0
Clinical Trial ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 1 ? Systematic review or meta-analysis. Synthesizes findings across many studies. Strongest evidence. Human Health Effects Nanoplastics Sign in to save

New evidence of the presence of micro- and nanoplastic particles in bronchioalveolar lavage samples of clinical trial subjects

Heliyon 2023 24 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Ieva Uogintė, Agnė Vailionytė, Martynas Skapas, Dave Bolanos, Ernesta Bagurskienė, Vygantas Gruslys, Rūta Aldonytė, Rūta Aldonytė, Steigvilë Byčenkienė

Summary

Researchers found micro- and nanoplastic particles in the lung fluid of patients undergoing bronchoscopy — a procedure that samples the deep airways — marking the first detection of airborne nanoplastics in the lower respiratory tract of living humans. All samples contained plastic particles, confirming that people in Northern Europe are regularly inhaling plastics, though the health effects remain under investigation.

Body Systems
Models
Study Type Human

This is the first study reporting the presence of airborne nano-sized plastic particles in the bronchoalveolar lavage fluid (BALF) samples of patients undergoing diagnostic bronchoscopy. The results represent the plastic pollution content in the lower airways of the residents of Northern Europe. Airborne micro- and nanoplastic particles (MP/NPs) are widely dispersed worldwide and intrude on human organisms to various extents, with the respiratory tract being the first line of exposure. The amounts of inhaled MP/NPs, their fate in the human respiratory tract, and the effects on the health of human airways and other exposed organs remain largely unknown. In this clinical study, human BALF samples were assessed by means of optical and transmission electron microscopy coupled with energy-dispersive X-ray spectroscopy (TEM-EDX). Results show that MP/NPs levels vary in the interval of 0.14-12.8 particles per 100 ml of BALF and are present in all samples tested, mainly in a fragmented form. External pollution by MP/NPs was excluded by carefully choosing methodology and equipment. This finding is a timely addition of valuable information and stimulates further research into the biological effects of inhaled MP/NPs.

Share this paper