levels due to household materials shedding fibers, and that inhaled particles can accumulate in different parts of the lungs. These findings suggest that breathing in plastic particles at home and work could contribute to respiratory health problems over time.

2024 The Medical and Ecological Problems 1 citations
Article Tier 2

Microplastics from cigarette filters: Comparative effects on selected terrestrial and aquatic invertebrates

Researchers compared the effects of microplastics from smoked and unsmoked cigarette filters on both land and water invertebrates. Smoked filter microplastics were more toxic due to the added chemicals from tobacco smoke, causing reduced survival and reproduction in the test organisms. Since cigarette butts are one of the most littered items worldwide, this study shows they are a significant and underappreciated source of toxic microplastic pollution in the environment.

2025 Environmental Pollution 7 citations
Article Tier 2

Human Exposure to Airborne Microplastics: A Study on Detection and Potential Health Effects Using BAL Fluid

This study detected inhaled microplastics in bronchoalveolar lavage fluid from the lower respiratory tract of human patients and found associations between microplastic presence and markers of lung inflammation and impaired lung function.

2025 Journal of Pharmacy And Bioallied Sciences
Article Tier 2

Microplastics in urine, sputum and lung lavage fluid from patients with respiratory illnesses

Researchers analyzed urine, sputum (mucus from coughing), and lung fluid from 30 patients with respiratory conditions in Iran and found microplastics in all three types of samples. Sputum contained the most particles (358 total), dominated by polyurethane fibers, while urine had the fewest (9 particles). The different types and sizes of plastics found in each fluid suggest the body sorts and distributes inhaled and ingested microplastics through different pathways.

2025 Environmental Research 30 citations
Clinical Trial Tier 1

New evidence of the presence of micro- and nanoplastic particles in bronchioalveolar lavage samples of clinical trial subjects

Researchers found micro- and nanoplastic particles in the lung fluid of patients undergoing bronchoscopy — a procedure that samples the deep airways — marking the first detection of airborne nanoplastics in the lower respiratory tract of living humans. All samples contained plastic particles, confirming that people in Northern Europe are regularly inhaling plastics, though the health effects remain under investigation.

2023 Heliyon 24 citations
Article Tier 2

Respiratory Toxicity of Microplastics: Mechanisms, Clinical Outcomes, and Future Threats

This review summarized the respiratory toxicity of airborne microplastics, covering their sources, the routes by which they penetrate deep into lung tissue, and the range of clinical outcomes from chronic inflammation to potential malignancy. The authors warn that inhalation exposure represents an underappreciated and growing public health threat.

2025 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Bronchoalveolar Lavage as a Diagnostic Window into Human Exposure to Microplastics and Associated Lung Changes

Bronchoalveolar lavage analysis revealed microplastics in the lower respiratory tract of human patients and showed associated inflammatory changes, providing direct evidence of pulmonary microplastic exposure and supporting the need for occupational and environmental health monitoring.

2025 Journal of Pharmacy And Bioallied Sciences
Article Tier 2

Microplastics exposed by respiratory tract and exacerbation of community-acquired pneumonia: The potential influences of respiratory microbiota and inflammatory factors

Researchers found that microplastics were present in the lungs of pneumonia patients, and that patients with severe pneumonia had higher levels of microplastics in their airways than those with milder cases. The microplastics appeared to worsen lung infections by disrupting the balance of airway bacteria and increasing inflammation. This study provides early evidence that inhaled microplastics may make respiratory infections more dangerous in humans.

2025 Environment International 8 citations
Article Tier 2

Detection of microplastics in human nasal mucosa

Microplastic particles were detected for the first time in human nasal mucosa samples, with polymer types and concentrations quantified, providing direct evidence that the upper respiratory tract is a site of microplastic deposition from inhaled air.

2024 Laryngo-Rhino-Otologie
Article Tier 2

Cigarette butts as a microfiber source with a microplastic level of concern

Researchers investigated whether cigarette butts are a significant source of microfiber pollution by analyzing smoked and unsmoked filters. They found that cigarette filters release large quantities of cellulose acetate microfibers, with smoked filters releasing even more than unsmoked ones due to degradation during use. The study identifies discarded cigarette butts as an overlooked but substantial contributor to microplastic pollution in the environment.

2020 The Science of The Total Environment 201 citations
Article Tier 2

Detection of microplastics in human lung tissue using μFTIR spectroscopy

Researchers analyzed lung tissue from 13 people and found microplastics in 11 of the samples, identifying 12 different plastic types including polypropylene and polyester. The particles were found in all regions of the lungs, with significantly higher concentrations in the lower lung. This is one of the first studies to directly confirm that microplastics from everyday environments can be inhaled and accumulate deep in human lung tissue.

2022 The Science of The Total Environment 1264 citations